Navigation Links
Scripps research scientists discover chemical triggers for aggression in mice
Date:12/6/2007

anding the aggression pathway as a general model for brain response.

As a first step in the current study, the group sought to identify specific chemical triggers for aggression in mice, which other researchers had shown involved urine. The Stowers group separated out several classes of chemicals within the urine, then individually swabbed each class onto the backs of castrated mice to determine which could spark an aggressive response by another male. Castrated males lose the ability to elicit aggression on their own, so any such response could be attributed to the added chemicals.

Using this experimental setup, the researchers were able to show specific compounds triggered aggression. Upon examination, the scientists found that these compounds fell into two distinct chemical groups-low molecular weight and high molecular weight proteins.

Particularly intriguing were the high molecular weight compounds, as few high molecular weight compounds exist in urine and none had ever before been shown to act as pheromones. The Stowers group focused on these for the remainder of the study.

Tracing Phermones Path

Next, the Stowers lab sought to discover the effect of these high molecular weight compounds on two neurological organs that could potentially convey the pheromone signals to the brain. The first, called the vomeronasal organ (VNO), is located above the roof of the mouth in the nasal cavity. The second is the main olfactory epithelium (MOE), found under the eyeball at the top back portion of the nasal cavity.

Which of these two organs is the main starting point for the aggression pathway is somewhat controversial. Stowers' group had shown in past work that mice genetically altered to lack the VNO did not have aggression responses, suggesting this organ plays a key role, but other researchers had made similar findings with knockout mice lacking the MOE.

To further explore this aspect of signal pro
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scripps Research scientists shed new light on how antibodies fight HIV
2. Scripps Health Treats More Than 160 Fire Victims at Emergency Departments Across San Diego County
3. Stanford researchers find culprit in aging muscles that heal poorly
4. Children of depressed moms do better when dad is involved, SLU researcher finds
5. UCLA researchers identify markers that may predict diabetes in still-healthy people
6. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
7. New research shows how chronic stress worsens neurodegenerative disease course
8. New research explores newborn in-hospital weight loss
9. Research may unlock mystery of autisms origin in the brain
10. Bipolar disorder relapses halved by Melbourne researchers
11. HIVs impact in Zimbabwe explored in new research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/6/2015)... 06, 2015 At Natural Products ... today the launch of its powerful, location-aware iOS ... and sustainable products at any retailer that carries ... at Expo West Booth 6054. , Makeena’s ... Kosher, non-GMO, organic, Paleo, and vegan, among many ...
(Date:3/6/2015)... Since Medicare began paying for chronic care ... an overwhelming demand from providers for straightforward guidance on ... The Centers for Medicare & Medicaid Services (CMS) ... updated white paper—“ Providing and Billing Medicare for Chronic ... yet practical “how to” manual for providers looking to ...
(Date:3/6/2015)... 06, 2015 Jvion, the Atlanta-based ... of a Clostridium Difficile (C Diff) predictive use ... Diff use case is the latest in a ... acquired infections, chronic conditions, and individual illnesses. Using ... Diff solution flags at risk individuals to help ...
(Date:3/6/2015)... Utilizing the latest in nutritional science to help ... has enabled Diet Doc to add powerful new ... of fat loss enhancement medications. And now, they are ... to help people throughout the country begin losing dangerous ... appealing to new clients because they can receive Appetite ...
(Date:3/6/2015)... March 06, 2015 The Gluten-Free ... Celiac Association, is pleased to announce that Dufflet ... Rosenberg, has expanded their product line of gluten-free ... as scrumptious and as satisfying as any of ... scratch, and never contains hydrogenated fats or oils, ...
Breaking Medicine News(10 mins):Health News:Makeena Launches App that Makes Healthy and Sustainable Products More Affordable for Shoppers 2Health News:Makeena Launches App that Makes Healthy and Sustainable Products More Affordable for Shoppers 3Health News:Updated PYA White Paper Meets Demand for Guidance on Providing and Billing Medicare for Chronic Care Management 2Health News:Jvion Predicts Patients at Risk of C Difficile Infection to Reduce Risk and Save Lives 2Health News:Diet Doc Announces Never Before Offered Discounts, Promotions and Savings for New and Existing Clients 2Health News:Diet Doc Announces Never Before Offered Discounts, Promotions and Savings for New and Existing Clients 3Health News:Diet Doc Announces Never Before Offered Discounts, Promotions and Savings for New and Existing Clients 4Health News:Dufflet Pastries® Impressive Collection of Brownies, Cakes, Pies and Cakelets® Now Includes a Gluten-Free Line Certified By the GFCP. 2Health News:Dufflet Pastries® Impressive Collection of Brownies, Cakes, Pies and Cakelets® Now Includes a Gluten-Free Line Certified By the GFCP. 3Health News:Dufflet Pastries® Impressive Collection of Brownies, Cakes, Pies and Cakelets® Now Includes a Gluten-Free Line Certified By the GFCP. 4
... RESEDA, Calif., June 16 The famed nonprofit Los ... prevention and,fitness program designed to address one of the ... by the Jewish Community Foundation,the largest manager of charitable ... new fall prevention and fitness program becomes part of ...
... RELEASE, 16 June 2008] A unique new study from the ... of families and the public have little impact on if ... or the opposite sex. Instead, hereditary factors and the individual,s ... sexual partners. , The study is the largest in the ...
... recognize partners, innovative use of Microsoft technology to ... customer expectations and solve business ... partners,that delivered exemplary solutions to customers, Microsoft Corp. ... Microsoft Partner of the,Year Awards. The awards honor ...
... 16 BME (BioMedical Enterprises,Inc.), a privately held ... implant technology, today announced the launch of the ... fixation of,bone., The BOSS is an orthopaedic ... adhesion. Like the BME OSStaple(TM) product line, the ...
... Comprehensive Cancer Center, has been appointed by President Bush to the ... appointees named to the board on June 12, 2008. , The ... National Cancer Institute (NCI). The role of the board is ... Services and the director of the NCI on issues that ...
... provider based at The University of Queensland, and Q-Pharm, ... have formed a strategic alliance. , The alliance ... clients in the biotechnology and pharmaceutical industries. , ... the two businesses, which are both commercialisation enterprises of ...
Cached Medicine News:Health News:Los Angeles Jewish Home Institutes New Fall Prevention Program With Jewish Community Foundation Grant 2Health News:Los Angeles Jewish Home Institutes New Fall Prevention Program With Jewish Community Foundation Grant 3Health News:Microsoft Announces 2008 Partner of the Year Awards Finalists and Winners 2Health News:Microsoft Announces 2008 Partner of the Year Awards Finalists and Winners 3Health News:Microsoft Announces 2008 Partner of the Year Awards Finalists and Winners 4Health News:Microsoft Announces 2008 Partner of the Year Awards Finalists and Winners 5Health News:Microsoft Announces 2008 Partner of the Year Awards Finalists and Winners 6Health News:Microsoft Announces 2008 Partner of the Year Awards Finalists and Winners 7Health News:BME (BioMedical Enterprises, Inc.) Announces U.S. Launch of the Barbed OSStaple(TM) (BOSS) Nitinol Implant 2Health News:TetraQ and Q-Pharm form strategic alliance 2Health News:TetraQ and Q-Pharm form strategic alliance 3
(Date:3/5/2015)... SHANGHAI, March 5, 2015 WuXi PharmaTech (Cayman) ... R&D capability and technology platform company serving the pharmaceutical, ... and the United States, today announced its financial results ... Fourth-Quarter 2014 Highlights , Net Revenues ... , Laboratory Services Net Revenues Grew 17.7% Year Over ...
(Date:3/5/2015)... Germany , March 5, 2015 ... and CureVac today announced that the foundation has ... million) in CureVac, a leading clinical-stage biopharmaceutical company ... the agreement, the foundation will also provide separate ... based on CureVac,s proprietary messenger RNA (mRNA) platform. ...
(Date:3/5/2015)... , March 5, 2015 CANTEL MEDICAL CORP. (NYSE: ... second quarter ended January 31, 2015 on Thursday, March 12 ... discuss the results at 11:00 AM ET. ... 5 to 10 minutes before the beginning of the call. ... the call will be available from Thursday, March 12, 2015 ...
Breaking Medicine Technology:WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 2WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 3WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 4WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 5WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 6WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 7WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 8WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 9WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 10WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 11WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 12WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 13WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 14WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 15WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 16WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 17WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 18WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 19WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 20WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 21WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 22The Bill & Melinda Gates Foundation and CureVac Collaborate to Accelerate the Development of Transformative Vaccine Technology 2The Bill & Melinda Gates Foundation and CureVac Collaborate to Accelerate the Development of Transformative Vaccine Technology 3The Bill & Melinda Gates Foundation and CureVac Collaborate to Accelerate the Development of Transformative Vaccine Technology 4Cantel Medical Corp. To Hold Conference Call To Discuss Results For Its Second Quarter Ended January 31, 2015 2
Trilogy Pacemakers incorporates the clinically proven Omniscence™ accelerometer sensor with it's automatic alogorithms. The Trilogy family of pacemakers feature an array of products for bradyar...
... The Identity pacemaker family, which ... pacemaker, provides clinicians with the ... including the revolutionary AF Suppression™ ... U.S. commercially approved algorithm designed ...
Innovative new tools for more efficient patient management begin when the pacemaker is implanted. These sophisticated tools are in effect each day, and they help automate follow-up tasks....
The INSIGNIA® pacing systems allow the physician to provide customized adaptive-rate pacing therapy to meet individual patient needs....
Medicine Products: