Navigation Links
Scripps Translational Science Institute joins Jackson Laboratory tumor consortium
Date:6/28/2011

The Scripps Translational Science Institute (STSI) of San Diego, Calif., has joined a national consortium of research institutions headed by The Jackson Laboratory (JAX) that is building a library of primary human tumors with the goal of developing highly targeted cancer therapies.

In its role as a consortium member, STSI will provide solid human tumor samples to JAX, which will graft them into mouse models for scientific study. STSI scientists will then have access to the models to conduct research on how to better understand and treat cancer, including the potential for tumor-specific therapies.

JAX will perform the initial genomic characterization of the tumors and will share this data with all participating institutions. STSI is a major research collaboration involving the nonprofit Scripps Health system and The Scripps Research Institute, both of San Diego.

JAX launched the Primary Human Tumor Consortium in 2009. Other participating institutions outside San Diego include the University of Florida, the Swedish Neuroscience Institute in Seattle and UC Davis Cancer Center.

Mouse models that can accept newly resected human tumors offer a highly productive way to develop and test cancer treatments. Mouse models of virtually any kind of cancer can be developed, providing a more individualized approach to finding new treatments.

This approach stands in stark contrast to the standard way of discovering new therapies for cancer, which relies on the use of tumor cell lines. The tumor cell-line approach can be problematic, since genetic mutations naturally occur as those cells divide and reproduce. Consequently, the cells may drift into a different genetic profile and any treatments designed to target the original tumor won't work. Also, the cell-line approach provides insights into which therapies are ineffective, but doesn't predictably prove which ones are effective.

"By joining this consortium, Scripps will contribute to and share in a tumor library that will vastly exceed what any institution could build on its own," said Nicholas J. Schork, Ph.D., director of bioinformatics and biostatistics at STSI. "This shared resource ultimately will greatly expand research capacity for all consortium members, with the goal of accelerating drug development for individualized approaches to each type of tumor."

Located at The Jackson Laboratory's JAX--West facility in Sacramento, Calif., the Primary Human Tumor Consortium seeks additional health care and research partners to speed the development of this tumor library resource. To date, the consortium has engrafted 172 tumors, with tumor sites including prostate, pancreas, lung, kidney, colon, breast, brain and bladder.

"The biomedical research community needs a common, readily accessible resource to support this vital effort," said JAX Executive Vice President and Chief Operating Officer Chuck Hewett, Ph.D. "No single cancer center has a sufficiently broad patient population to meet this need, so we must work together."


'/>"/>

Contact: Joyce Peterson
joyce.peterson@jax.org
207-288-6058
Jackson Laboratory
Source:Eurekalert

Related medicine news :

1. Scripps Health Begins Pioneering Study of Human Tumor Sequencing in Cancer Patients
2. Top Scientists Explore the Origin of Life in Annual Lasker Lecture at Scripps Research Institute Florida Campus
3. Scripps Blood & Marrow Transplant Program Celebrates 30th Anniversary of Providing Life-Saving Care
4. Scripps Memorial Hospital La Jolla First in San Diego to Achieve Magnet Nursing Re-designation
5. Scripps Announces Plans for Region's First Proton Therapy Center; $185 Million Facility to Offer Advanced Care to Cancer Patients
6. Scripps Research scientists share $2 million in Florida state research grants
7. Scripps Center for Executive Health Now Offers Genetic Testing
8. Scripps Research scientists uncover previously unknown natural mechanism that controls cocaine use
9. NIH awards Scripps Florida scientists $2.3 Million to develop drug addiction treatments
10. Scripps Research scientists solve long-standing mystery of protein quality control mechanism
11. Scripps and Trius team up to develop new antibiotics with US Department of Defense grant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, ... ... School of Pharmacy (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, ... professionals on guideline updates for the primary prevention of cardiovascular diseases during ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term ... long-term care insurance companies have a waiver for care if the client has a ... when the family pays for care, is often waived, so the benefits from their ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids ... Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, ... run is geared towards children of all ages; it is a non-competitive, non-timed event, ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a ... has been awarded a contract by the Center for Medicare and Medicaid Services ... accelerate the enterprise use of Agile methodologies in a consistent and high value ...
(Date:10/12/2017)... ... 12, 2017 , ... First Healthcare Compliance (FHC), an industry ... a range of technology and learning solutions at the 68th Annual American Healthcare ... be held October 14–18, 2017 at the Mandalay Bay Resort in Las Vegas, ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... 2017 AVACEN Medical (AVACEN) announced that its ... helping those with the widespread pain associated with fibromyalgia ... in Essex, England commented, "I ... experiencing no sleep at all, tremendous pain, with every ... recommend [the AVACEN 100] enough, how this has and ...
(Date:9/19/2017)... LOUISVILLE, Ky. , Sept. 19, 2017   ZirMed ... and predictive analytics, today announced that it has been ranked ... the Black Book™ Rankings 2017 User Survey. ZirMed ... software solution for large hospitals and medical centers over 200 ... in Black Book,s healthcare technology user survey history. ...
(Date:9/18/2017)... , Sept. 18, 2017 ... fields of bioinformatics and immune engineering, today ... protective avian influenza A (H7N9) vaccine. ... related to seasonal influenza and presents a ... on prior exposure to be effective. Using ...
Breaking Medicine Technology: