Navigation Links
Scripps Research scientists solve long-standing mystery of protein 'quality control' mechanism
Date:9/12/2010

ps assembling the protein, and recruits factors that promote the protein's release into the cellular cytoplasm so the protein can go forth and perform its biological functions. When mRNA is accidentally missing a stop codon, however, the ribosome is like an auto manufacturing plant that can't get a car off the end of the linethe line stalls and production stops.

"In addition, these defective mRNA are problematic because they are translated into aberrant proteins," explained Joazeiro. "For these reasons, there are machineries in all living organismswhether bacteria or more complex eukaryotic organismsthat target and destroy both these non-stop messenger RNA and the resulting non-stop proteins."

For some 15 years, scientists have understood the mechanism that identifies and destroys these problematic non-stop proteins in bacteria. In these organisms, non-stop proteins are tagged by a marker known as tmRNA or ssrA, which then leads to their destruction.

In more complex eukaryotic organisms, which range from yeast to humans, though, the mechanism for identifying and eliminating such dangerous non-stop errors has remained a mysteryuntil now.

A Fresh Approach

Previously, scientists had failed to discover the missing quality control mechanism using a "homology" approach, in which they searched for molecules from eukaryotic organisms that looked like the bacterial tmRNA. Joazeiro and a postdoctoral fellow in his lab Mario Bengtson got to the mechanism by a different path.

In collaboration with Steve Kay's lab (now at the University of California, San Diego) the Joazeiro lab had discovered that a strain of mice carrying a mutation in a molecule known as Listerin experienced neurodegeneration. Because of recent studies from other labs and their own, the scientists suspected that Listerin could have a role in non-stop protein degradation.

To investigate, in the current study Joazeiro and Bengtson used the
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scripps Health Begins Pioneering Study of Human Tumor Sequencing in Cancer Patients
2. Top Scientists Explore the Origin of Life in Annual Lasker Lecture at Scripps Research Institute Florida Campus
3. Scripps Blood & Marrow Transplant Program Celebrates 30th Anniversary of Providing Life-Saving Care
4. Scripps Memorial Hospital La Jolla First in San Diego to Achieve Magnet Nursing Re-designation
5. Scripps Announces Plans for Region's First Proton Therapy Center; $185 Million Facility to Offer Advanced Care to Cancer Patients
6. Scripps Research scientists share $2 million in Florida state research grants
7. Scripps Center for Executive Health Now Offers Genetic Testing
8. Scripps Research scientists uncover previously unknown natural mechanism that controls cocaine use
9. NIH awards Scripps Florida scientists $2.3 Million to develop drug addiction treatments
10. Embedded Mobile & M2M Device revenues to Rise to Almost $19 Billion Globally by 2014, Says Juniper Research
11. 2010 HSR Impact Award recognizes surgical safety research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2015)... , ... August 30, 2015 , ... ... joined the company as the new Global Communications Director for InHealth Media. ... experience having spent the last 16 years doing on-air television, producing shows, on ...
(Date:8/30/2015)... Boca Raton, Fl (PRWEB) , ... August 30, ... ... today that Kathleen Kall has been promoted from Administrative assistant to Executive Assistant ... communication, you’ll interact with a proven professional, focused on your goals. Kathleen ...
(Date:8/29/2015)... VA (PRWEB) , ... August 30, 2015 , ... ... Webinar**, Sept. 15, 2015 — 1:30 p.m. – 3:00 p.m. EDT, http://www.fdanews.com/electronicinformedconsent ... more than a simple digital handwritten signature. , Clinical trial sites ...
(Date:8/29/2015)... (PRWEB) , ... August 29, 2015 , ... ... mesothelioma develops, may extend and improve the lives of patients, according to a ... Click here to read the full article. , The authors of ...
(Date:8/29/2015)... ... August 29, 2015 , ... ProDrop Particles includes over 40 particle backdrops designed ... of unique footage that users can shrink and stretch in the Final Cut Pro ... can customize color, brightness, scale, speed, range, and flare attributes with intuitive controls found ...
Breaking Medicine News(10 mins):Health News:InHealth Media Appoints New Global Communications Director 2Health News:NPI Appoints New Executive Assistant To CEO 2Health News:FDAnews Announces — Electronic Informed Consent for Clinical Trials: Best Practices Webinar, Sept. 15, 2015 2Health News:FDAnews Announces — Electronic Informed Consent for Clinical Trials: Best Practices Webinar, Sept. 15, 2015 3Health News:FDAnews Announces — Electronic Informed Consent for Clinical Trials: Best Practices Webinar, Sept. 15, 2015 4Health News:Top Mesothelioma Researchers Highlight Targeted Therapies in New Report, According to Surviving Mesothelioma 2Health News:FCPX Effects Developer, Pixel Film Studios, Releases ProDrop Particles. 2
... Researchers at the University of Pittsburgh School of Medicine ... Institutes of Health, may be hot on the heels of ... way to not only protect healthy tissue from the toxic ... findings appear today in Science Translational Medicine . ...
... offspring thrive, study shows , WEDNESDAY, Oct. 21 (HealthDay News) ... reproduction via sex with a partner beats going it alone, evolutionarily ... do it one of two ways -- with a friend or ... the odds that the worms, children will live longer. , ...
... Speed Veterans, Appeals , WASHINGTON Oct. 21 ... of four new Veterans Law Judges to the Board of ... the number of cases being decided. , "Veterans have earned ... claims for benefits," Secretary Shinseki said. "This expansion of BVA ...
... a virtual subculture of "johns" who share information electronically ... to a new study co-authored by a Michigan State ... and Kristie Blevins of the University of North Carolina ... act alone and do not interact for fear of ...
... Van,s Gifts ... , ... -- For all those times when the words ,thank you, don,t live up to ... right message, at the right time and for the right price. , ,Van,s Gifts, Inc., a ...
... ... Washington, DC ... of the world,s vaccines and immunization launched by the World Bank, the United Nations Children,s ... Foundation strives to achieve. As a proud partner of the Measles Initiative and ...
Cached Medicine News:Health News:Pitt/NIH team find way to protect healthy cells from radiation damage 2Health News:Sex With a Partner Makes Evolutionary Sense: Study 2Health News:Secretary Announces Expansion of Veterans Appeals Board 2Health News:Internet fuels virtual subculture for sex trade, study finds 2Health News:Re-define 'Thank-You' With Style and Value From Van's Gifts 2Health News:Statement by Dr. Daniel Carucci, Vice President for Global Health for the United Nations Foundation on the Launch of the State of the World's Vaccines and Immunization Report 2Health News:Statement by Dr. Daniel Carucci, Vice President for Global Health for the United Nations Foundation on the Launch of the State of the World's Vaccines and Immunization Report 3
(Date:8/28/2015)... , Aug. 28, 2015 ... has announced the addition of the "Investigation ... to their offering. Developed by Pharmacia ... prostaglandin receptor agonist which effectively reduces intraocular pressure. ... FDA, latanoprost (under the trade name of Xalatan) ...
(Date:8/28/2015)... The scientific team of a new ... the leading academics in the field of aging Prof. ... life extension for model animals - 10 fold for nematodes) ... age-related diseases, primarily, around the stability and stress resistance of ... as "Stability analysis of a model gene network links aging, ...
(Date:8/28/2015)... DUBLIN , Aug. 28, 2015 Perrigo ... commented on the Mylan N.V. ("Mylan") (NASDAQ: MYL ... acquire Perrigo. "Our views of Mylan,s offer ... to be, based on our Board,s careful reflection of ... depend on the limited choices that Mylan has allowed ...
Breaking Medicine Technology:China Latanoprost Market Investigation Report 2015-2019 2Gero: Physics Meets Biology to Help Defeat Aging 2Gero: Physics Meets Biology to Help Defeat Aging 3Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 2Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 3Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 4Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 5
... announces that a new market research report is ... Markets for Video, High-Tech and Integrated OT Equipment ... The European Markets for Video, High-Tech ... Austria, Benelux, France, Germany, Italy, Portugal, Scandinavia, Spain ...
... 14, 2010 Verenium Corporation (Nasdaq: VRNM ... high-performance industrial enzyme solutions, today announced key ... "2010 has been a significant year of ... oriented to being focused on building the next leading ...
Cached Medicine Technology:Reportlinker Adds European Markets for Video, High-Tech and Integrated OT Equipment 2011 2Reportlinker Adds European Markets for Video, High-Tech and Integrated OT Equipment 2011 3Reportlinker Adds European Markets for Video, High-Tech and Integrated OT Equipment 2011 4Reportlinker Adds European Markets for Video, High-Tech and Integrated OT Equipment 2011 5Reportlinker Adds European Markets for Video, High-Tech and Integrated OT Equipment 2011 6Reportlinker Adds European Markets for Video, High-Tech and Integrated OT Equipment 2011 7Reportlinker Adds European Markets for Video, High-Tech and Integrated OT Equipment 2011 8Reportlinker Adds European Markets for Video, High-Tech and Integrated OT Equipment 2011 9Reportlinker Adds European Markets for Video, High-Tech and Integrated OT Equipment 2011 10Reportlinker Adds European Markets for Video, High-Tech and Integrated OT Equipment 2011 11Reportlinker Adds European Markets for Video, High-Tech and Integrated OT Equipment 2011 12Reportlinker Adds European Markets for Video, High-Tech and Integrated OT Equipment 2011 13Reportlinker Adds European Markets for Video, High-Tech and Integrated OT Equipment 2011 14Reportlinker Adds European Markets for Video, High-Tech and Integrated OT Equipment 2011 15Reportlinker Adds European Markets for Video, High-Tech and Integrated OT Equipment 2011 16Reportlinker Adds European Markets for Video, High-Tech and Integrated OT Equipment 2011 17Reportlinker Adds European Markets for Video, High-Tech and Integrated OT Equipment 2011 18Reportlinker Adds European Markets for Video, High-Tech and Integrated OT Equipment 2011 19Verenium Announces 2010 Business Update and Outlook for 2011 2Verenium Announces 2010 Business Update and Outlook for 2011 3Verenium Announces 2010 Business Update and Outlook for 2011 4Verenium Announces 2010 Business Update and Outlook for 2011 5
Custom-made chisels....
9 inch sharp bone hook with grip handle....
Designed for proximal femoral elevation in total hip replacement or in other surgery with a similar need for bone manipulation....
Straight, single action bone forceps to excise, trim and sculpt bone....
Medicine Products: