Navigation Links
Scripps Research scientists show how shifts in temperature prime immune response
Date:5/6/2011

associate in the Patapoutian laboratory. "The temperature drops significantly when, say, immune cells move from the 37 degree Celsius temperature of the spleen to skin, where it is normally 33 degrees. During fever, core body temperature can rise to 41 degrees." Scientists have discussed for decades whether fever is beneficial to the immune system. The researchers believe that identification of a molecular sensor of temperature within immune cells provides a novel avenue to address such questions mechanistically.

The research team, which included Bertrand Coste and Jayanti Mathur, also of the Patapoutian lab, found that STIM1 can be activated by heat with a high degree of temperature sensitivity. Both STIM1 and a plasma membrane pore-forming protein known as Orai1 have recently been identified as essential components of the so-called the calcium release activated calcium (CRAC) channel. But STIM1 had not been known to be heat sensitive until this research, according to Xiao.

The process goes like this: STIM1 proteins are located on the ER, which is the organelle that stores calcium inside the cell. When a sudden change in temperature occurs, STIM1 proteins cluster together and translocate close to the plasma membrane. There, these clusters then can activate Orai1, which leads to the opening of the channel pore and an influx of calcium to activate the cell. Calcium is essential for a number of cellular functions, and, in immune cells, a sustained influx of calcium into these cells activates gene expression and cell proliferation. It turns the immune cell "on," Xiao said.

The function of STIM1 and Orai1 had already been known to be critical to immune function, Xiao said. Mutations in genes encoding either of the proteins lead to development of severe combined immunodeficiency (SCID), the so-called "bubble boy" disease characterized by a complete absence of immunity.

Given the relatively wide expression pattern of STIM1, the researc
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. CIRM awards Scripps Research Institute scientists $3.5 million
2. Scripps Research wins more than $2 million to study prostate cancer
3. New lupus drug results from Scripps Research technology
4. Scripps Research and MIT scientists discover class of potent anti-cancer compounds
5. Scripps Research study points to liver, not brain, as origin of Alzheimers plaques
6. Scripps Research compound blocks brain cell destruction in Parkinsons disease
7. Scripps Research scientists develop powerful new methodology for stabilizing proteins
8. Scripps Research scientists find measles natural nemesis
9. Scripps Research scientists awarded $2.35 million to study new obesity treatment
10. Scripps Research scientists identify first synthetic activator of 2 critical proteins
11. Scripps Clinic nurse to receive 2010 ASTRO Nurse Excellence Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... July 23, 2014 “Unlike most Sales ... on developing your own unique gifts, talents and abilities ... clichéd sales verbiage, “says Ja Marr Brown. ... Story?" which chronicles Brown’s transformation from nearly getting fired ... The Year, winning every sales contest offered and taking ...
(Date:7/23/2014)... Miami, FL (PRWEB) July 23, 2014 ... can pay higher premiums for life insurance based on ... a cheap life insurance rates search to its comprehensive ... pricing at http://quotespros.com/life-insurance.html . , Providers that ... be selected, sorted and reviewed in one or two ...
(Date:7/23/2014)... CA (PRWEB) July 23, 2014 Obtaining ... process for the average consumer. The Quotes Pros company ... for all 50 states this year to make research ... that are issuing the rates information are actual agencies ... plans underwritten inside the U.S. An advantage to adults ...
(Date:7/23/2014)... The age spots, wrinkles and puffy eyes that can be ... now explored in a new guide posted at the Cherry ... over 30 are introduced in the guide as well as ... of creams as an alternative to surgery is one method ... the information in the new guide. Because there are hundreds ...
(Date:7/23/2014)... (PRWEB) July 23, 2014 The puffiness ... diminished using non-surgical techniques, according to a new guide ... eyes serum sold in the U.S. is now available ... . , The complimentary guide that is now published ... struggle with under eye puffiness. While surgical techniques are ...
Breaking Medicine News(10 mins):Health News:Using Your Story and Not Technique to Achieve Sales Success 2Health News:Cheap Life Insurance Rates for Married Couples Added to Search System at Insurer Portal Online 2Health News:Term Life Insurance Prices for All 50 States Now Explored at Insurer Website 2Health News:Best Eye Creams for Women Over 30 Detailed in Published Guide at News Website Online 2Health News:Puffy Eyes Serum Explored in Complimentary Guide Released at Consumer News Website 2
... Opposition DebateCHESAPEAKE, Va., April 28 The following ... the necessary 60 votes required to pass socialized ... Democrats last night struck a back-room deal that ... drops the number of needed votes to 50 ...
... The Third Annual AmeriCorps Week (May 9-16) hopes ... are having across America every day. There are ... year, assisting at-risk youth, providing services for the ... nonprofits in volunteer recruitment and achieving their vision. ...
... Career School, one of the oldest and largest online ... Certified Personal Trainer Program.With Penn Foster,s Certified Personal Trainer ... and skills of a Personal Trainer plus a National ... contains materials that will prepare them for NCSF Certification. ...
... says, , , TUESDAY, April 28 (HealthDay News) -- Want to ... a healthy blood pressure level. , Each of those factors ... according to new research. , Although both factors had previously ... of the effect found in the new study was ...
... for Young Adults, Testing Rates Are StagnantAmidst Call for ... Support for More Spending and the Public Believes Greater ... Less than a year after the Centers for ... the HIV/AIDS epidemic and announced that there were 40 ...
... Managed care companies are the only sector of the ... is time for that to change.(Photo: ... (AMA) drafted language for a National Health Insurer Code ... autonomy, transparency, corporate integrity and patient safety and welfare. ...
Cached Medicine News:Health News:Fast-Track of Socialized Healthcare Imminent 2Health News:Third Annual AmeriCorps Week 2Health News:Third Annual AmeriCorps Week 3Health News:Penn Foster Career School Launches Online Certified Personal Trainer Program 2Health News:Smoking, Hypertension Each Account for 1 in 5 U.S. Deaths 2Health News:Less Than a Year After CDC Announced the U.S. HIV Epidemic Is Much Larger Than Previously Thought, Public's Sense of Urgency Is Down, Even Among Some Higher Risk Groups 2Health News:Less Than a Year After CDC Announced the U.S. HIV Epidemic Is Much Larger Than Previously Thought, Public's Sense of Urgency Is Down, Even Among Some Higher Risk Groups 3Health News:Less Than a Year After CDC Announced the U.S. HIV Epidemic Is Much Larger Than Previously Thought, Public's Sense of Urgency Is Down, Even Among Some Higher Risk Groups 4Health News:For Patients' Sake, Insurance Companies Urgently Need a Code of Conduct 2
(Date:7/23/2014)... 23, 2014 Today,s U.S. Food and ... patients with relapsed chronic lymphocytic leukemia (CLL), follicular ... a significant advance for patients with these blood ... the trade name Zydelig®, is a first-in-class inhibitor ... expressed in many B-cell malignancies and plays a ...
(Date:7/23/2014)... 2014  Varian Medical Systems (NYSE: VAR ... diluted share in the third quarter of fiscal year ... per diluted share due to an approximately $8 million ... equity investment in Augmenix, a privately-held company developing minimally ... million for the third quarter of fiscal year 2014, ...
(Date:7/23/2014)... NORWALK, Conn. , July 23, 2014 ... NeurologyTimes.com – a new online community and information ... them better manage and treat their patients with ... conditions, coupled with an aging population, necessitates greater access ... specific disorders.  Key statistics on neurological conditions include: ...
Breaking Medicine Technology:The Leukemia & Lymphoma Society Applauds FDA's Approval of Idelalisib To Treat Three Types of Blood Cancers 2Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 2Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 3Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 4Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 5Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 6Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 7Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 8Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 9Varian Medical Systems Reports Results for Third Quarter of Fiscal Year 2014 10UBM Medica US Launches NeurologyTimes.com 2UBM Medica US Launches NeurologyTimes.com 3
... Pharmaceuticals, Inc. (NYSE Amex: ANX ) today announced ... offer and sell shares of its common stock and warrants ...  The Company also intends to grant the underwriters a 45-day ... shares and warrants sold in the public offering to cover ...
... Food and Drug Administration has licensed HEMACORD™ (Hematopoietic ... cell transplantation, the first such approval of a ... According to the Food and Drug Administration,s ... is "indicated for use in unrelated donor hematopoietic ...
Cached Medicine Technology:ADVENTRX Announces Public Offering of Stock 2ADVENTRX Announces Public Offering of Stock 3FDA Approves New York Blood Center's HEMACORD™ for Stem Cell Transplantation 2FDA Approves New York Blood Center's HEMACORD™ for Stem Cell Transplantation 3
... Ultrapure MB Grade PRODUCT SPECIFICATIONS Form: Granular, free-flowing ... Gel Point (1.5%): 36.0 1.5C Remelt Point ... than or equal to 1,200 gm/cm 2 ... 2,500 gm/cm 2 Moisture: less than or ...
... traces: chloride (Cl) ≤ 3000 mg/kg sulfate (SO 4 ... mg/kg Cd ≤ 10 mg/kg Co ≤ 10 mg/kg ... ≤ 10 mg/kg K ≤ 500 mg/kg Mg ≤ ... mg/kg Ni ≤ 10 mg/kg Pb ≤ 10 mg/kg ...
... a multipurpose agarose, has been developed for ... and separation of high molecular weight DNA ... a high gel strength agarose ( 1800 ... the use of low concentrations of agarose ...
Inquire...
Medicine Products: