Navigation Links
Scripps Research scientists show how shifts in temperature prime immune response
Date:5/6/2011

LA JOLLA, CA May 6, 2011 Researchers at The Scripps Research Institute have found a temperature-sensing protein within immune cells that, when tripped, allows calcium to pour in and activate an immune response. This process can occur as temperature rises, such as during a fever, or when it fallssuch as when immune cells are "called" from the body's warm interior to a site of injury on cooler skin.

The study, recently published online ahead of print by Nature Chemical Biology, is the first to find such a sensor in immune cellsspecifically, in the T lymphocytes that play a central role in activation of killer immune cells. The protein, STIM1, previously known as an endoplasmic reticulum (ER) calcium sensor, had been thought to be important in immune function, and now the scientists show it is also a temperature sensor.

"Temperature has a profound effect on all biological processes including immune responses, but surprisingly little is known about molecules in immune cells that sense temperature sifts," said the study's principal investigator, Scripps Research Professor Ardem Patapoutian. "Here we show that STIM1 senses temperature and has a profound impact on immune cells."

This is the second family of thermosensation molecules that the Patapoutian laboratory has uncovered. The team has isolated and characterized three of six members of the transient receptor potential (TRP) family of ion channelsthe so-called thermoTRPs. "These proteins translate temperature, which is a physical stimulus, into a chemical signalions flowing into cells," said Patapoutian.

"ThermoTRPs mainly function in specialized sensory neurons that relay environmental temperature information to the brain."

In this study, the researchers turned to immune cells to look for temperature sensors. "Immune cells can experience dramatic temperature changes under either normal or pathophysiological conditions," said first author Bailong Xiao, a research
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. CIRM awards Scripps Research Institute scientists $3.5 million
2. Scripps Research wins more than $2 million to study prostate cancer
3. New lupus drug results from Scripps Research technology
4. Scripps Research and MIT scientists discover class of potent anti-cancer compounds
5. Scripps Research study points to liver, not brain, as origin of Alzheimers plaques
6. Scripps Research compound blocks brain cell destruction in Parkinsons disease
7. Scripps Research scientists develop powerful new methodology for stabilizing proteins
8. Scripps Research scientists find measles natural nemesis
9. Scripps Research scientists awarded $2.35 million to study new obesity treatment
10. Scripps Research scientists identify first synthetic activator of 2 critical proteins
11. Scripps Clinic nurse to receive 2010 ASTRO Nurse Excellence Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... The Incredible Bulk is a revolutionary method ... lean muscle by up to 30lbs in less than 12 ... HealthyandFitZone.com’s Stan Stevenson, prompting an investigative review. , “Our ... scientific diet formula that allows the body to pack on ...
(Date:1/22/2015)... Juvent Sports ( http://www.juventsports.com ) and David Leadbetter ... to bestow a Juvent Sports Achievement award upon an ... The award commemorated and congratulated McKitrick for her record ... her first amateur tournament in 1979 and most recently ...
(Date:1/22/2015)... released a new blog post presenting the basic features of ... an accidental death and dismemberment rider for a car insurance ... benefits if the insured dies in an accident. Accidental death ... insurance. , AD&D is not expensive and can be ...
(Date:1/22/2015)... Florida (PRWEB) January 22, 2015 IsoComforter, Inc. ... therapy machine with patented IsoTube design to treat specific body ... introduced the most progressive and easy to use patented cold ... post-operative and sports related orthopedic and muscle injuries. IsoComforter ...
(Date:1/22/2015)... January 22, 2015 JJsHouse.com is a famous ... Today, the business announces its latest collection of wedding ... “The most important issue is the wedding dress on your ... in a woman’s life. Every bride wants to find the ...
Breaking Medicine News(10 mins):Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2
... Joins RiskMetrics and Glass Lewis in Urging Stockholders to ... (Nasdaq: LCAV ) announces that the independent ... Group,s ISS Governance Services and Glass Lewis & Co., ... the Company,s current management and Board of Directors and ...
... Weight NAPLES, Fla., March 11 -The owners of MAKE ... are helping all Hoosiers begin building healthier lifestyles in 2009 ... and Rebecca Johnson are offering all residents of the Hoosier ... 99 cents a month if they sign up during the ...
... PA, March 11 /PRNewswire-FirstCall/ - DiagnoCure Oncology Laboratories, ... Colorectal Cancer Staging Test, launches an interactive website ... friends. www.mypersonalcancerdiagnosis.com provides key information to ... advanced genomic technologies for managing colorectal cancer. These ...
... few years, millions of consumers have begun taking ... of improving their cardiovascular health. Recent studies like the ... American Heart Journal indicate that the omega-3,s in fish ... unknown health benefits. Last year European sports medicine experts ...
... BOTHELL, Wash., March 11 Cardiac Science (Nasdaq: ... advanced cardiac diagnosis, resuscitation, rehabilitation, and informatics products, ... Washington Biotechnology and Biomedical Association (WBBA) 2009 Invest ... Harbor International Conference Center in Seattle. Michael Matysik, ...
... Level I validation for Postoperative Nausea and Vomiting (PONV)CORONA ... available in 1983, making each patient,s oxygen status known ... American Society of Anesthesiologists (ASA) say that all patients ... safety subject appear in the ASA Newsletter on their ...
Cached Medicine News:Health News:Three Leading Proxy Advisory Firms are Unanimous in Recommending LCA-Vision Stockholders Support the Current Board of Directors 2Health News:Three Leading Proxy Advisory Firms are Unanimous in Recommending LCA-Vision Stockholders Support the Current Board of Directors 3Health News:Three Leading Proxy Advisory Firms are Unanimous in Recommending LCA-Vision Stockholders Support the Current Board of Directors 4Health News:Make It Fit America Inc. Offers Virtually Free Fitness Service on 'Make Indiana Fit Day' 2Health News:Make It Fit America Inc. Offers Virtually Free Fitness Service on 'Make Indiana Fit Day' 3Health News:New website empowers colorectal cancer patients when discussing critical treatment decisions - DiagnoCure launches www.mypersonalcancerdiagnosis.com 2Health News:New website empowers colorectal cancer patients when discussing critical treatment decisions - DiagnoCure launches www.mypersonalcancerdiagnosis.com 3Health News:New website empowers colorectal cancer patients when discussing critical treatment decisions - DiagnoCure launches www.mypersonalcancerdiagnosis.com 4Health News:New website empowers colorectal cancer patients when discussing critical treatment decisions - DiagnoCure launches www.mypersonalcancerdiagnosis.com 5Health News:Olympic Gold Winning Supplement Lands in the US 2Health News:Cardiac Science to Present at the Eighth Annual Invest Northwest Conference 2Health News:American Society of Anesthesiologists (ASA) - Myths About 'Never Ending Pursuit of Patient Safety and Satisfaction' Debunked 2
(Date:1/23/2015)... 2015 A lot of discussion in the medical community ... illnesses, injuries, or conditions. As medical science advances, doctors and ... ones that they consider to be more cutting edge. Yet, ... textbook method of treatment that stands out as the best ...
(Date:1/23/2015)... BETHESDA, Md. , Jan. 23, 2015  Northwest Biotherapeutics, Inc. ... developing DCVax® personalized immune therapies for operable and inoperable solid ... will present at the 7 th Annual Phacilitate Immunotherapy ... NW Bio,s presentation at Phacilitate will take place on January ...
(Date:1/23/2015)... , Jan. 23, 2015 /PRNewswire/-- Harwood Feffer LLP ( www.hfesq.com ... directors of Advaxis, Inc. ("Advaxis" or the "Company") (NASDAQ: ... breached its fiduciary duties to shareholders. On ... investing website reporting that Advaxis had misrepresented the clinical ...
Breaking Medicine Technology:No One-Size-Fits-All Remedy for Hernia Correction 2NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 2NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 3Harwood Feffer LLP Announces Investigation of Advaxis, Inc. 2
... Feb. 24, 2011 /PRNewswire-Asia-FirstCall/ -- Sanofi-aventis (EURONEXT: SAN; NYSE: ... completed the previously announced acquisition of BMP Sunstone Corporation ... today, BMP Sunstone stockholders approved the adoption of the ... Inc., a wholly owned subsidiary of sanofi-aventis, dated October ...
... BrainScope Company, Inc. today announced that Peter ... Medical Advisory Board.  He holds the distinguished title ... the University of Edinburgh, Scotland, United Kingdom.  This ... is entering the U.K. market with its "B-Ahead ...
Cached Medicine Technology:Sanofi-Aventis Announces Approval and Closing of BMP Sunstone Acquisition Creating a Strong Consumer Health Care Platform in China 2BrainScope® Announces Appointment of Professor Peter Andrews, MD to Its Medical Advisory Board 2BrainScope® Announces Appointment of Professor Peter Andrews, MD to Its Medical Advisory Board 3BrainScope® Announces Appointment of Professor Peter Andrews, MD to Its Medical Advisory Board 4
... TME 227 T is a ... temporary cardiac pacing and monitoring ... The TME 227 T features ... myocardium, which allows safe and ...
For temporary cardiac pacing after open heart surgery. The zig-zag portion of the heartwire is embedded into the desired area of the myocardium (epicardially)....
For temporary cardiac pacing after open heart surgery. The zig-zag portion of the heartwire is embedded into the desired area of the myocardium (epicardially)....
For temporary cardiac pacing after open heart surgery. The zig-zag portion of the heartwire is embedded into the desired area of the myocardium (epicardially)....
Medicine Products: