Navigation Links
Scripps Research scientists show how memory B cells stay 'in class' to fight different infections
Date:5/7/2012

ory cells, they become dysfunctional and die," Wang said.

The finding that T-bet has this all-important, ongoing function in IgG2a memory cells suggested that other proteins play analogous roles in other classes of memory B cell. Wang therefore turned to memory B cells of the IgA class, and, with a similar set of experiments, showed that these memory B cells depend on the transcription factor RORα. "It essentially does for IgA memory cells what T-bet does for IgG2a memory cells," said Wang.

Implications for Science and Medicine

Wang and McHeyzer-Williams and their colleagues are now searching for the proteins that keep other memory B cells healthy and in their classes. But already the work has clarified how memory B cells work. "Until now we haven't really had a good conceptual framework for the development and maintenance of these cells," McHeyzer-Williams said.

The findings clearly also have implications for medicine. By supplying a particular class-enforcement protein at the same time that it exposes B cells to microbial proteins, a vaccine could induce a long-term immunity that is heavily weighted towards a desired antibody class. "If you're designing a vaccine for certain types of virus, for example, you would like to have lots of IgG2a and IgA memory cells," said McHeyzer-Williams. "So the goal would be to design a chemical adjuvant for the vaccine that drives B cells into those classes."

Similarly, therapies that knock down class-enforcement signals such as T-bet could usefully reduce or eliminate memory B cells in certain classes. "Some autoimmune, allergic and lymphoma conditions are driven by B cells of a particular class, for example IgE cells in allergies," said McHeyzer-Williams. "Being able to target just that class of B cell would be an obvious advantage over existing therapies, such as steroids, that knock down large parts of the immune system."


'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Scripps Health Begins Pioneering Study of Human Tumor Sequencing in Cancer Patients
2. Top Scientists Explore the Origin of Life in Annual Lasker Lecture at Scripps Research Institute Florida Campus
3. Scripps Blood & Marrow Transplant Program Celebrates 30th Anniversary of Providing Life-Saving Care
4. Scripps Memorial Hospital La Jolla First in San Diego to Achieve Magnet Nursing Re-designation
5. Scripps Announces Plans for Region's First Proton Therapy Center; $185 Million Facility to Offer Advanced Care to Cancer Patients
6. Scripps Research scientists share $2 million in Florida state research grants
7. Scripps Center for Executive Health Now Offers Genetic Testing
8. Scripps Research scientists uncover previously unknown natural mechanism that controls cocaine use
9. NIH awards Scripps Florida scientists $2.3 Million to develop drug addiction treatments
10. Scripps Research scientists solve long-standing mystery of protein quality control mechanism
11. Scripps and Trius team up to develop new antibiotics with US Department of Defense grant
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research scientists show how memory B cells stay 'in class' to fight different infections
(Date:9/19/2014)... caused by the bacterium Mycobacterium avium ... legal obligation to report the disease. Paratuberculosis mainly ... among affected animals. The disease can cause considerable ... less milk, exhibit fertility problems and are more ... , To date there has been no ...
(Date:9/19/2014)... September 19, 2014 Lifeinsure.biz has ... insurance riders that can be purchased without medical examinations. ... up and make a life insurance policy more advantageous. ... find more about extra options available for a no ... without medical examinations required is simple to purchase, however ...
(Date:9/19/2014)... 19, 2014 2014 Market Research ... professional and in-depth research report on Kinesio tape ... its definition, classification, application, and industry chain structure ... the international market analysis, including China’s domestic market ... environment & economic situation analysis. The report on, ...
(Date:9/19/2014)... York (PRWEB) September 19, 2014 Business ... Game Building Platform . Earlier this month Appy Pie was ... Tools for the Aspiring App Developer' by Yahoo . , ... allows people to develop beautiful applications within minutes and it ... With advanced features and support for latest mobile operating systems, ...
(Date:9/19/2014)... The dentist at Encino Esthetic Dental Group ... the month of September, new patients will be able to ... $69. A complimentary home teeth whitening kit will be included. ... checked and meet the team at Encino Esthetic Dental Group. ... oral health. According to the American Dental Association, biannual checkups ...
Breaking Medicine News(10 mins):Health News:Lymphatic fluid used for first time to detect bovine paratuberculosis 2Health News:No Medical Exam Life Insurance - Lifeinsure.biz Presents 5 Important Riders! 2Health News:Kinesio Tape Industry Analysis for North America, Europe, Asia & ROW Key Company Market Status Now at LifeScienceIndustryResearch.com 2Health News:Kinesio Tape Industry Analysis for North America, Europe, Asia & ROW Key Company Market Status Now at LifeScienceIndustryResearch.com 3Health News:Business Insider Australia Rates Appy Pie as a top App & Game Building Platform 2Health News:Encino Esthetic Dental Group is Now Offering a Special Promotion for New Patients 2
... Cancer ... President, Nutrition, National Cattlemen,s ... Beef Association, DENVER, Oct. 31 "The WCRF/AICR recommendations about,red ... research about the benefits of red meat in a healthy,diet that far outweigh anything ...
... will Accelerate Expansion of Industry Leading Health and Human ... Services On-Demand Software Solutions, ... industry-leading provider of software solutions for the,health and human services ... and debt financing totaling $28 million. The round was led,by ...
... a 70-cm Open-Bore, Design to Bring High-Resolution MR Imaging to ... ... Before, MALVERN, Pa., Oct. 31 Combining 3 Tesla strength and,sensitivity ... the MAGNETOM(R),Verio, a 3 Tesla (T) MRI system with a 70 cm ...
... encourage health behavior change increasing, LYNDHURST, N.J., ... the 3rd quarter of 2007, with agreements to ... at initial rollout,six million when programs are fully ... Health and Productivity division, which combines the use,of ...
... even Alzheimer,s, experts say , , WEDNESDAY, Oct. 31 (HealthDay News) ... brain,s own stem cells may have the ability to restore ... by protecting existing cells and promoting neuronal connections. , In ... were able to bring the rodents, memory back to healthy ...
... for hepatocytes; viral antigen also has been detected in ... hepatic failure but rarely reported in acute viral hepatitis. ... three year period were involved. Acute abdominal pain was ... 17 had stretching of glissons capsule as a cause. ...
Cached Medicine News:Health News:NCBA Statement on 2007 WCRF/AICR Second Expert Report on Food, Nutrition and Physical Activity and the Prevention of Cancer: 2Health News:Harmony Information Systems Raises $28 Million in Series B Financing from JMI Equity, Updata Partners, ORIX Venture Finance and Comerica Bank 2Health News:Harmony Information Systems Raises $28 Million in Series B Financing from JMI Equity, Updata Partners, ORIX Venture Finance and Comerica Bank 3Health News:Harmony Information Systems Raises $28 Million in Series B Financing from JMI Equity, Updata Partners, ORIX Venture Finance and Comerica Bank 4Health News:3 Tesla + 70 cm + Tim = The Most Exciting Equation in MRI 2Health News:3 Tesla + 70 cm + Tim = The Most Exciting Equation in MRI 3Health News:3 Tesla + 70 cm + Tim = The Most Exciting Equation in MRI 4Health News:IncentOne Adds 14 New Clients Year to Date to Health and Productivity Division 2Health News:IncentOne Adds 14 New Clients Year to Date to Health and Productivity Division 3Health News:Stem Cells Restore Memory in Mice 2Health News:Stem Cells Restore Memory in Mice 3Health News:Is it pancreatitis in acute abdominal pain in acute viral hepatitis? 2
(Date:9/18/2014)... -- Research and Markets has announced the ... Report, 2014-2016" report to their offering. ... percutaneous coronary intervention (PCI), serves not only as a ... for pre-/post-stent dilatations. Therefore, the development of PTCA balloon ... As national economy develops and people,s living standard ...
(Date:9/18/2014)... 2014   Fruit Street Health (Fruit Street), ... round of funding. The round, which ... series of individual investors, the majority of whom are ... initial round are; Houston Cardiology Consultants Partner Asif ... Childs, Rapha Family Medicine Practice Owner Frances Ilozue ...
(Date:9/18/2014)... 2014  Decision Resources Group finds that Regeneron,s Eylea, ... agent for wet AMD, is equally likely to be ... Lucentis, which is the standard of care for wet ... directors do not identify a clear clinical or economic ... Lucentis to be listed on tier 1 or 2 ...
Breaking Medicine Technology:China PTCA Balloon Market Investment Report, 2014-2016 2China PTCA Balloon Market Investment Report, 2014-2016 3Fruit Street Health Secures First Round Of Seed Funding Led By Group Of Medical Industry And Technology Leaders 2Fruit Street Health Secures First Round Of Seed Funding Led By Group Of Medical Industry And Technology Leaders 3Regeneron's Eylea and Genentech's Lucentis Are Equally Likely to be Covered on Commercial and Medicare Advantage Plans for Wet AMD 2Regeneron's Eylea and Genentech's Lucentis Are Equally Likely to be Covered on Commercial and Medicare Advantage Plans for Wet AMD 3
Malaria Pf. Assay Range...
An immunochromatographic rapid test for the detection of Plasmodium falciparum in whole blood....
... Uni-Gold™ Pf Malaria Test is a ... presence of Plasmodium falciparum ... an antigen-capture assay detecting presence of ... protein II (PfHRP- II), which is ...
High sensitive, specific one step immunochromatographic assay for human infectious disease...
Medicine Products: