Navigation Links
Scripps Research scientists reveal key structure from ebola virus
Date:12/8/2009

LA JOLLA, CA, December 7, 2009Scientists at The Scripps Research Institute have determined the structure of a critical protein from the Ebola virus, which, though rare, is one of the deadliest viruses on the planet killing between 50 and 90 percent of those infected. Described in the advance, online Early Edition of the journal Proceedings of the National Academy of Sciences (PNAS), the research reveals how a key component of the Ebola virus, called VP35, blocks the human immune system, allowing the virus uncontrolled replication. The structure represents a major step forward in understanding how the deadly virus works, and may be useful in the development of potential treatments for those infected.

"After infection, the virus and immune system are in a race," said Erica Ollmann Saphire, Ph.D., associate professor at Scripps Research, who led the three-year effort to solve the structure. "If the virus can hide its molecular signatures, it can suppress immune responses and replicate unchecked. This new understanding of the mechanism that Ebola virus uses to evade the immune system opens the door for developing drug therapies."

A signature of Ebola virus infection is the presence of the virus's double-stranded RNA, which, when detected by immune system proteins, triggers a full immune response. The new research describes how the VP35 protein of the Ebola virus masks the double-stranded RNA to prevent the immune response.

The protein structure, determined by X-ray crystallography, showed that VP35 binds another copy of itself, and the pair cooperatively masks the RNA ends. Christopher Kimberlin, the first author of this study, explained that this assembly is unusual because each member of the pair binds the RNA in a different way, revealing that VP35 has two unique strategies for masking viral signatures. Importantly, the interface between the two VP35 molecules provides a new target for drugs that would stop Ebola virus infection and allow the immune system to clear the infection. Additional RNA binding, small angle X-ray scattering, and deuterium exchange mass spectrometry experiments confirm the cooperative function of these molecules for immunosuppression.

There is currently no cure for Ebola hemorrhagic fever. The virus is spread when people come into contact with the bodily fluids of an infected person or animal. Most die from a combination of dehydration, massive bleeding, and shock. There is currently no vaccine or drug therapy for Ebola infection, but the findings of this study may lead to new treatments.


'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Related medicine news :

1. Scripps Research scientists shed new light on how antibodies fight HIV
2. Scripps Health Treats More Than 160 Fire Victims at Emergency Departments Across San Diego County
3. Scripps research scientists discover chemical triggers for aggression in mice
4. Scripps research scientists find new genetic mutation that halts the development of lupus
5. Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells
6. Scripps scientists peg wind as the force behind fish booms and busts
7. Scripps research scientists devise approach that stops HIV at earliest stage of infection
8. Scripps Florida awarded $7.6 million grant to develop novel treatment for Parkinsons disease
9. Scripps research team wins $4M grant to study effects of chronic marijuana use
10. Scripps Florida scientists develop a process to disrupt hepatitis C virion production
11. Scripps Memorial Hospital Nurses Throw Out CNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... (PRWEB) , ... January 17, 2017 , ... Livionex, Inc., ... results of a double blind clinical study for its dental gel that shows significant ... national brand of toothpaste containing triclosan. The study was conducted at the Beckman Laser ...
(Date:1/17/2017)... ... 2017 , ... The Sharie Withers Agency, a full-service insurance ... beneficiary of their thriving community involvement program. The current campaign fundraises to support ... of terminally ill patients. Donations to this worthy cause may now be made ...
(Date:1/17/2017)... ... ... Today, FloSports , a global leader in live digital sports and original ... long-term extension of their media partnership. The partnership, which began in 2013, will now ... events exclusively on FloWrestling.com as well as usage of the FloArena meet management software ...
(Date:1/16/2017)... (PRWEB) , ... January 17, 2017 , ... Recently, patients ... in Southwest Michigan, joined other volunteers and organizations in support of the annual Binder ... children and families dressed up in colorful costumes of all designs coming out to ...
(Date:1/16/2017)... ... January 16, 2017 , ... Etymotic Research, makers ... and EB15•LE® electronic earplugs at the NSSF SHOT Show on January 17-20, 2017 ... SHOT Show is the shooting, hunting and outdoor trade show and conference for ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... , Jan. 16, 2017 ... Market Outlook to 2022", provides key market data on ... value, in millions of US dollars, volume (in units) ... Energy X-Ray Absorptiometry (DEXA) and Quantitative Ultrasound (QUS). ... data for each of these market segements, and global ...
(Date:1/16/2017)... , Jan. 16, 2017 Infusion ... devices used for administering medications in a controlled, ... used for therapeutic purposes in critical care, pain ... required to make patient,s feel comfortable and pain ... errors which would lead to serious life threatening ...
(Date:1/16/2017)... BOTHELL, Wash. , Jan. 16, 2017  Verathon ® ... devices, announced the launch of new GlideScope ® Spectrum TM ... all-new Dynamic Light Control TM and Ambient Light Reduction TM ... Continue Reading ... ...
Breaking Medicine Technology: