Navigation Links
Scripps Research scientists reveal how white blood cell promotes growth and spread of cancer
Date:8/31/2011

LA JOLLA, CA August 31, 2011 - Scientists at The Scripps Research Institute have shown that a particular white blood cell plays a direct role in the development and spread of cancerous tumors. Their work sheds new light on the development of the disease and points toward novel strategies for treating early-stage cancers.

The study was published in September 2011 print issue of the American Journal of Pathology.

Scripps Research Professor James Quigley, Staff Scientist Elena Deryugina, and colleagues had previously demonstrated that white blood cells known as neutrophilsbone marrow-derived cells that function as "first responders" at sites of acute inflammationpromote the growth of new blood vessels in normal, healthy tissue.

The team has now tied these cells to the induction and growth of new blood vessels in malignant tumors and to the spread of tumor cells through those newly formed vessels. The scientists have also uncovered some of the mechanisms underpinning this processwhich could be interrupted by properly targeted drugs.

Potent and Uninhibited

The Scripps Research team has been particularly interested in neutrophils, in part because several studies have demonstrated a link between elevated neutrophil levels and high rates of tumor invasion among cancer patients. Mounting evidence has also indicated that neutrophils play a particularly important role during the early stages of tumor development.

"During tumor development, neutrophils appear to be one of the first inflammatory cell types on the scene," said Deryugina, who spearheaded the new study.

The researchers have been especially interested in the blood vessel-forming or "angiogenic," powers of neutrophils, which stem from a special enzyme they produce known as MMP-9 (matrix metalloproteinase type 9). The enzyme is, in fact, synthesized by a number of different types of white blood cells and has long been linked to tumo
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Scripps Research scientists define cellular pathway essential to removing damaged mitochondria
2. Scripps Translational Science Institute joins Jackson Laboratory tumor consortium
3. Scripps Research scientists show how shifts in temperature prime immune response
4. CIRM awards Scripps Research Institute scientists $3.5 million
5. Scripps Research wins more than $2 million to study prostate cancer
6. New lupus drug results from Scripps Research technology
7. Scripps Research and MIT scientists discover class of potent anti-cancer compounds
8. Scripps Research study points to liver, not brain, as origin of Alzheimers plaques
9. Scripps Research compound blocks brain cell destruction in Parkinsons disease
10. Scripps Research scientists develop powerful new methodology for stabilizing proteins
11. Scripps Research scientists find measles natural nemesis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2013)... Orlando, FL (May 18, 2013) The use ... for a colonoscopy, according to new research presented ... process, which begins days in advance of the ... preparation medication to be taken at strict intervals. ... for doctors to see cancer and precancerous polyps ...
(Date:5/18/2013)... of coffee is associated with a reduced risk ... disease, Mayo Clinic research shows. The findings were ... conference in Orlando, Fla. , PSC is ... results in inflammation and subsequent fibrosis that can ... and biliary cancer. , "While rare, PSC has ...
(Date:5/18/2013)... Hayden, ID (PRWEB) May 18, 2013 ... needs when it comes to safety and comfort ... these requirements and provides clients with an effective ... System®. This is an integrated, turnkey communications ... of care, while allowing residents independence and privacy. ...
(Date:5/18/2013)... Utah (PRWEB) May 18, 2013 ... on insurance agents’ role in Marketplaces . ... to traditional employer sponsored health benefits, is the ... and health reimbursement arrangements . , ... Health and Human Services (HHS) recently released a ...
(Date:5/18/2013)... Springs, FL (PRWEB) May 18, 2013 The ... dedicated to the special places we call home. These are ... on maps. They are the locations where the people are ... first-rate show takes viewers off the highways and shares the ... best of both nations with an American sports and film ...
Breaking Medicine News(10 mins):Health News:New smartphone application improves colonoscopy preparation 2Health News:VisionLink Nurse Call System's New Features Serve the Unique Needs of Retirement Communities 2Health News:VisionLink Nurse Call System's New Features Serve the Unique Needs of Retirement Communities 3Health News:Zane Benefits Publishes New Information on Insurance Agents’ Role in Marketplaces 2Health News:Zane Benefits Publishes New Information on Insurance Agents’ Role in Marketplaces 3Health News:Zane Benefits Publishes New Information on Insurance Agents’ Role in Marketplaces 4Health News:Communities of Distinction TV Presents "A Place to Call Home" Segment 2
... the seat of the Polish government Friday in support of ... of the building in a two-week pay protest. ... Silesian coal belt, brandished banners reading, "We want a decent ... ,Ringed by riot police, the demonstrators mingled with ...
... more likely to suffer heart attacks, according to a ... Bhopal and Colin Fischbacher at the University of Edinburgh, however, ... in comparison to their non-Asian countrymen. ,As part ... groups from the 2001 Census to Scottish hospital discharge and ...
... Britney Spears has openly confessed that she had sex with former ... until she was married. ,"I've only slept with ... into my relationship with Justin, and I thought he was the ... a magazine The most painful thing I have ever experienced ...
... the web are all pass, for the latest way to bag ... ,This new trend is a blessing for many singleton smokers ... a cigarette. ,This blend of smoking and flirting developed ... introduced, reports The Sun. ,The Irish were the first ...
... identified one unifying principle that could explain how a range ... for the cause of depression has implicated so many suspects ... condition remains an enigma. ,They found that ... treatment in the end appear to funnel through a single ...
... Saturday announced new measures aimed at curbing an epidemic ... prove elusive . ,China plans to set ... by the end of the year and to implement ... was quoted by the official Xinhua news agency as ...
Cached Medicine News:Health News:Trade Unionists Join Polish Nurses' Protest 2Health News:Brain Pathway for Depression Revealed 2Health News:Brain Pathway for Depression Revealed 3Health News:Top China Official Pessimistic on Fixing Food Safety Woes 2
(Date:5/17/2013)...  Lakeland Industries, Inc. (NASDAQ: LAKE ), ... healthcare and to first responders on the federal, state ... the fiscal 2013 fourth quarter and year ended January ... market close and will conduct a conference call on ... (Logo: http://photos.prnewswire.com/prnh/20120611/NY21959LOGO ) The call ...
(Date:5/17/2013)... Therapeutics, Inc. (Nasdaq: OREX ) today announced that ... Healthcare Conference in New York . The ... 11 a.m. Eastern Time. To listen to the live webcast ... Relations section of the Company,s Web site at www.orexigen.com ... the event. About Orexigen® Therapeutics Orexigen Therapeutics, ...
(Date:5/17/2013)... and CAMBRIDGE, Mass., May 17, 2013   Shareholder ... purchaser of Aveo Pharmaceutical, Inc. (NASDAQGS: AVEO) securities has ... the District of Massachusetts .  The ... violated the Securities Exchange Act of 1934 (the "Exchange ... (the "Class Period"). (Logo: http://photos.prnewswire.com/prnh/20130103/MM36754LOGO ) ...
Breaking Medicine Technology:Lakeland Industries to Report Fiscal Fourth Quarter and Year End Financial Results and Conduct Conference Call 2Aveo Pharmaceuticals, Inc. Sued by Investor 2Aveo Pharmaceuticals, Inc. Sued by Investor 3
A "doughy" type of bone cement intended for manual application....
... The Videoscopes provide superior image quality ... to the camera head with a ... ensures more light at the operative ... optimum image clarity and reliability.,The Videoscopes ...
... a wide range of innovative features, including ... Control (U.S. Patent #4,684,227). Stereopsis is maximized ... Heine's unique Diffuser aperture absorbs only 30% ... and simplifying difficult examinations. A newly incorporated ...
... 3-wire patient cable and 4 ... of the unit. 3-step procedure enabling ... 8 or 12 lead ECG through ... position. Records 2.5 seconds per lead ...
Medicine Products: