Navigation Links
Scripps Research scientists identify new class of antimalarial compounds
Date:11/17/2011

ompounds was especially attractive because it was chemically unrelated to existing antimalarial drugs, and therefore less likely to run into problems with existing resistance. "I wouldn't want to base a multimillion dollar clinical trial on compounds for which there may be pre-existing resistance," said Winzeler. "Ultimately, we want to have something that will still be effective in 10 years."

The group used an automated system of their own design to see how these new compounds fared against malaria parasites incubated in liver cells in the lab. An imaging apparatus took multiple images of each collection of cells over time, and a computer script analyzed those images to see how well the various compounds inhibited the growth of the parasites.

In the end, the team was able to develop compounds that could be taken orally and would stay in the blood long enough to be a viable candidate for drug development. When it was given to mice, the compound provided complete protection against the parasite in the liver, and worked better in the blood than some commercially available drugs.

Spurring Drug Discovery

To better understand how the compound works, the team exposed successive generations of infected mosquitoes to low levels of the compound to produce resistant strains of parasites. They then sequenced the parasites' whole genomes and looked for genetic changes. "Every [resistant] strain we looked at had a mutation in the same gene," she said.

By offering a target for other new antimalarial drugs that can act in both the liver and the blood, that gene will provide other researchers fresh ammunition in the fight to eradicate the disease. So, too, will the decision by the team to make all of their data available online.

"We have been making all of our data available to the community to spur drug development," Winzeler said. "The data on all of the compounds that were tested will eventually be released, and this
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Scripps Research scientist receives $1 million research grant from Novo Nordisk
2. Scripps Florida scientist awarded $2.2 million grant to study hepatitis C
3. Scripps research scientist wins $3.6 million NIH Method to Extend Research in Time award to study alcoholism in Native Americans
4. Scripps Health and Sanford-Burnham to collaborate to advance new cancer treatments
5. Scripps Research scientists reveal how white blood cell promotes growth and spread of cancer
6. Scripps Research scientists define cellular pathway essential to removing damaged mitochondria
7. Scripps Translational Science Institute joins Jackson Laboratory tumor consortium
8. Scripps Research scientists show how shifts in temperature prime immune response
9. CIRM awards Scripps Research Institute scientists $3.5 million
10. Scripps Research wins more than $2 million to study prostate cancer
11. New lupus drug results from Scripps Research technology
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research scientists identify new class of antimalarial compounds
(Date:10/20/2014)... Women’s health specialist, Dr. Amber Murphy, ... of Columbus, Inc., A Division of MaternOhio Clinical Associates, ... than 100,000 patients annually. Dr. Murphy will provide a ... of a women’s life. She is accepting new patients ... and Dublin. , Dr. Murphy offers a wide variety ...
(Date:10/20/2014)... Kennewick, WA (PRWEB) October 20, 2014 ... new workflow management software application. The new module ... ensure patients receive full life-cycle quality care. , This ... to others within their practice, attach a to-do item ... see fit, and even set up reoccurring reminders for ...
(Date:10/20/2014)... Oregon (PRWEB) October 20, 2014 Succeed is ... of local companies who participated in the Every Body ... is a public awareness project that encourages workers to be ... Summer Step 10,000 Program, which concluded at the end of ... variety of cities and metro areas. Participating companies gave ...
(Date:10/20/2014)... hard to imagine what it’s like to live without shoes, ... it’s a reality. And while new shoes are considered a ... barefoot on rocky terrain or sewage-lined streets just to collect ... , Buckner International's Shoes for Orphan Souls project ... encourage support for Air1 and while also providing new shoes ...
(Date:10/19/2014)... (PRWEB) October 20, 2014 The ... iPage ( http://www.top10bestseohosting.com/go/iPage/ ) and GreenGeeks are the ... excellent platforms for those who want to buy ... same time. , The IT manager of Top10BestSEOHosting.com ... the most recommended suppliers for everyone. A lot ...
Breaking Medicine News(10 mins):Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 2Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 3Health News:My Clients Plus Announces New Workflow Management Software 2Health News:Succeed Management Solutions, LLC Competes in Walking Challenge and Achieves 12th Place in Portland 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 3Health News:Top10BestSEOHosting.com Considers iPage And GreenGeeks As The Best Dedicated Server Hosting Suppliers 2
... Lunch Kill You?" Protest Shines Spotlight on Need for New Meat Regulations , ... , , ... ... WASHINGTON , March 18 ...
... High levels in men appear to be beneficial, study ... have found evidence that older men with higher levels ... or improper blood-sugar metabolism. , Tasnime Akbaraly, from the ... French adults for nine years, checking their levels of ...
... a new health education program to promote sound "mind and body" health practices among individuals who live with serious mental illness. , ... , ... ... ...
... who is a direct target of sexism, there are others ... of one sexist man affect how female bystanders feel and ... from the University of Connecticut in the US, publish their ... to sexism in Springer,s journal Sex Roles . ...
... ... Performance, Resilience, and Management. , ... Santa Clara, CA (PRWEB) March 18, 2010 -- NHS ... across the county, has completed the deployment of Aerohive Networks’ award-winning ...
... ... of Directive 98/79/EC on in vitro diagnostic medical devices. , ... Madison, WI (PRWEB) March 18, 2010 -- The Promega ... Directive 98/79/EC on in vitro diagnostic medical devices. The CE mark applies to the instrument, ...
Cached Medicine News:Health News:Victims of Contaminated Meat Call on USDA to Address Deadly Pathogens 2Health News:Victims of Contaminated Meat Call on USDA to Address Deadly Pathogens 3Health News:'Hearts and Minds' Promotes Wellness; African Americans Living with Mental Illness Have Higher Risk for Other Illnesses. 2Health News:'Hearts and Minds' Promotes Wellness; African Americans Living with Mental Illness Have Higher Risk for Other Illnesses. 3Health News:'Hearts and Minds' Promotes Wellness; African Americans Living with Mental Illness Have Higher Risk for Other Illnesses. 4Health News:'Hearts and Minds' Promotes Wellness; African Americans Living with Mental Illness Have Higher Risk for Other Illnesses. 5Health News:Cat-calls are detrimental to everyone 2Health News:NHS Lincolnshire Applies Intuitive ‘Cooperative Control' Wireless LAN 2Health News:NHS Lincolnshire Applies Intuitive ‘Cooperative Control' Wireless LAN 3Health News:Promega Maxwell 16 IVD System CE Marked to the European Union IVD Directive Delivers Combined Solution for Infectious Disease 2
(Date:10/20/2014)... , Oct. 20, 2014  Luoxis Diagnostics, Inc., ... AMPE), today announced that its academic collaborators will ... research potential for its novel RedoxSYS Diagnostic System, ... in the body in response to injury or ... ORP as a clinical marker will be presented ...
(Date:10/20/2014)... 2014   Taiho Oncology, Inc. , a ... Japan ), announced that the U.S. Food ... for TAS-102 (nonproprietary names: trifluridine and tipiracil hydrochloride), ... the treatment of refractory metastatic colorectal cancer (mCRC), ... NDA submission to the FDA. According to the ...
(Date:10/20/2014)... and RALEIGH, N.C., Oct. 20, 2014 /PRNewswire/ ... Neuropathy Foundation (HNF), both philanthropies, announced today the ... candidates for the treatment of the rare disease ... BioPontis Alliance announced its alliance model earlier this ... first demonstration of a collaborative model where researchers ...
Breaking Medicine Technology:Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 2Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 3Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 4Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 5Taiho Oncology, Inc. Receives FDA Fast Track Designation for TAS-102 as a Potential Treatment for Refractory Metastatic Colorectal Cancer 2Taiho Oncology, Inc. Receives FDA Fast Track Designation for TAS-102 as a Potential Treatment for Refractory Metastatic Colorectal Cancer 3Taiho Oncology, Inc. Receives FDA Fast Track Designation for TAS-102 as a Potential Treatment for Refractory Metastatic Colorectal Cancer 4The Hereditary Neuropathy Foundation and BioPontis Alliance for Rare Disease Partner to Develop Treatments for Charcot-Marie-Tooth 2The Hereditary Neuropathy Foundation and BioPontis Alliance for Rare Disease Partner to Develop Treatments for Charcot-Marie-Tooth 3
...  Cardinal Health, Detroit Medical Center (DMC) and Henry Ford ... to spur urban renewal and bring jobs to the ... ) As part of the economic recovery ... agreements with Cardinal Health, enabling the company to relocate ...
... 2012 Fluke Biomedical announced today the new ProSim ... test tool on the market to achieve the RoHS ... Hazardous Substances , RoHS regulations are designed to limit ... and to people. The RoHS E label certifies the new ...
Cached Medicine Technology:Cardinal Health, Detroit Medical Center, Henry Ford Health System Announce Unique Collaboration To Promote Urban Renewal 2Cardinal Health, Detroit Medical Center, Henry Ford Health System Announce Unique Collaboration To Promote Urban Renewal 3Cardinal Health, Detroit Medical Center, Henry Ford Health System Announce Unique Collaboration To Promote Urban Renewal 4Fluke Biomedical device first to achieve environmentally-friendly label 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: