Navigation Links
Scripps Research scientists devise powerful new method for finding therapeutic antibodies
Date:9/11/2012

no significant EPO-mimicking effect. Further tests showed that the source of the EPO-mimicking effect in the test cells was an antibody that does not occur naturally.

An antibody of the type used in the study has a Y-shaped structure, normally with two identical binding arms. But the presence of multiple antibody genes within some of Zhang's test cells meant that, in a few cases, antibodies assembled themselves with two different binding arms. One of these "bispecific" antibodies turned out to bind to the EPO receptor which has two binding sites in a way that very accurately mimics the binding of a natural EPO molecule. "It turned out to be 100 percent as potent as authentic EPO in further tests," Zhang said.

The serendipitous finding represents another major innovation, for, in principle, it extends the medical and scientific antibody repertoire from the 100 billion or so known variants of same-armed antibodies to an astronomically higher number of bispecific variants. Experiments to test such variants will be limited by the maximum number of usable cells in cultures, but that number is still very high, on the order of 10 million. "That allows for a lot of unique binding events," said Lerner. "You probably can get almost anything that way."

Lerner emphasizes that this new antibody-engineering/discovery technique can be used not just against known targets such as the EPO receptor, but also against cellular functions involving targets that have not yet been found. "The real power of this technique is its ability to help us discover the unknown," he said.


'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Clinical trials start for stroke drug developed by Scripps Research, USC, and ZZ Biotech
2. Scripps Florida scientists awarded nearly $1.5 million to develop new approaches to treat cancer
3. Scripps Research scientists show how memory B cells stay in class to fight different infections
4. Researchers improve gene therapy technique for children with immune disorder
5. Hospital for Special Surgery investigators receive National Football League grant for PRP research
6. Obesity research wins Fernström Prize
7. Moffitt researchers say race affect likelihood of finding suitable stem cell donor
8. Researchers closer to understanding actions of cells involved in atherosclerosis
9. Metabolic engineer synthesizes key breast milk ingredient, makes research possible
10. Case Western Reserve researchers create short-term memories in-vitro
11. Researchers find first evidence for a genetic cause for Barretts esophagus
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research scientists devise powerful new method for finding therapeutic antibodies
(Date:10/31/2014)... In the first study of its kind, Rice University ... circuits that cause cancer cells to become metastatic. The ... allows cancer cells to both migrate and form new ... to new drugs that interfere with the genetic switches ... cells and circulating tumor cells -- two of the ...
(Date:10/31/2014)... Daily Gossip writes in its Xtreme Fat Loss ... fastest fat loss program ever developed. It promises to provide ... There is no wonder after all that this has become ... new nutrition and workout fat loss program was created by ... According to the author of this fat loss system, the ...
(Date:10/31/2014)... (PRWEB) October 31, 2014 With all ... one Midwest optometrist feels they may overlook one critical ... affect areas like concentration, school performance and even behavior. ... too brief to identify progressive vision problems, and to ... Mo., announces a new initiative: The Awesome Eyes Student ...
(Date:10/31/2014)... 2014 (HealthDay News) -- Sleep apnea may make it hard ... parked your car or left your house keys, a small ... apnea showed that this ability -- called spatial memory -- ... sleep, even when other stages of sleep weren,t affected. REM ... typically occur. "We,ve shown for the first time that ...
(Date:10/31/2014)... of four older Americans say that either they or ... treatment, according to the latest issue of The Gerontological ... ( PP&AR ), which goes on to show ... fail to honor patients, end-of-life health care wishes. , ... Issues and Options ," features 12 articles that present ...
Breaking Medicine News(10 mins):Health News:Decoding the emergence of metastatic cancer stem cells 2Health News:Decoding the emergence of metastatic cancer stem cells 3Health News:Xtreme Fat Loss Diet Review Reveals How to Transform Your Body in 25 Days 2Health News:New School Vision Initiative Announced by Dr. Rosenak’s Optical Options; Program Aims to Help Recognize Unseen Vision Problems That Impact School Success 2Health News:New School Vision Initiative Announced by Dr. Rosenak’s Optical Options; Program Aims to Help Recognize Unseen Vision Problems That Impact School Success 3Health News:Sleep Apnea May Steal Some of Your Memory: Study 2Health News:Advance directives can benefit patients, families, and health care system 2
... ... protective equipment, bad assumptions are hazardous and can result in injury -- or ... assumptions are widespread -- endangering both the effectiveness of occupational Hearing Conservation ... paper from Howard Leight, " Bad Assumptions about Hearing Protection ...
... , ... Dec. 1 Ovid, part of Wolters Kluwer Health and a ... information for the medical, scientific and academic markets, will be showcasing ... and the implementation of a new psychology lexicon, based on the ...
... , WASHINGTON, Dec. 1 The following is being ... Kerry, Ranking Member Lugar, and Members of the Committee. , ... serve as Administrator of the United States Agency for International ... the Agency. , Secretary of State Clinton has expressed ...
... The Patient Safety Authority Encourages Older Persons and Healthcare ... Upon Authority Data , HARRISBURG, Pa., Dec. 1 ... those 65 and older, including residents in nursing homes, according ... December Patient Safety Advisory . , According to the ...
... 30 November 2009. Performing surgical operations without leaving ... become a reality. This is demonstrated by the recent ... Surgery), an innovative surgical approach that allows surgical access ... advantageous for the patient: lack of scars, shorter hospital ...
... age are more likely to engage in risky health behaviors ... aging process may act as a disincentive to behave ,sensibly, ... in anticipation of ,miserable, old age. These findings 1 ... Queen,s University Belfast, Northern Ireland, are published online in Springer,s ...
Cached Medicine News:Health News:New White Paper Details Six Common Bad Assumptions About Hearing Protection 2Health News:New White Paper Details Six Common Bad Assumptions About Hearing Protection 3Health News:Ovid Highlights the Latest Productivity Workflow Enhancements to Ovid Universal Search(TM) and its New Psychology Lexicon at London's Online Information 2009 Conference 2Health News:Ovid Highlights the Latest Productivity Workflow Enhancements to Ovid Universal Search(TM) and its New Psychology Lexicon at London's Online Information 2009 Conference 3Health News:Testimony Before the Senate Committee on Foreign Relations Administrator Designate Dr. Rajiv Shah December 1, 2009 2Health News:Testimony Before the Senate Committee on Foreign Relations Administrator Designate Dr. Rajiv Shah December 1, 2009 3Health News:Testimony Before the Senate Committee on Foreign Relations Administrator Designate Dr. Rajiv Shah December 1, 2009 4Health News:Testimony Before the Senate Committee on Foreign Relations Administrator Designate Dr. Rajiv Shah December 1, 2009 5Health News:Testimony Before the Senate Committee on Foreign Relations Administrator Designate Dr. Rajiv Shah December 1, 2009 6Health News:Testimony Before the Senate Committee on Foreign Relations Administrator Designate Dr. Rajiv Shah December 1, 2009 7Health News:Testimony Before the Senate Committee on Foreign Relations Administrator Designate Dr. Rajiv Shah December 1, 2009 8Health News:Testimony Before the Senate Committee on Foreign Relations Administrator Designate Dr. Rajiv Shah December 1, 2009 9Health News:Ninety Percent of All Vaccine Preventable Deaths Occur in Those 65 and Older According to Highlighted Studies in the December Patient Safety Advisory 2Health News:Ninety Percent of All Vaccine Preventable Deaths Occur in Those 65 and Older According to Highlighted Studies in the December Patient Safety Advisory 3Health News:Ninety Percent of All Vaccine Preventable Deaths Occur in Those 65 and Older According to Highlighted Studies in the December Patient Safety Advisory 4Health News:Ninety Percent of All Vaccine Preventable Deaths Occur in Those 65 and Older According to Highlighted Studies in the December Patient Safety Advisory 5Health News:Hospital Clinic Barcelona and Massachusetts General Hospital extract rectal mass through anus 2Health News:Hospital Clinic Barcelona and Massachusetts General Hospital extract rectal mass through anus 3Health News:Binge drinking youths find getting old a drag 2
(Date:10/30/2014)... Oct. 30, 2014 /CNW/ - Atlantic Canadians will save ... between Canada,s provinces and territories ... President of the Canadian Generic Pharmaceutical Association (CGPA), said ... while speaking at the Atlantic Summit on Healthcare and ... which is being hosted by the Public Policy Forum ...
(Date:10/30/2014)... 30, 2014 WuXi PharmaTech (Cayman) Inc. (NYSE: ... technology platform company serving the pharmaceutical, biotechnology, and medical ... and the United States , ... the Tel Aviv area of ... WuXi,s broad platform of integrated R&D services to local ...
(Date:10/30/2014)... , Oct. 30, 2014   ViaDerma, Inc. ... to bringing new products to market, has recently ... TetraStem. TetraStem is a topical liquid tetracycline-based antibiotic ... that can convert oral medication active ingredients into ... a first aid antibiotic to help prevent skin ...
Breaking Medicine Technology:Atlantic Canadians to Save $560-Million Through Unprecedented Three-Year Pan-Canadian Agreement on Generic Prescription Medicines 2Atlantic Canadians to Save $560-Million Through Unprecedented Three-Year Pan-Canadian Agreement on Generic Prescription Medicines 3WuXi AppTec Launches Representative Office in Israel, Forms Strategic Collaboration with Pontifax 2ViaDerma, Inc. Lead Product TetraStem Shown Effective in Fighting Staph Infections including MRSA 2ViaDerma, Inc. Lead Product TetraStem Shown Effective in Fighting Staph Infections including MRSA 3
... K-V Pharmaceutical Company (NYSE:  KVa/KVb) announced today that it ... Administration ("FDA") of the successful completion of an inspection ... first product to market.  Under the Company,s Consent Decree, ... and facilities are expected to be required before K-V ...
... Inc. Promote PurCotton(R) Brand in Shenzhen -- SHENZHEN, China, Sept. 10 /PRNewswire-Asia/ -- ... ... --> ... = ,; var first_result; // Results are keyed by longUrl, so we need to grab the first ...
Cached Medicine Technology:K-V Pharmaceutical Company Announces Completion of U.S. Food and Drug Administration Inspection and Approval to Return its First Product to Market 2K-V Pharmaceutical Company Announces Completion of U.S. Food and Drug Administration Inspection and Approval to Return its First Product to Market 3K-V Pharmaceutical Company Announces Completion of U.S. Food and Drug Administration Inspection and Approval to Return its First Product to Market 4K-V Pharmaceutical Company Announces Completion of U.S. Food and Drug Administration Inspection and Approval to Return its First Product to Market 5K-V Pharmaceutical Company Announces Completion of U.S. Food and Drug Administration Inspection and Approval to Return its First Product to Market 6K-V Pharmaceutical Company Announces Completion of U.S. Food and Drug Administration Inspection and Approval to Return its First Product to Market 7K-V Pharmaceutical Company Announces Completion of U.S. Food and Drug Administration Inspection and Approval to Return its First Product to Market 8Winner Medical and U.S. Cotton Inc. Promote PurCotton(R) Brand in Shenzhen 2Winner Medical and U.S. Cotton Inc. Promote PurCotton(R) Brand in Shenzhen 3Winner Medical and U.S. Cotton Inc. Promote PurCotton(R) Brand in Shenzhen 4Winner Medical and U.S. Cotton Inc. Promote PurCotton(R) Brand in Shenzhen 5Winner Medical and U.S. Cotton Inc. Promote PurCotton(R) Brand in Shenzhen 6Winner Medical and U.S. Cotton Inc. Promote PurCotton(R) Brand in Shenzhen 7Winner Medical and U.S. Cotton Inc. Promote PurCotton(R) Brand in Shenzhen 8
... Rapid Plasma Reagin ... rapid detection and quantitative ... serum or plasma. Uses ... to detect reagin. Kits ...
Latex agglutination slide test for the qualitative and semi-qualitative detection of antinuclear antibodies to aid in the diagnosis of systemic lupus erthyematosus....
... Rapid Plasma Reagin card ... detection and quantitative determination ... or plasma. Uses carbon ... detect reagin. Kits include ...
Test for the quantitative determination of antideoxyribonuclease-B (ADNase-B) in serum....
Medicine Products: