Navigation Links
Scripps Research scientist receives $1 million research grant from Novo Nordisk
Date:11/8/2011

JUPITER, FL, November 8, 2011 Andrew Butler, an associate professor in The Scripps Research Institute's Department of Metabolism and Aging, has been awarded one million dollars in funding over the next two years to further his research into a novel protein with the potential to improve the understanding and future treatment of diabetes.

The award is notable in that it comes not from the US National Institutes of Health but from Novo Nordisk, an international healthcare company based in Denmark recognized as a world-leader in diabetes treatment.

The Novo Nordisk Diabetes Innovation Award Program was launched in 2011 to help scientists substantiate early research efforts that could result in new treatment options for diabetes and obesity.

Butler's two-year research project, entitled the "Investigation of a Novel Peptide Hormone in Diabetes Treatment," was selected from more than 80 submitted proposals from US and Canadian research institutions.

The research involves a peptide hormone secreted by the liver called adropin. Animal models have shown that peptide hormones play an important role in regulating glucose levels and fatty acid metabolism and that irregular function of these hormones can have a direct effect on an individual's risk of developing obesity and/or diabetes.

"We were studying animal models of insulin resistance as precursor to type 2 diabetes, when we came across adropin," Butler said. "We found it provocative that this particular peptide hormone was distributed in the brain, liver, and pancreasthree tissues that are of great interest to those of us in the diabetes research field."

Butler noted that adropin seems to play a role in maintaining normal insulin sensitivitywhereby only a relatively small amount of insulin is needed to maintain regular blood glucose levels. In type 2 diabetes, insulin sensitivity is often blunted, which means that the normal amounts of insulin produced by the body are no longer as effective in lowering blood glucose levels.

"What has not been established are the mechanisms and sites of action that effect glucose homeostasis [equilibrium]," he said. "So that's what we're going to spend the next two years finding out with the help of this research grant from Novo Nordisk."

The research will also explore adropin's potential role as a protein-based therapy for treating type 2 diabetes, a chronic disease that affects over 300 million people worldwide, according to the World Health Organization. "Clearly, there is an urgent need to identify new and more effective drugs for treating diabetes," Butler said. "Studying how adropin works in this regard could eventually contribute to this effort."


'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Related medicine news :

1. Scripps Florida scientist awarded $2.2 million grant to study hepatitis C
2. Scripps research scientist wins $3.6 million NIH Method to Extend Research in Time award to study alcoholism in Native Americans
3. Scripps Health and Sanford-Burnham to collaborate to advance new cancer treatments
4. Scripps Research scientists reveal how white blood cell promotes growth and spread of cancer
5. Scripps Research scientists define cellular pathway essential to removing damaged mitochondria
6. Scripps Translational Science Institute joins Jackson Laboratory tumor consortium
7. Scripps Research scientists show how shifts in temperature prime immune response
8. CIRM awards Scripps Research Institute scientists $3.5 million
9. Scripps Research wins more than $2 million to study prostate cancer
10. New lupus drug results from Scripps Research technology
11. Scripps Research and MIT scientists discover class of potent anti-cancer compounds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research scientist receives $1 million research grant from Novo Nordisk
(Date:2/12/2016)... Washington, DC (PRWEB) , ... ... ... the Siemens Foundation today announced a new initiative—the Siemens Foundation-PATH Ingenuity Fellowships—to ... settings. The partnership will recruit top students from U.S. universities who will ...
(Date:2/12/2016)... ... February 12, 2016 , ... Fixed Dose ... – 3:00 p.m. EST, http://www.fdanews.com/fixeddosecombination , Fixed dose ... products, garnering increased attention from all stakeholders in the development of new chemical ...
(Date:2/12/2016)... ... 12, 2016 , ... Coco Libre, the maker of coconut water beverages with ... Style Lounge Event. Coco Libre will offer musicians and celebrities the company’s signature Organic ... The invitation-only gifting suite, held this year at the W Hollywood Hotel, has become ...
(Date:2/12/2016)... FL (PRWEB) , ... February 12, 2016 , ... ... as a Service (WaaS), today announced the integration of Clarity Intelligence Platform (CIP) ... channel partners to offer real-time business intelligence (BI) to their small and medium ...
(Date:2/12/2016)... ... February 12, 2016 , ... AssureVest Insurance Group, a ... initiating a charity drive that will raise funds earmarked to purchase computers and software ... Elementary School. , “My school is in a low-income area and has more than ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... 12, 2016   National Community Pharmacists Association ... issued the following statement today in response to the ... the Centers for Medicare & Medicaid Services (CMS) and ... advocates and others: patient advocacy organizations ... reviewing the full CMS analysis. Our initial reaction is ...
(Date:2/12/2016)... 12, 2016 /PRNewswire/ - Demers Ambulances announces its first delivery in ... Okaloosa County Emergency Medical Services (EMS) consisting ... one LT2 van. Quality Emergency Vehicles in Lecanto, ... the sale.  This is the latest in Demers, ongoing expansion ... President at Demers. --> Benoit LaFortune , Executive ...
(Date:2/12/2016)... , Feb. 12, 2016  Memorial Hermann Health ... Dwight Howard to bring a one-of-a-kind experience ... . Using cutting-edge technologies such as 360-degree video and ... both virtually, then literally – giving the patients and ... and it was all caught on video . ...
Breaking Medicine Technology: