Navigation Links
Scripps Research cancer biology department awarded more than $8 million in new research grants
Date:4/22/2009

recapitulate these through pharmaceutical approaches for thymus regeneration therapy.

  • Cleveland received a five-year grant (approximately $2.1 million) from NIH/NCI to study the regulation and role of the enzyme ornithine decarboxylase (Odc). This enzyme plays key roles in cancer and is directly regulated by cancer-causing Myc oncoproteins and also by mutated Ras oncogenes, which together are activated in more than 80 percent of all human tumors. This new study focuses on defining the various roles of Odc in regulating the development of lymphoma, lung, and breast cancer, and determining how Odc regulates the proliferative response induced by oncogenes. Cleveland hopes that these studies will reveal new targets for cancer prevention and treatment.

  • Jun-Li Luo, Ph.D., received a three-year grant (approximately $430,000) from the U.S. Department of Defense to study the interaction between cancer stem cells and immune/inflammatory cells during the growth and progression of prostate cancer. In a study published in a 2004 issue of the journal Cancer Cell, Luo and colleagues developed a novel strategy to fight the disease, turning the body's inflammatory response, which under normal circumstances encourages tumor growth, into a cancer-killing machine. In 2007 Luo published an article in Nature that established links between the nuclear factor NF-κB and the spread of prostate cancer in animal models.

In addition to these funds, investigators in the Department of Cancer Biology were awarded a four-year grant (approximately $1.6 million) from NIH's National Institute of General Medical Science to study the structural dynamics of vinculin, a cytoskeletal protein that plays key roles in controlling cell-cell and cell-matrix adhesion complexes, as well as cell migration and cancer metastasis.


'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scripps research scientists model 3D structures of proteins that control human clock
2. Scripps Health Selects Allscripts for Electronic Health Record
3. Scripps research scientists engineer new type of vaccination that provides instant immunity
4. Scripps research scientists develop general-purpose method for detecting trace chemicals
5. Team led by Scripps Scientists increases understanding of two types of blindness
6. KRAUSE, KALFAYAN, BENINK & SLAVENS, LLP, Announces Filing a Class Action Lawsuit Against Scripps Health, et al.
7. Scripps Health Enhances Employee Wellness Program With Home Testing Solutions From BioIQ
8. Scripps Research Institute and IAVI launch worlds first dedicated HIV neutralizing antibody center
9. Scripps Translational Science Institute Contributes to Discovery of Predisposition Gene for Childhood Cancer
10. Scripps research team unravels new cellular repair mechanism
11. Scripps Research scientists find seizure drug reverses cellular effects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)... Homeowners that are wondering how they can tell ... more. Clean Crawls gives 5 signs of poor ... it comes to insulation in their recently released article. ... Clean Crawls, can cause problems throughout your entire home. ... deteriorated, become damp, or been infested with pests should ...
(Date:10/25/2014)... 2014 Limbkeepers® announced today that they ... with Ed Begley Jr, airing 1st QTR 2015 via ... this episode, Innovations will focus on Limbkeepers® non compression ... thinning skin on arms, hands, and legs from abrasion, ... versatile products, which help reduce injuries, allow for continued ...
(Date:10/25/2014)... News) -- Not getting the right amount of sleep ... study suggests. Those who sleep less or more ... may be more prone to developing the chronic condition, ... study authors concluded that duration and quality of sleep ... inflammatory bowel diseases. "Both short and long durations ...
(Date:10/25/2014)... Oct. 23, 2014 (HealthDay News) -- Current osteoporosis ... younger postmenopausal women at risk for osteoporosis-related fractures, ... to prevent fractures, we need tools that help ... injuries so that we can target these at-risk ... Crandall, professor of medicine in the division of ...
(Date:10/22/2014)... October 22, 2014 At a time ... among parents and athletes at all levels, the ... change the current discussion where two powerful messages are ... therapies that result in full recoveries every day. , ... based in fact and research, UPMC and the Concussion ...
Breaking Medicine News(10 mins):Health News:5 Signs Indicating That Insulation Needs Replacing as Told By Clean Crawls in Recent Article 2Health News:Upcoming Episode of Innovations with Ed Begley, Jr. to Feature Limbkeepers® 2Health News:Sleep Duration Linked to Ulcerative Colitis Risk in Study 2Health News:Osteoporosis Screening Guidelines May Miss Younger Women at Risk 2Health News:University of Pittsburgh Medical Center Launches Initiative to Emphasize Concussions Are Treatable 2Health News:University of Pittsburgh Medical Center Launches Initiative to Emphasize Concussions Are Treatable 3Health News:University of Pittsburgh Medical Center Launches Initiative to Emphasize Concussions Are Treatable 4
... is used widely for colonoscopic exploration and colonic ... is the osmotic laxative most commonly used for ... induce severe hyperphosphatemia and hypocalcemia due to excessive ... of deaths and irreversible dialysis-requiring renal insufficiency. However, ...
... mellitus is one of the most common chronic disease ... is over 10% in Taiwan. Gastroparesis is reported in ... (SMA) syndrome is an uncommon disease resulting compression of ... mesenteric artery. However, SMA syndrome can cause the same ...
... ... begun the new year by expanding their existing Green Bay, WI presence with the ... ... growing technology company representing both businesses and residents has joined forces with Buildmyownsite, Inc., ...
... emergency department, federal report shows , THURSDAY, Jan. 14 ... million motor vehicle crash victims who had injuries ranging ... a new government study finds. , About 85 percent ... 321,000 were admitted or transferred to another acute care ...
... ... mental tasks is highly predictive of crash risk and a small amount of ... to research presented this week at the 2010 annual meeting of the ... the age wave of 70 million baby boomers begins to join the ranks ...
... , ... Dentist Honored in 2010 Edition of Who’s Who as dentist of the year. ... New York, NY (Vocus) January ... convenience, has been honored by the Presidential Who’s Who organization as dentist of the year. ...
Cached Medicine News:Health News:Infinity Technology, Inc. Acquires Build My Own Site, Inc. 2Health News:Brain Fitness Predicts Crash Risk 2Health News:Brain Fitness Predicts Crash Risk 3Health News:Brain Fitness Predicts Crash Risk 4Health News:Dr. Jan Linhart to Appear in Presidential Who's Who Among Business and Professional Achievers 2
(Date:10/22/2014)... 2014 Oramed Pharmaceuticals Inc. ... pharmaceutical company focused on the development of oral ... results from its Phase IIa clinical trial of ... treat type 1 diabetes. The trial was conducted in ... a U.S. Food and Drug Administration (FDA) Investigational ...
(Date:10/22/2014)... Oct. 21, 2014 Influenza will affect as many ... the United States as high as ... to spread is from person to person in respiratory droplets ... serve way of death, but kills much fewer people each ... done by human fluids including sweat, saliva, blood and other ...
(Date:10/22/2014)... Calif. , Oct. 22, 2014 WHEN: ... EDTLOCATION: Online, complimentary registration available at: ... Leader Archana Vidyasekar and Visionary Innovation Research ... WiFi-like wireless electricity, self-assembling materials, nanobots and ... technologies which will transform our lives in ...
Breaking Medicine Technology:Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 2Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 3Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 4WholeHealth Products is proud to be releasing its Influenza A and B combo test, on the heels of the announcing of its phase 2 completion of the Rapid Ebola Test 2Futuristic Technologies That Will Transform Our World Beyond 2030 2Futuristic Technologies That Will Transform Our World Beyond 2030 3Futuristic Technologies That Will Transform Our World Beyond 2030 4
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: