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Scripps Research and MIT scientists discover class of potent anti-cancer compounds
Date:3/7/2011

gy or Alzheimer's disease drugs.

"Already several labs from both academia and industry have contacted us about collaborating on PME-1 research," said Cravatt. "So our findings here are scientifically interesting, and I think could, one day, be valuable clinically. But it's important to emphasize that we wouldn't have these findings at all, were it not for the NIH Molecular Libraries Program and its compound library. Both on the screening side and the chemistry side, the NIH enabled us academics to bring technologies to the table unlikely to be found in a traditional 'pharma' setting. Our discoveries thus stand as a fine example of the value of public screening for creating novel, in vivo-active pharmacological probes for challenging protein targets."

The paper's other co-authors were Justin T. Mohr and Jacob M. Berlin of the Fu laboratory at MIT; Timothy P. Spicer, Virneliz Fernandez-Vega, Peter Chase, Peter S. Hodder, and Stephan C. Schrer of the Scripps Molecular Screening Center in Jupiter, Florida; and Anna E. Speers, Chu Wang, Daniel K. Nomura and Hugh Rosen of the Scripps Research campus in La Jolla, California.

The activities described in this release are funded through the National Institutes of Health (MH084512, CA132630, and GM57034).


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Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

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