Navigation Links
Scripps Research and MIT scientists discover class of potent anti-cancer compounds
Date:3/7/2011

LA JOLLA, CA, AND JUPITER, FL March 7, 2011 Embargoed by the journal PNAS until March 7, 2011, 3 PM, Eastern time Working as part of a public program to screen compounds to find potential medicines and other biologically useful molecules, scientists from The Scripps Research Institute and Massachusetts Institute of Technology (MIT) have discovered an extremely potent class of potential anti-cancer and anti-neurodegenerative disorder compounds. The scientists hope their findings will one day lead to new therapies for cancer and Alzheimer's disease patients.

The researchscheduled for publication in the journal Proceedings of the National Academy of Sciences (PNAS) the week of March 7, 2011was led by Benjamin F. Cravatt III, professor and chair of the Department of Chemical Physiology at Scripps Research and a member of its Skaggs Institute for Chemical Biology, and MIT chemistry professor Gregory Fu.

"It was immediately clear that a single class of compounds stood out," said Daniel Bachovchin, a graduate student in the Cravatt lab and the study's first author. "The fact that these compounds work so potently and selectively in cancer cells and mice, right off the screening deck and before we'd done any medicinal chemistry, is very encouraging and also very unusual."

Browsing in the Public Library

The National Institutes of Health (NIH) Common Fund Molecular Libraries Program currently funds nine screening and medicinal chemistry-related centers at academic institutions around the United States to enable scientists to find biologically interesting molecules, independently of commercial labs (http://mli.nih.gov/mli/mlpcn/mlpcn-probe-production-centers/). In these centers, academic scientists can test thousands of compounds at once through high-throughput screens against various biological targets to uncover "proof-of-concept" molecules useful in studying human health and in developing new treatments for
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Scripps Health Begins Pioneering Study of Human Tumor Sequencing in Cancer Patients
2. Top Scientists Explore the Origin of Life in Annual Lasker Lecture at Scripps Research Institute Florida Campus
3. Scripps Blood & Marrow Transplant Program Celebrates 30th Anniversary of Providing Life-Saving Care
4. Scripps Memorial Hospital La Jolla First in San Diego to Achieve Magnet Nursing Re-designation
5. Scripps Announces Plans for Region's First Proton Therapy Center; $185 Million Facility to Offer Advanced Care to Cancer Patients
6. Scripps Research scientists share $2 million in Florida state research grants
7. Scripps Center for Executive Health Now Offers Genetic Testing
8. Scripps Research scientists uncover previously unknown natural mechanism that controls cocaine use
9. NIH awards Scripps Florida scientists $2.3 Million to develop drug addiction treatments
10. Scripps Research scientists solve long-standing mystery of protein quality control mechanism
11. Scripps and Trius team up to develop new antibiotics with US Department of Defense grant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Juvent Sports ( http://www.juventsports.com ) and David ... Show to bestow a Juvent Sports Achievement award upon ... McKitrick. The award commemorated and congratulated McKitrick for her ... won her first amateur tournament in 1979 and most ...
(Date:1/22/2015)... Oceanside,CA (PRWEB) January 22, 2015 For over 20 ... the Oceanside and Vista area has treated just about ... other personal injury circumstances. And for those same twenty-plus years, ... victims of all those injuries with the best possible doctor. ...
(Date:1/22/2015)... 2015 Yesterday, Senator Holly Mitchell ... Kristin Olsen (R-Modesto) were honored by the California ... biotechnology, biomedical science, medical device and pharmaceutical innovation ... the “2014 Life Sciences Champion” award from CHI ...
(Date:1/22/2015)... Payday lending practices in four southern ... financial distress to the states that permit them, according ... Center on Race and Wealth. , While they generate ... loans at the same time substantially depress economic activity, ...
(Date:1/22/2015)... a new blog post presenting a list of vehicles that cannot ... Some types of vehicles cannot be covered under an ordinary auto ... see if their vehicle qualifies for auto insurance coverage. , ... that cannot be covered by a plan. Clients have little options ...
Breaking Medicine News(10 mins):Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2
... January 26, 2009 ROANOKE, Va., Jan. 21 ... - www.stuttering.org ), a leading center for ... successful trials using Apple,s iPhone as a stuttering ... fluency skills from the clinical setting into real-life ...
... 21 , Fourth Quarter Highlights, -- ... -- Record income before income taxes of $5.1 million, up 14 percent., ... $0.25 per diluted share., Fiscal 2008 Highlights, ... -- Record income before income taxes of $16.4 million, up ...
... and Triaminic(R) send Sick Day Guidelines home to help guide ... children get six to 10 colds every year and some ... Jan. 21 Parents just know when their children aren,t ... and sniffles warrant keeping them home from school. In fact, ...
... , Who: PlanetHospital(TM), the leader and pioneer ... tourism., What: A highly informative meet and greet ... singles, and infertile couples in Los Angeles and New York, ... Allahbadia. Admission is FREE., ...
... first quarter of 2009, Auerbach International is offering discounted rates on ... global marketing agencies in the United States, Auerbach International offers an ... , ... (PRWEB) January 21, 2009 -- Auerbach International Inc., ...
... "All About Me" Children,s Health Journal has just come out. In it,s ... their childrens, immunizations and developmental progress. It is both a keepsake, and ... been using it since its inception. A diaper bag must. , ... ...
Cached Medicine News:Health News:Photos: Apple's iPhone Finds New Use in Treating Stuttering at Hollins Communications Research Institute 2Health News:Photos: Apple's iPhone Finds New Use in Treating Stuttering at Hollins Communications Research Institute 3Health News:Somanetics Reports Record Net Revenues and Income Before Income Taxes for Fourth Quarter and Fiscal 2008 2Health News:Somanetics Reports Record Net Revenues and Income Before Income Taxes for Fourth Quarter and Fiscal 2008 3Health News:Somanetics Reports Record Net Revenues and Income Before Income Taxes for Fourth Quarter and Fiscal 2008 4Health News:Somanetics Reports Record Net Revenues and Income Before Income Taxes for Fourth Quarter and Fiscal 2008 5Health News:Somanetics Reports Record Net Revenues and Income Before Income Taxes for Fourth Quarter and Fiscal 2008 6Health News:Somanetics Reports Record Net Revenues and Income Before Income Taxes for Fourth Quarter and Fiscal 2008 7Health News:Somanetics Reports Record Net Revenues and Income Before Income Taxes for Fourth Quarter and Fiscal 2008 8Health News:Somanetics Reports Record Net Revenues and Income Before Income Taxes for Fourth Quarter and Fiscal 2008 9Health News:Somanetics Reports Record Net Revenues and Income Before Income Taxes for Fourth Quarter and Fiscal 2008 10Health News:Somanetics Reports Record Net Revenues and Income Before Income Taxes for Fourth Quarter and Fiscal 2008 11Health News:New Sick Day Guidelines Help Parents Make the Right Call This Cold Season 2Health News:New Sick Day Guidelines Help Parents Make the Right Call This Cold Season 3Health News:New Sick Day Guidelines Help Parents Make the Right Call This Cold Season 4Health News:PlanetHospital(TM) Helps Gay Couples Discover Having Children Via Surrogacy in India 2Health News:PlanetHospital(TM) Helps Gay Couples Discover Having Children Via Surrogacy in India 3Health News:Spanish On-Sale: Auerbach International Offers Discounted Rates for Spanish Translations 2Health News:Spanish On-Sale: Auerbach International Offers Discounted Rates for Spanish Translations 3Health News:Pocket Reference Journals Releases Latest Edition of "All About Me" Leading Children's Immunization Journal for New Moms 2Health News:Pocket Reference Journals Releases Latest Edition of "All About Me" Leading Children's Immunization Journal for New Moms 3
(Date:1/23/2015)... Jan. 23, 2015  Today the U.S. Food and Drug ... the prevention of serogroup B meningococcal disease ... vaccine Trumenba®, which received FDA approval in October, represent ... disease. "I have heard over and ...
(Date:1/23/2015)... 23, 2015 Research and Markets ( http://www.researchandmarkets.com/research/5dh22x/urinary_catheters ... Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and ... Size, Share, Growth, Trends and Forecast 2014 - 2020" ... At present, the global market for urinary catheters is ...
(Date:1/23/2015)... BETHESDA, Md. , Jan. 23, 2015  Northwest Biotherapeutics, Inc. ... developing DCVax® personalized immune therapies for operable and inoperable solid ... will present at the 7 th Annual Phacilitate Immunotherapy ... NW Bio,s presentation at Phacilitate will take place on January ...
Breaking Medicine Technology:The National Meningitis Association (NMA) Applauds FDA Approval of Second Vaccine To Protect Against Serogroup B Meningococcal Disease 2Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 2NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 3
... 2011 ChromaDex® Corp. (OTCBB: CDXC) today announced ... ChromaDex® the exclusive rights to a joint patent ... the method of inducing UDP-glucuronosyltransferase (UGT) activity using ... found in blueberries and demonstrated to have multiple ...
... Sept. 8, 2011 Abaxis, Inc. (NasdaqGS: ABAX), a ... today that Clint Serverson, chief executive officer,  will present ... Tuesday, September 13, 2011 at 10:20 a.m. ET at ... AbaxisAbaxis develops, manufactures, markets and sells portable blood analysis ...
Cached Medicine Technology:ChromaDex®'s Novel Ingredient pTeroPure® to be Studied as Potential Treatment for Fighting Skin Cancers 2ChromaDex®'s Novel Ingredient pTeroPure® to be Studied as Potential Treatment for Fighting Skin Cancers 3Abaxis to Present at 2011 Morgan Stanley Global Healthcare Unplugged Conference 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: