Navigation Links
Scripps Research Institute study points to potential new therapies for cancer and other diseases
Date:11/27/2012

LA JOLLA, CA November 27, 2012 Researchers at The Scripps Research Institute (TRSI) are fueling the future of cancer treatment by improving a powerful tool in disease defense: the body's immune system. By revealing a novel but widespread cell signaling process, the scientists may have found a way to manipulate an important component of the immune system into more effectively fighting disease.

The study, recently published online ahead of print by the journal Blood, shows that disabling a particular enzyme, called ItpkB, in mice improves the function of a type of immune cell called Natural Killer cells.

"This is an exciting finding because it could possibly lead to the development of drugs that improve Natural Killer cell function," said TSRI Associate Professor Karsten Sauer, PhD, who led the study. "Natural Killer cells have gained clinical interest as innovative biological therapeutics for certain cancers and also in certain infectious diseases."

The Body's 'SWAT Team'

Natural Killer cells patrol the body and detect characteristic alterations on the surface of cancer cells or virus-infected cells. Through a complicated and little understood signaling machinerya domino effect of molecular reactions in a cell that ultimately produces a certain signalNatural Killer cells then destroy such "stressed" cells.

Compared to other types of immune cells, Natural Killer cells kill these cells quickly. This makes Natural Killer cells important early responders of the immune system. Not surprisingly, researchers have explored engaging this "SWAT team" of the body therapeutically, particularly in blood cancers.

However, to date, the therapeutic efficacy of Natural Killer cells has been limited. "A key bottleneck is our limited understanding of signaling mechanisms that dampen Natural Killer cell function," Sauer said.

Sauer and colleagues' new research reveals crucial details of this puzzle.

A Way to Prime the Attack

The Sauer group had previously identified ItpkB as a key regulator of immune function. ItpkB acts primarily by producing IP4, a small molecule messenger that controls the functions of various other important signaling molecules. IP4 can improve or inhibit signaling depending on the cell type in which it is produced.

The new research showed that Natural Killer cells from mice lacking ItpkB show elevated signaling and function better than Natural Killer cells that have the enzyme. As a result, mice lacking ItpkB are more effective than mice expressing ItpkB in attacking cells that display characteristic surface changes of cancer cells.

"The enzyme ItpkB has unique features that facilitate its highly specific inhibition by small molecules," said Sauer. "Our findings suggest that such compounds could possibly be used to improve Natural Killer cell function therapeutically. If successful, this could overcome a bottleneck and engage the body's SWAT team to fight cancer."


'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Related medicine news :

1. Scripps Research scientists show how memory B cells stay in class to fight different infections
2. Scripps Florida scientists awarded nearly $1.5 million to develop new approaches to treat cancer
3. Clinical trials start for stroke drug developed by Scripps Research, USC, and ZZ Biotech
4. Scripps Research scientists devise powerful new method for finding therapeutic antibodies
5. Scripps Research Institute scientists show protein linked to hunger also implicated in alcoholism
6. Scripps Research Institute receives $20 million to shed light on HIV drug resistance
7. Scripps studies show community-based diabetes programs are key to lowered costs and improved care
8. 2 Scripps Research Institute scientists honored by American Chemical Society
9. UCLA Brain Injury Research Center gets NCAA funding for research on sports concussions
10. NIH awards $20 million over 5 years to train next generation of global health researchers
11. Researchers develop a new cell and animal model of inflammatory breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research Institute study points to potential new therapies for cancer and other diseases
(Date:5/24/2017)... ... 2017 , ... Altec Products, Inc., a leader in enterprise document ... technology conference in San Diego, CA. , At nVerge 2017, Altec will be ... and enhance their Sage ERP solutions by providing improved visibility and control to the ...
(Date:5/24/2017)... ... , ... Patients who want to receive cosmetic dentistry procedures such as Invisalign® ... for a consultation, with or without a referral. Dr. Bedich enjoys improving the appearance ... , Dr. Bedich offers a variety of cosmetic dentistry services at his practice that ...
(Date:5/24/2017)... Lake Orion, Michigan (PRWEB) , ... ... ... is a disease affecting the female reproductive tract in which the endometrial ... the pelvic structures causing inflammation and pain. Patients experiencing painful intercourse, painful ...
(Date:5/24/2017)... ... May 24, 2017 , ... Adelberg-Montalvan Pediatric ... options for its patients on Long Island, New York. , Holistic dentistry ... and is one of the biggest trends in dentistry today. , Dentist ...
(Date:5/24/2017)... (PRWEB) , ... May 24, 2017 , ... Technique, technique, ... back injury when either lifting weights for strength training and exercise or simply lifting ... Center . , “Body position is everything,” Dr. Chang says. “Improper technique in lifting ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)... 2017 Zimmer Biomet Holdings, Inc. (NYSE and ... announced it has earned a spot on Forbes, ... Company was ranked among 500 U.S. employers as well ... Equipment and Services. The annual Forbes ... independent survey of over 30,000 employees across 25 industries. ...
(Date:5/9/2017)... May 9, 2017  Oramed Pharmaceuticals Inc. (NASDAQ: ... clinical-stage pharmaceutical company focused on the development of ... Canadian Intellectual Property Office has granted Oramed a ... of Exenatide". The patent covers Oramed,s invention of ... GLP-1 is an incretin hormone that stimulates the ...
(Date:5/8/2017)... NEW YORK , May 8, 2017 ... in the transition from fee for service reimbursement. Black ... April 2017. 1.       The Market for ... 77% of physician practices with 3 or ... Compliance Technology Solutions by Q4. "Given the magnitude of ...
Breaking Medicine Technology: