Navigation Links
Scripps Research Institute receives $20 million to shed light on HIV drug resistance
Date:9/19/2012

LA JOLLA, CA, September 19, 2012 The Scripps Research Institute has received a grant totaling approximately $20 million over five years from the National Institutes of Health to research the development of drug resistance in HIV, the virus that causes AIDS.

The grant will create a new consortium, the HIV Interaction and Viral Evolution (HIVE) Center, to better understand drug resistance and lay the groundwork for developing new anti-HIV treatments.

"We're excited about the project," said Scripps Research Professor Arthur Olson, PhD, who is principal investigator of the new center. "Using HIV, we aim to develop a broad methodology to develop drugs in the context of the evolution of drug resistance. In the process, we'll pursue any new anti-HIV drug, combination, or approach we find that is robust in the face of drug resistance as a potential treatment regimen."

"This center brings together an impressive team of virologists and structural biologists to investigate the structure and function of HIV, including how it responds to the selective pressure imposed by the drugs used in AIDS therapy," said Michael Sakalian, PhD, the official who oversees the grant at the NIH National Institute of General Medical Sciences, which made the award with the National Institute of Allergy and Infectious Diseases. "Their efforts, which focus on elements of the virus that have been difficult to study, will further our understanding of host-pathogen interactions and ways to combat drug resistance."

The current effort grew out of Olson's 15 years of research on HIV protease, a viral enzyme that is a target for several anti-HIV drugs. While the laboratory had been making progress on this avenue of research, Olson realized that all three of the virus's enzymesprotease, integrase, and reverse transcriptasewere interacting as the virus mutated.

"A virus is a complex system, especially HIV, and there are all kinds of interplay between different drug targets," noted Olson. "There's a lot we don't know about how these enzymes interact with each other, other proteins, and human proteins."

To help fill in these gaps, Olson decided to propose a center to look at the evolution of resistance in the life cycle of the entire virus. He began reaching out to researchers with complementary specialties in the field of HIV research.

The result is a group of top researchers from across the country who will collaborate as part of the HIVE Center. The team includes: Edward Arnold, Ronald Levy, Roger Jones, and Joseph Marcotrigiano of Rutgers University; Alan N. Engelman of the Dana Farber Cancer Institute; Michael Parniak of the University of Pittsburgh; Mamuka Kvaratskhelia of Ohio State University; Alan Rein and Stephen Hughes of the National Cancer Institute-Frederick; and Richard K. Belew of Electronic Artifacts.

The group also includes scientists from both the Florida and California campuses of Scripps Research. On the California campus, joining the center will be David Goodsell, Bruce E. Torbett, Charles D. Stout, Vadim Cherezov, John Elder, and Valery V. Fokin. Contributing expertise from the Florida campus will be Patrick Griffin and Douglas Kotejin.

Olson notes the center will also draw on a clinical component that provides access to records and samples from active-duty military personnel receiving HIV treatment. This will enable the scientists to track changes in the evolution of the viral population under different conditions, including a change in treatment regimen.


'/>"/>
Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Related medicine news :

1. Scripps Research scientists show how memory B cells stay in class to fight different infections
2. Scripps Florida scientists awarded nearly $1.5 million to develop new approaches to treat cancer
3. Clinical trials start for stroke drug developed by Scripps Research, USC, and ZZ Biotech
4. Scripps Research scientists devise powerful new method for finding therapeutic antibodies
5. Scripps Research Institute scientists show protein linked to hunger also implicated in alcoholism
6. UCLA Brain Injury Research Center gets NCAA funding for research on sports concussions
7. NIH awards $20 million over 5 years to train next generation of global health researchers
8. Researchers develop a new cell and animal model of inflammatory breast cancer
9. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
10. Sexually abused boys at risk for more unsafe sex: UBC research
11. Researchers Find Gene Mutations That May Be a Key to Autism
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research Institute receives $20 million to shed light on HIV drug resistance
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history of ... Brink” is the creation of published author, William Nowers. Captain Nowers and his ... veteran, he spent thirty years in the Navy. Following his career as a ...
(Date:10/12/2017)... ... 12, 2017 , ... The company has developed a suite ... regulatory authorities worldwide. From Children’s to Adults 50+, every formula has been developed ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, ...
(Date:10/12/2017)... Rockville, Maryland (PRWEB) , ... October 12, 2017 ... ... a magnetic drug delivery system that we intend to develop to enable prevention ... regimens can lead to severe hearing loss, especially in pediatric patients. For cisplatin, ...
(Date:10/12/2017)... Chapel, FL (PRWEB) , ... October 12, 2017 , ... ... is holding a treadmill relay – Miles by Moonlight to raise money for the ... donating $300 or more. , Teams will work together to keep their treadmills ...
(Date:10/12/2017)... ... October 12, 2017 , ... Vohra Chief Medical ... to physician colleagues, skilled nursing facility medical directors and other clinicians at various ... Wound Care." , "At many of these conferences we get to educate other ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... Divoti USA will engrave and process all non-coated stainless ... FDA requirements, which stipulates new criteria regarding medical device manufacture and ... ID jewelry such as Medical ID Bracelets, can rest assured that ... the new FDA requirements . ... Divoti offers this dark mark fiber laser engraving process with ...
(Date:10/11/2017)... , Oct. 11, 2017  True Health, ... has amplified its effort during National Breast Cancer ... hereditary cancer risks. ... Clinical Oncology calculated that more than 10 million ... inherited mutations in BRCA1 or BRCA2 and have not ...
(Date:10/7/2017)... --  Provista, a proven leader in the supply ... power, today announced a new resource area on Provistaco.com ... is the online home for case studies, articles on ... releases, slideshows and events. ... at their fingertips, viewers can also watch short videos ...
Breaking Medicine Technology: