Navigation Links
Scripps Florida scientists uncover inflammatory circuit that triggers breast cancer
Date:2/23/2012

JUPITER, FL, February 23, 2012 Although it's widely accepted that inflammation is a critical underlying factor in a range of diseases, including the progression of cancer, little is known about its role when normal cells become tumor cells. Now, scientists from the Florida campus of The Scripps Research Institute have shed new light on exactly how the activation of a pair of inflammatory signaling pathways leads to the transformation of normal breast cells to cancer cells.

The study, led by Jun-Li Luo, an assistant professor at Scripps Florida, was published online before print by the journal Molecular Cell on February 23, 2012.

The scientists' discovery points to the activation of a self-sustaining signaling circuit that inhibits a specific RNA, a well-known tumor suppressor that helps limit the spread of cancer (metastasis). Therapies that disable this circuit and halt this miRNA repression could have the potential to treat cancer.

The Spark that Ignites Trouble

In the new study, scientists identified the specific pathways that transform breast epithelial cells into active cancer cells.

The researchers found immune/inflammatory cells ignite the transient activation of MEK/ERK and IKK/NF-kB pathways; the MEK/ERK pathway then directs a consistent activation of a signaling circuit in transformed cells. This consistent signaling circuit maintains the malignant state of the tumor cells.

Luo compares this process to starting a cara car battery starts the engine much like the transient signal activation turns on the consistent signal circuit. Once the engine is started, it no longer needs the battery.

The scientists go on to show that the initial activation of these pathways also activates IL6, a cytokine involved in a number of inflammatory and autoimmune diseases, including cancer. IL6 acts as a tumor initiator, sparking the self-sustaining circuit in normal breast cells necessar
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Scripps research scientists demonstrate effective new biopsy in a blood test to detect cancer
2. Scripps research scientists illuminate cancer cells survival strategy
3. Jeopardy! winnings spur IBM and Scripps Research Institute collaboration to fight against malaria
4. Scripps Research scientists identify new class of antimalarial compounds
5. Scripps Research scientist receives $1 million research grant from Novo Nordisk
6. Scripps Florida scientist awarded $2.2 million grant to study hepatitis C
7. Scripps research scientist wins $3.6 million NIH Method to Extend Research in Time award to study alcoholism in Native Americans
8. Scripps Health and Sanford-Burnham to collaborate to advance new cancer treatments
9. Scripps Research scientists reveal how white blood cell promotes growth and spread of cancer
10. Scripps Research scientists define cellular pathway essential to removing damaged mitochondria
11. Scripps Translational Science Institute joins Jackson Laboratory tumor consortium
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Florida scientists uncover inflammatory circuit that triggers breast cancer
(Date:8/20/2014)... Ticket Down is a reliable source ... In just a week, the U.S. Open Tennis Championship will ... event was originally founded in 1881 and features grass courts since ... to withdrawal from the event because of a wrist injury. Serena ... return to New York City with hopes of winning her sixth ...
(Date:8/20/2014)... examined patient and tumor characteristics for melanomas with ... growth) in an effort to increase earlier detection ... , Author: Sarah Shen, M.B.B.S., B.Med.Sci., of ... Background: The tumor characteristic known as mitotic ... with prognosis and survival in melanoma patients. However, ...
(Date:8/20/2014)... is now, Free content, The time to deploy ... being published early online today in Annals ... School of Public Health write that the relentless epidemiologic ... represent a public health crisis that shows no signs ... been developed in the last decade, yet the sporadic ...
(Date:8/20/2014)... Loss of brain cells that act as a "sleep ... falling and staying asleep, a new study suggests. ... and often results in nighttime confusion and wandering, according ... the Rush Memory and Aging Project, which includes nearly ... being followed until death, at which point their brains ...
(Date:8/20/2014)... NY (PRWEB) August 20, 2014 The ... firm Perkins Eastman is pleased to announce ... services in China and the surrounding ... Principal Richard Sprow AIA has relocated to ... 40-year career in healthcare planning and design and to ...
Breaking Medicine News(10 mins):Health News:2014 U.S. Open Tennis Tickets: Ticket Down Slashes Ticket Prices on All US Open Tennis Championship Sessions in New York at Arthur Ashe Stadium 2Health News:2014 U.S. Open Tennis Tickets: Ticket Down Slashes Ticket Prices on All US Open Tennis Championship Sessions in New York at Arthur Ashe Stadium 3Health News:2014 U.S. Open Tennis Tickets: Ticket Down Slashes Ticket Prices on All US Open Tennis Championship Sessions in New York at Arthur Ashe Stadium 4Health News:2014 U.S. Open Tennis Tickets: Ticket Down Slashes Ticket Prices on All US Open Tennis Championship Sessions in New York at Arthur Ashe Stadium 5Health News:Patient, tumor characteristics for high-mitotic rate melanoma 2Health News:News from Annals of Internal Medicine 2Health News:Seniors' Sleep Woes May Be Linked to Loss of Brain Cells 2Health News:Perkins Eastman Expands Presence in China 2Health News:Perkins Eastman Expands Presence in China 3
... claimed 75 lives in Assam and the health authorities said ... ,"So far 75 people have died of cerebral malaria ... of April," Assam Health Minister Bhumidhar Barman told IANS. ... but fatalities have been reported only in Assam, which has ...
... Canada, affecting some 5% of people over the age of ... age of 85 suffer from the disease. According to the ... researcher working on Alzheimer's disease at the University of Toronto ... is the cause of the disease. The researchers have discovered ...
... southwest China's Sichuan province was confirmed to be infected ... ,The girl, surnamed Sun, from Tangjia township in ... pneumonia April 16. She was being treated in a ... reported that poultry deaths occurred in the patient's house ...
... (FDA) has categorically ruled out endorsing the use of ... of Medicine report in 1999, which had said that ... conditions like AIDS wasting, chemotherapy induced nausea and vomiting ... statement issued on Thursday, the FDA stated that "no ...
... asthma symptoms in people with allergic asthma. Dust mites, tiny ... cause of allergic reactions. //The proteins present in the excrement ... to that of asthma. Hence the development of the dust ... is a Swiss vaccine company which manufactures this vaccine. As ...
... Manmohan Singh Wednesday announced that a Centre for India ... set up here// and praised the nearly 200 people ... for changing the image of the country here. ... have made India synonymous with quality and dependability, particularly ...
Cached Medicine News:Health News:Assam’s Malaria Death Toll Rises To 75, More People Affecte 2
(Date:8/20/2014)... , Aug. 20, 2014 Reportlinker.com ... is available in its catalogue: ... Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN ... http://www.reportlinker.com/p0652514/Wireless-Opportunities-in-Healthcare-The-Market-for-Bluetooth-RFID-Zigbee-UWB-WWAN-WMAN-WLAN-and-other-technologies.html Kalorama Information,s Wireless ... RFID, Zigbee, UWB WWAN, WMAN, WLAN and ...
(Date:8/20/2014)... Mass. , Aug. 20, 2014 /PRNewswire/ ... electrophysiology (EP) mapping and ablation device market ... use ablation to treat atrial fibrillation (AF). ... primary treatment option for AF will spur ... this application, such as advanced loop diagnostic ...
(Date:8/20/2014)... NEW YORK , Aug. 20, 2014 ... available in its catalogue: Global Feminine Hygiene ... This report analyzes the worldwide markets for Feminine ... Segments: Sanitary Pads/Towels, Tampons, Panty liners, and Others. The ... Canada , Japan , ...
Breaking Medicine Technology:Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 2Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 3Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 4Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 5Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 6Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 7Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 8Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 9Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 10Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 11Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 12Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 13Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 14Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 15Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 16Electrophysiology Mapping and Ablation Device Market in Japan to Reach $1.1 Billion by 2023 2Electrophysiology Mapping and Ablation Device Market in Japan to Reach $1.1 Billion by 2023 3Global Feminine Hygiene Products Industry 2Global Feminine Hygiene Products Industry 3Global Feminine Hygiene Products Industry 4Global Feminine Hygiene Products Industry 5Global Feminine Hygiene Products Industry 6Global Feminine Hygiene Products Industry 7Global Feminine Hygiene Products Industry 8Global Feminine Hygiene Products Industry 9Global Feminine Hygiene Products Industry 10Global Feminine Hygiene Products Industry 11Global Feminine Hygiene Products Industry 12Global Feminine Hygiene Products Industry 13Global Feminine Hygiene Products Industry 14Global Feminine Hygiene Products Industry 15Global Feminine Hygiene Products Industry 16Global Feminine Hygiene Products Industry 17Global Feminine Hygiene Products Industry 18Global Feminine Hygiene Products Industry 19
... , PITTSBURGH, Sept. 30 ThermalTherapeutic Systems, Inc., ... standardize hyperthermic perfusion announced today the completion of ... After receiving initial start-up funding by the Pittsburgh ... financing which included follow-on investments by the Pittsburgh ...
... Fifty-nine percent of all prescriptions filled ... to a research report published this month in ... from Thomson Reuters and the federal Substance Abuse and ... psychotropic drugs from August 2006 through July 2007. ...
Cached Medicine Technology:ThermalTherapeutic Systems Completes $2.75 Million Series A Financing With Originate Ventures 2General Practitioners Write Most Prescriptions for Mental Health Drugs, According to Study from Thomson Reuters and SAMHSA 2
The Auto Suture DFS stapler is a disposable fascia stapler. The stapler places one staple each time the instrument handles are activated. The staples first penetrate the fascia and are then formed, t...
... PROXIMATE PLUS MD Skin Stapler is a ... deliver rectangular, stainless steel staples for routine ... Skin Stapler is supplied sterile and preloaded ... ,PROXIMATE Skin Staplers place single staples ...
... Single use, reloadable articulating (22° and ... linear stapler handle for resection, transection and ... ,The stapler places two triple-staggered rows ... the tissue in between. The instrument is ...
... two staggered rows of titanium staples in ... is available in two sizes to accommodate ... 30mm staple line while the 60mm instruments ... PROXIMATE Vascular Linear Stapler delivers three staggered ...
Medicine Products: