Navigation Links
Scripps Florida scientists devise accelerated method to determine infectious prion strains
Date:5/28/2009

nfectious agent, called a prion, cause mad cow disease, chronic wasting disease, and different forms of scrapie and human Creutzfeldt-Jacob disease.

Mad cow disease has had devastating consequences for bovine livestock populations, particularly in Europe, and for humans who have consumed contaminated beef products.

To date, there have been more than 200 recorded human fatalities worldwide due to mad cow disease. Creutzfeldt-Jacob disease, a low-incidence but always fatal disease, affects humans in all countries.

Prions consist mainly or entirely of an abnormal form of a normal cellular protein. They multiply by converting their normal counterparts into a likeness of themselves, which may aggregate to form deposits called amyloid. Accumulation of different kinds of amyloid plays a role in a wide range of neurodegenerative diseases, including Alzheimer's and Parkinson's diseases.

Currently, different varieties of prion strains are identified in mouse models according to incubation time, clinical symptoms, and localization of brain lesions.

Accelerated Incubation

In the new test developed by Lasmzas and Weissmann, a transgenic mouse line called Tga20 plays an important role, because it succumbs rapidly to prion disease.

"The prions primarily target the brainstem and the thalamus of this transgenic mouse, explaining why these animals have a shorter incubation time than their normal counterparts," Lasmzas said. "The prion aggregates also don't spread evenly to other brain regions, and their distribution is characteristic for different strains."

Importantly, the brain tissue can be subjected to the Cell Panel Assay, which unlike the current histological method, doesn't require time intensive examination of brain lesions and can be completed within two weeks, Lasmzas added. The test has been partially automated.

Development of the method provided the scientists with the opportunit
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scripps Research scientists shed new light on how antibodies fight HIV
2. Scripps Health Treats More Than 160 Fire Victims at Emergency Departments Across San Diego County
3. Scripps research scientists discover chemical triggers for aggression in mice
4. Scripps research scientists find new genetic mutation that halts the development of lupus
5. Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells
6. Scripps scientists peg wind as the force behind fish booms and busts
7. Scripps research scientists devise approach that stops HIV at earliest stage of infection
8. Scripps Florida awarded $7.6 million grant to develop novel treatment for Parkinsons disease
9. Scripps research team wins $4M grant to study effects of chronic marijuana use
10. Scripps Florida scientists develop a process to disrupt hepatitis C virion production
11. Scripps Memorial Hospital Nurses Throw Out CNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... 31, 2014 The 2013 edition ... about chemical listings, appellate decisions, litigation and settlement ... affect compliance with California's Proposition 65. , The ... law, regulations, history and trends impacting California's Proposition ... installment of the series which adds approximately 200 ...
(Date:7/31/2014)... (August 1, 2014) If you have asthma, you may ... to help you recognize and respond to changes and understand ... you,re in the green zone, you,re doing well, yellow means ... means you require urgent care. New guidelines are now available ... zone, back into green and away from the red zone. ...
(Date:7/31/2014)... Developer Jamestown, L.P., has been using ... City Market project in Atlanta’s Old Fourth Ward, which ... building into best-in-class office, housing, and retail spaces. As ... with their construction webcam service to assess how it ... construction camera for monitoring and documentation purposes, ...
(Date:7/31/2014)... Hoping to attract new customers who are ... , NutriGold is ready to ship out free samples of ... advantage of this offer fast and easy: http://www.nutrigold.com/Free-Samples ... at NutriGold, "We know that every time customers purchase one ... precious asset: their own health or the health of a ...
(Date:7/31/2014)... has announced that they are now offering a new ... Review of Sexual Satisfaction . The course is ... Clinical and Health Psychology. , This CE course has ... accurate information about sexual satisfaction so that healthcare professionals ... provides a systematic review of 197 research publications in ...
Breaking Medicine News(10 mins):Health News:Save 25% on the Proposition 65 Handbook - 2013 Edition Through August 31 2Health News:OxBlue Construction Webcam Proves Valuable Tool for Developer, Consumers on Historic Ponce City Market Project 2Health News:OxBlue Construction Webcam Proves Valuable Tool for Developer, Consumers on Historic Ponce City Market Project 3Health News:NutriGold Launches Product Samples Page for its Supplements 2Health News:NutriGold Launches Product Samples Page for its Supplements 3Health News:Company Provides New Course on Sexual Satisfaction 2Health News:Company Provides New Course on Sexual Satisfaction 3
... linked to iron deficiency, intravenous administration of iron increases ... says a Turkish study. ,Since oral iron replacement ... first choice for treatment for iron-deficiency anemia, Dr. Ragip ... it seems that intravenous iron sucrose is a safe ...
... 'small is good' and those small portions help us keep over ... pour 20-30% more alcohol // into short , wide glasses than ... believe that tall glasses hold more. The study finds mention ... public but seasoned and professional bartenders do the same mistake or ...
... of Jharkhand has given health the status of industry. ... to receive all facilities provided under the industrial policy. ... and infrastructure support. ,The government move is ... the health sector in state, where half the population ...
... Woods with other scientists from British Cardiac Society, ... the Primary Care Cardiovascular Society // and ... preventing cardiovascular risks of heart attacks, stroke and ... drafted to reduce the risk of developing heart ...
... of Medicine in St. Louis has found that survivors of ... as depressed as some studies make them out to be ... December issue of Supportive Care in Cancer. ,This study ... Center at Washington University School of Medicine and Barnes-Jewish Hospital. ...
... in the December 21 issue of the Journal of the ... radiation reduces the ability // to repair the chromosomal damage ... developing basal cell carcinoma and squamous cell carcinoma. ... is responsible for breaking DNA strands in exposed skin cells. ...
Cached Medicine News:Health News:Intravenous Iron treats anemia of pregnancy faster 2
(Date:7/31/2014)...  A substantial share of pharmacy and therapeutics ... are included in formularies—say patient support resources from ... Manhattan Research study, Taking the Pulse® Formulary ... P&T committee members in hospitals, managed care organizations ... a high bar for these programs, requiring that ...
(Date:7/31/2014)... FRANCISCO , July 31, 2014 ... and Aspira Scientific ( Milpitas, California ... venture to develop and commercialize new fluorination products ... active molecules has benefited from the use of ... and combine lipophilicity with polarity to improve binding ...
(Date:7/31/2014)... , July 31, 2014 For the ... can watch the implantation of the SynCardia temporary Total ... and matching video posted on the Journal of Visualized ... and read the paper on the SynCardia Total Artificial ... 16-minute video accompanies "Implantation of the SynCardia Total Artificial ...
Breaking Medicine Technology:Formulary Decision Makers Say Pharma-Provided Patient Support Solutions Influence Formulary Placement 2Formulary Decision Makers Say Pharma-Provided Patient Support Solutions Influence Formulary Placement 3Catylix, Inc. and Aspira Scientific Announce Joint Venture to Commercialize New Fluorination Technologies 2How to Implant the SynCardia Total Artificial Heart Detailed in Peer Reviewed Paper and Matching Video 2How to Implant the SynCardia Total Artificial Heart Detailed in Peer Reviewed Paper and Matching Video 3
... N.J. and EDISON, N.J., June 8, 2011 ... they had entered into a broad-based collaboration agreement ... products. Under the terms of the agreement, AustarPharma ... manufacture products for Amerigen to commercialize in the ...
... Hospital ORs and ASCs (ambulatory surgery centers) face staffing ... to delegate non-care related tasks such as instrument purchasing ... Surgical, a 20+-year provider of high-quality specialty surgical ... an informed supply partner: Surgical instruments have ...
Cached Medicine Technology:Amerigen Pharmaceuticals and AustarPharma Enter Into Collaboration Agreement for Generic Oral Controlled Release Products 2Millennium Surgical's Smart Instrument Purchasing Saves OR Personnel Time, Money 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: