Navigation Links
Scripps Florida scientists develop new compound that reverses fatty liver disease
Date:12/19/2012

JUPITER, FL, December 19, 2012 Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed the first synthetic compound that can reverse the effects of a serious metabolic condition known as fatty liver disease. True to its name, the disease involves an abnormal buildup of fat in the liver.

The compoundknown as SR9238is the first to effectively suppress lipid or fat production in the liver, eliminating inflammation and reversing fat accumulation in animal models of fatty liver disease. The new compound also significantly lowered total cholesterol levels, although precisely how that occurred remains something of a mystery.

"We've been working on a pair of natural proteins called LXRα and LXRβ that stimulate fat production in the liver, and we thought our compound might be able to successfully suppress this process," said Thomas Burris, a professor at TSRI who led the study, which was recent published in an online edition of the journal ACS Chemical Biology. "Once the animals were put on the drug, we were able to reverse the disease after a single month with no adverse side effectswhile they ate a high-fat diet."

Fatty liver, which often accompanies obesity and type 2 diabetes, frequently leads to more serious conditions including cirrhosis and liver cancer. The condition affects some 10 to 24 percent of the general population, according to a 2003 study in GUT, an international journal of gastroenterology and hepatology.

Burris and his colleagues designed SR9238 so that it would be quickly metabolized in the liver to minimize migration of the drug into the bloodstream, which could lead to side effects.

In the study, mice were fed a high-fat diet for 14 weeks prior to treatment with SR9238. After one month of treatment, the scientists found that the liver's fat-producing genes were repressed and fat expression in the liver was reduced up to 90 percent.

In addition, the scientists observed an 80 percent reduction of the enzyme responsible for producing cholesterol (3-Hydroxy-3-methylglutaryl coenzyme A Reductase)the same enzyme targeted by statins.

Markers for liver damage were down as well, which suggests the compound may also have the potential to treat alcohol-related fatty liver damage.


'/>"/>

Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute
Source:Eurekalert  

Related medicine news :

1. Scripps Florida scientist awarded $2.5 million to study inner workings of memory formation
2. Scripps Florida scientists uncover a novel cooperative effort to stop cancer spread
3. Scripps Research Institute study points to potential new therapies for cancer and other diseases
4. 2 Scripps Research Institute scientists honored by American Chemical Society
5. Scripps studies show community-based diabetes programs are key to lowered costs and improved care
6. Scripps Research Institute receives $20 million to shed light on HIV drug resistance
7. Scripps Research Institute scientists show protein linked to hunger also implicated in alcoholism
8. Scripps Research scientists devise powerful new method for finding therapeutic antibodies
9. Clinical trials start for stroke drug developed by Scripps Research, USC, and ZZ Biotech
10. Scripps Florida scientists awarded nearly $1.5 million to develop new approaches to treat cancer
11. Scripps Research scientists show how memory B cells stay in class to fight different infections
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Florida scientists develop new compound that reverses fatty liver disease
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal their media with ... X," said Christina Austin - CEO of Pixel Film Studios. , ProSlice Color ... users can now reveal the media of their split screens with growing colorful ...
(Date:6/27/2016)... ... ... TopConsumerReviews.com recently awarded their highest five-star rating to Best Buy Eyeglasses, an ... United States and Canada wear eyeglasses. Once considered to be a purely functional part ... fashion statement. Even celebrities use glasses as a way of creating an iconic image—like ...
(Date:6/26/2016)... ... 2016 , ... PawPaws brand pet supplements owned by Whole Health ... the health of felines. The formula is all-natural and is made from Chinese herbs ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia ...
(Date:6/25/2016)... Austin, TX (PRWEB) , ... June 25, 2016 , ... ... Fellow of the American College of Mohs Surgery and to Dr. Russell Peckham for ... popular and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Bracket , a ... its next generation clinical outcomes platform, Bracket eCOA (SM) ... on June 26 – 30, 2016 in Philadelphia ... electronic Clinical Outcome Assessment product of its kind to fully ... Bracket eCOA 6.0 is a flexible platform for ...
(Date:6/23/2016)... Revolutionary technology includes multi-speaker listening ... industry leaders in advanced audiology and hearing aid technology, ... ™, the world,s first internet connected hearing aid that ...      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) , ... ,world firsts,: , TwinLink™ - the first ...
(Date:6/23/2016)... , June 23, 2016  Experian Health, ... and transforming the patient payment and care ... innovative new products and services that will ... revenue cycle offerings. These award-winning solutions will ... workflows, remain compliant in an ever-changing environment ...
Breaking Medicine Technology: