Navigation Links
Scripps Florida scientists develop a process to disrupt hepatitis C virion production
Date:3/21/2008

HCV is a significant human pathogen, infecting more than three percent of the worlds population. The incidence of infection in the United States has been estimated to be as high as 4 million cases. In the March issue of the journal PLoS Pathogens, Timothy Tellinghuisen, an assistant professor in the Department of Infectology at Scripps Florida, and his colleagues describe how they used mutations of the viral NS5A phosphoprotein to disrupt virus particle production at an early stage of assembly. NS5A has long been proposed as a regulator of events in the HCV life cycle, but exactly how it orchestrates these events has been unclear.

The interesting thing about this mutant is that while it triggers totally normal RNA replication, it causes severe defects in the output of infectious virusin fact, it releases no infectious virus that we can detect, says Tellinghuisen. And though this discovery isnt a cure for HCV, it is an important research tool that stops the assembly pathway. Total disruption of the replication process would be a cure for the disease, he adds, and thats the teams long-term goal.

HCV infection is roughly five to seven times more prevalent than HIV, underscoring the pandemic nature of HCV infection. HCV occurs when blood from an infected person enters the body of someone who is not infected. Most new HCV infections are due to illegal drug injections and sharing needles. However, those who had blood transfusions prior to blood donor screening in 1991, healthcare workers who had needle stick accidents, and hemodialysis patients are also at risk for developing HCV infection. The virus predominantly infects the liver, and following many decades of virus reproduction serious disease such as hepatitis (liver inflammation), cirrhosis (liver scarring), and carcinoma (liver cancer) develop. Ultimately, HCV infection destroys the liver, resulting in death. Attempts at curing HCV infections with drug therapy have been only marginally succes
'/>"/>

Contact: Keith McKeown
kmckeown@scrpps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scripps Research scientists shed new light on how antibodies fight HIV
2. Scripps Health Treats More Than 160 Fire Victims at Emergency Departments Across San Diego County
3. Scripps research scientists discover chemical triggers for aggression in mice
4. Scripps research scientists find new genetic mutation that halts the development of lupus
5. Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells
6. Scripps scientists peg wind as the force behind fish booms and busts
7. Scripps research scientists devise approach that stops HIV at earliest stage of infection
8. Scripps Florida awarded $7.6 million grant to develop novel treatment for Parkinsons disease
9. Scripps research team wins $4M grant to study effects of chronic marijuana use
10. Owner and Operator of Florida Durable Medical Equipment Company Convicted of Medicare Fraud
11. PainCare Receives $14.4 Million in Cash From Completed Sale of South Florida Ambulatory Surgery Centers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/26/2014)... As the category creator and world leader ... Xoçai is to transform and improve individual ... products. One such unique element is XoVita™, a ... blueberries, an ingredient combination exclusive to Xoçai. This ... all of Xoçai products and provides a wide-ranging ...
(Date:7/25/2014)... 2014 2014 Deep Research ... Chromatography Industry” is a professional and in-depth ... Gel Permeation Chromatography market. The report provides ... Permeation Chromatography definition, classification, application, and industry ... This research covers the international market analysis, ...
(Date:7/25/2014)... 2014 American motor vehicle owners who ... can pay higher premiums for vehicle insurance on average. ... network to provide SR22 insurance for high risk motorists ... different coverage network of local agencies providing direct price ... platform now publicly available for any car owner to ...
(Date:7/25/2014)... Ticket Down announces that they ... Guinness International Champions Cup match between international soccer powerhouses ... on Sunday, July 27th. This well-known ticket ... SOCCER-2014 for added savings. , 2014 is turning out ... in North America. Countless international soccer teams have been ...
(Date:7/25/2014)... 2014 Sport Court® provided ... Nike National Invitational Tournament (NIT) in Chicago ... Junior National Tournament (USJN) in Washington D.C. at ... for these prestigious national tournaments included 44 Sport Court ... of playing surface at McCormick Place for the NIT, ...
Breaking Medicine News(10 mins):Health News:Xocai-Asia Japanese Distributors in Hachioji, Japan Sanction Local Single-Source-Chocolate Investigative Report: MXI-Corp-Asia Discloses Direct-Sales Compensation Plan 2Health News:Xocai-Asia Japanese Distributors in Hachioji, Japan Sanction Local Single-Source-Chocolate Investigative Report: MXI-Corp-Asia Discloses Direct-Sales Compensation Plan 3Health News:Xocai-Asia Japanese Distributors in Hachioji, Japan Sanction Local Single-Source-Chocolate Investigative Report: MXI-Corp-Asia Discloses Direct-Sales Compensation Plan 4Health News:2014 China & Global GPC Industry - Gel Permeation Chromatography Development Trends Now at DeepResearchReports.com 2Health News:2014 China & Global GPC Industry - Gel Permeation Chromatography Development Trends Now at DeepResearchReports.com 3Health News:SR22 Insurance for High Risk Motorists Added to Local Quotes System at Insurer Website Online 2Health News:Liverpool FC vs. Olympiacos FC Tickets Soldier Field: Ticket Down Slashes Ticket Prices for Guinness International Champions Cup in Chicago on Sunday, July 27th 2Health News:Sport Court Provides All Sports Flooring for Basketball Events in Chicago and Washington D.C. 2
... , , ... outdoor ground-level ozone, microscopic particle pollution like smoke and smog, ... is sensitive to these airborne contaminants to experience shortness of ... and cause lung irritation(1). According to AIRNow.gov(2), a government-developed index ...
... is providing valuable new clues into cancer,s deadliest behavior -- ... spreading throughout the body. Duke University biologist David ... of a single cell in the developing body of a ... one of its jobs is to connect the developing animal,s ...
... EVANSTON, Ill. --- Anyone with an MP3 device -- just about every ... a notion of the majesty of music, of the primal place it ... be seen simply as stuff of the soul -- a frill that ... Northwestern University study. The study shows that musicians -- trained ...
... , , Congressman Chaka Fattah (D-PA) releases ... healthcare system. , , WASHINGTON, Aug. 17 "We ... If real reform is to take place it must include a public option. ... in any major city they deliberate how they will get to their destination. ...
... , NEWINGTON, N.H. Aug. 17 ... atmosphere have struck a chord with consumers, is being honored in ... private companies in America. , , (Logo: ... number 471 on the lnc. 500, which ranks the nation,s top ...
... , , , , ... community, announces its donation of a fully furnished two bedroom apartment ... their families to stay for free while undergoing care at the ... and availability, the managing partners of Presidential Towers felt that this ...
Cached Medicine News:Health News:Bad Air Day Alert: Outdoor Air Pollutants at High Level 2Health News:Bad Air Day Alert: Outdoor Air Pollutants at High Level 3Health News:Cancer's break-in tools possibly identified at Duke 2Health News:Taking up music so you can hear 2Health News:Taking up music so you can hear 3Health News:Planet Fitness Soars to Inc. 500 2Health News:Presidential Towers Donates Apartment to the University of Illinois Medical Center 2
(Date:7/25/2014)... Dr. Michael Gabriel of a prominent Staten ... study, which shows how grief in pregnancy may cause obesity ... According to US News , "Unborn children ... others to grow up overweight or obese, even if that ... specific types of stress that caused obesity: "Children whose biological ...
(Date:7/24/2014)... MARSEILLE , Frankreich, July 24, ... , Weltweite Exklusivlizenz der Universität ... von Tests auf SF3B1-Mutationen, einschließlich von Next-Generation-Sequencing ... Test weist Mutationen des SF3B1-Gens nach, die ... günstigen Krankheitsverlauf vermuten lassen  QIAGEN ...
(Date:7/24/2014)... , July 24, 2014  IRIDEX Corporation (NASDAQ: ... release its second quarter 2014 financial results after the ... In conjunction with the release, the Company will host ... 5:00 p.m. Eastern Time on Thursday, July ... quarter and other business developments. Interested parties ...
Breaking Medicine Technology:Dr. Michael Gabriel of GPM Pediatrics, a Noted Staten Island Pediatrics Clinic, Comments on Study, Which Names Grief as a Cause of Obesity in Children 2QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 2QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 3QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 4QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 5
... Inc. and Cedarlane today announced that they have entered ... distribute high value reagent proteins produced by Pfenex to ... products initially distributed will be vaccine carrier proteins such ... related growth factors including G-CSF and Interferon beta 1-b. ...
... Research Group, Inc. recently published its TreatmentTrends®: Vascular ... based on online survey results from ... interventional nephrologists). It provides an in-depth view of the ... to both vascular access placement and maintenance.   ...
Cached Medicine Technology:Pfenex Inc. Establishes Reagent Protein Distribution Agreement With Cedarlane Corporation 2Latest BioTrends Report Provides Comprehensive Market Landscape of the Dialysis Vascular Access Market 2
PDA format of the well-known standard antimicrobial reference....
PDA application providing a complete guide for the diagnosis and management of electrolyte disorders....
Contains the most common procedures from all orthopedic sub-specialties organized by body area....
Consists of the print and PDA versions of Harrison's Manual of Medicine 15th Edition. Provides high-end medical content via PDA....
Medicine Products: