Navigation Links
Scripps Florida scientists awarded nearly $1.5 million to develop new approaches to treat cancer
Date:8/6/2012

JUPITER, FL, August 3, 2012 Scientists from the Florida campus of The Scripps Research Institute have been awarded approximately $1.5 million from the National Institutes of Health to identify and develop new therapeutic approaches against a broad spectrum of cancers.

John Cleveland, professor and chair of the Department of Cancer Biology, and Derek Duckett, associate scientific director of the Translational Research Institute at Scripps Florida, will act as co-principal investigators.

The new three-year grant will allow the Scripps Florida scientists to develop high-throughput screening tests to identify and optimize inhibitors of the "autophagy pathway," the principal recycling center of the cell, which is especially active during times of stress or nutrient loss. During autophagy, various cell components, including damaged proteins and mitochondria, are delivered to the lysosome, which is essentially a bag of enzymes that breaks down cellular waste.

Autophagy is critical to cell survival and defects in the pathway can lead to a number of disorders, including some neurodegenerative and muscular diseases.

"We have shown that impairing autophagy can improve the efficacy of anti-cancer drugs, helping to overcome drug resistance," Cleveland said. "Although there's a lot of interest in generating compounds to act on specific components of the pathway, none exist now. The new grant will, hopefully, help us begin to remedy that situation."

Duckett added, "Our studies have shown that impairing the autophagy pathway increases the sensitivity of cancer cells to conventional therapeutics, so this is a highly practical and productive approach to developing potential treatments."

With the new funding, the scientists will develop a novel biochemical test to identify inhibitors of the UNC-51-like kinase (Ulk1), a critical on-off switch that regulates the pathway. Once identified, these small molecules will also help scientists improve their basic understanding of autophagy, its relationship to cancer, and its use as a target that could enhance the action of conventional anti-cancer therapeutics.

The funding was granted by the National Cancer Institute of the National Institutes of Health under award number CA169142.


'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Related medicine news :

1. Scripps Research scientists show how memory B cells stay in class to fight different infections
2. Chinese Drywall Complaint Center Now Demands Leadership From Obama & EPA, For Homeowners In Florida And In The US Southeast Stuck In Toxic Chinese Drywall Hell-Forward?
3. Scientists solving the mystery of human consciousness
4. Scientists uncover multiple faces of deadly breast cancer
5. Scientists identify major source of cells defense against oxidative stress
6. Scientists tailor cell surface targeting system to hit organelle ZIP codes
7. Scientists rewrite rulebook on breast cancer in landmark global study
8. Warwick scientists uncover how checkpoint proteins bind chromosomes
9. NIH scientists link quickly spreading gene to Asian MRSA epidemic
10. Joslin scientists identify important mechanism that affects the aging process
11. Scientists Map Melanomas Genome
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Florida scientists awarded nearly $1.5 million to develop new approaches to treat cancer
(Date:5/5/2016)... ... May 05, 2016 , ... VisualDx ... devices. VisualDx is the first point of care diagnostic support system to ... The system speeds diagnosis, therapy decisions and patient education for emergency physicians, ...
(Date:5/5/2016)... ... ... summer is just around the corner. Summer means a lot of different things to people. ... play all day and night. Parents often lament the coming of summer as they will ... means trips to the beach, backyard cookouts, fireworks on the Fourth of July, and even ...
(Date:5/5/2016)... ... May 05, 2016 , ... Dermatologic surgeons performed nearly 10 ... and up 27 percent since 2012. , The results of the 2015 ASDS Survey ... increase in skin cancer treatments and the growing popularity of soft-tissue fillers and body ...
(Date:5/5/2016)... Washington, DC (PRWEB) , ... ... ... Contact: Claudia Tellez, Executive Director 703.462.0658, ctellez(at)msnva.org , The Medical Society of ... community physicians and their patients , The Medical Society of Northern Virginia ...
(Date:5/5/2016)... ... , ... Nepenthe Laboratory Services (NLS), a premier drug monitoring and toxicology laboratory, ... item donations for Food for Lane County, and to help support awareness for the ... the assembly was to create an exciting atmosphere for the kids at Riverbend to ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... , May 5, 2016 Research ... for PET Imaging in the USA"  report to their ... provides information on the current Positron Emission Tomography (PET) ... USA market. Along with the current known ... USA , the report also contains a ...
(Date:5/5/2016)... Research and Markets has ... Market and Competitive Landscape Highlights - 2016" ... (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) The ... Landscape Highlights - 2016, provides comprehensive insights ... market valuations and forecast, Thalassaemia products sales ...
(Date:5/4/2016)... Calif. , May 4, 2016  It,s time for an upgrade. There are ... on a brilliant 3.5 inch LCD, the illustrious DVMAXX HD  offers unparalleled connectivity ... as well as a world class manufacturer of innovative technology.  Photo - ... ... ...
Breaking Medicine Technology: