Navigation Links
Scripps Florida scientists awarded nearly $1.5 million to develop new approaches to treat cancer

JUPITER, FL, August 3, 2012 Scientists from the Florida campus of The Scripps Research Institute have been awarded approximately $1.5 million from the National Institutes of Health to identify and develop new therapeutic approaches against a broad spectrum of cancers.

John Cleveland, professor and chair of the Department of Cancer Biology, and Derek Duckett, associate scientific director of the Translational Research Institute at Scripps Florida, will act as co-principal investigators.

The new three-year grant will allow the Scripps Florida scientists to develop high-throughput screening tests to identify and optimize inhibitors of the "autophagy pathway," the principal recycling center of the cell, which is especially active during times of stress or nutrient loss. During autophagy, various cell components, including damaged proteins and mitochondria, are delivered to the lysosome, which is essentially a bag of enzymes that breaks down cellular waste.

Autophagy is critical to cell survival and defects in the pathway can lead to a number of disorders, including some neurodegenerative and muscular diseases.

"We have shown that impairing autophagy can improve the efficacy of anti-cancer drugs, helping to overcome drug resistance," Cleveland said. "Although there's a lot of interest in generating compounds to act on specific components of the pathway, none exist now. The new grant will, hopefully, help us begin to remedy that situation."

Duckett added, "Our studies have shown that impairing the autophagy pathway increases the sensitivity of cancer cells to conventional therapeutics, so this is a highly practical and productive approach to developing potential treatments."

With the new funding, the scientists will develop a novel biochemical test to identify inhibitors of the UNC-51-like kinase (Ulk1), a critical on-off switch that regulates the pathway. Once identified, these small molecules will also help scientists improve their basic understanding of autophagy, its relationship to cancer, and its use as a target that could enhance the action of conventional anti-cancer therapeutics.

The funding was granted by the National Cancer Institute of the National Institutes of Health under award number CA169142.


Contact: Mika Ono
Scripps Research Institute

Related medicine news :

1. Scripps Research scientists show how memory B cells stay in class to fight different infections
2. Chinese Drywall Complaint Center Now Demands Leadership From Obama & EPA, For Homeowners In Florida And In The US Southeast Stuck In Toxic Chinese Drywall Hell-Forward?
3. Scientists solving the mystery of human consciousness
4. Scientists uncover multiple faces of deadly breast cancer
5. Scientists identify major source of cells defense against oxidative stress
6. Scientists tailor cell surface targeting system to hit organelle ZIP codes
7. Scientists rewrite rulebook on breast cancer in landmark global study
8. Warwick scientists uncover how checkpoint proteins bind chromosomes
9. NIH scientists link quickly spreading gene to Asian MRSA epidemic
10. Joslin scientists identify important mechanism that affects the aging process
11. Scientists Map Melanomas Genome
Post Your Comments:
Related Image:
Scripps Florida scientists awarded nearly $1.5 million to develop new approaches to treat cancer
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of ... Philippines. “The Journey: From the Mountains to the Mission Field” is the creation of ... taught all ages and currently teaches a class of ladies at her church, which ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... products to meet the demand of today’s consumer and regulatory authorities worldwide. From ... probiotic experts and tested to meet the highest standard. , These products ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa Mohebi, ... a medical article to the newly revamped Cosmetic Town journal section, ... hair transplant procedure known as Follicular Unit Extraction (FUE). , Dr. ...
(Date:10/12/2017)... ... , ... Health Literacy Innovations (HLI), creator of the Health ... Cancer Patient Education Network (CPEN), an independent professional organization that shares best practices ... , As CPEN’s strategic partner, HLI will help support CPEN members by ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... for their devotion to personalized service, SMP Pharmacy Solutions announces ... the South Florida Business Journal,s 50 Fastest-Growing Companies, and listed ... national specialty pharmacy has found its niche.  To that end, ... honored by SFBJ as the 2017 Power Leader in Health ... his award in October, Bardisa said of the three achievements, ...
(Date:9/22/2017)... , Sept. 22, 2017  As the latest ... Senators Bill Cassidy (R-LA) and Lindsey ... notes that the medical device industry is in an ... device tax, the 2.3% excise tax on medical device ... they also want covered patients, increased visits and hospital ...
(Date:9/18/2017)... PROVIDENCE, R.I. , Sept. 18, 2017 ... in the fields of bioinformatics and immune ... to develop a protective avian influenza A (H7N9) vaccine. ... is distantly related to seasonal influenza and ... approaches, which rely on prior exposure to be ...
Breaking Medicine Technology: