Navigation Links
Scripps Florida scientist awarded $2.3 million to study dengue fever and related viruses
Date:3/27/2014

JUPITER, FL March 27, 2014 The outbreak of dengue fever that infected some 20 people in Florida's Martin County late last year unnerved many who feared the tropical disease had once again established a foothold in Florida. The last outbreaks occurred in 2009 and 2010 in Key Westbefore that, the disease hadn't struck Florida in more than 70 years.

Now, scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded $2.3 million to study a category of viruses that cause dengue fever, West Nile, yellow fever and other diseases spread by mosquitoes and ticks. These diseases can result in flulike symptoms, extreme pain (dengue has been called "bone-break fever") and, in some cases, encephalitis.

This family of viruses, called "flavivirus," affect some 2.5 billion people worldwide and cause hundreds of thousands of deaths each year. There are no antiviral treatments and a just handful of vaccines that provide protection against only a few of these diseases.

The principal investigator for the new five-year study is TSRI Associate Professor Hyeryun Choe, who will lead the effort to understand the virus's mode of infection and how new therapies might interrupt it.

"Flavivirus uses a very clever method of infection," Choe said. "It's like using a side door to enter a house when the front door is locked."

The viruses take advantage of the process that normally occurs during programmed cell death. During programmed cell death ("apoptosis"), a lipid usually found on the inner side of the cell membranes, specifically phosphatidylserine (PS), shifts to the surface, making itself readily available to any passing cellular stranger. This is where the trouble begins.

When cells are dying from a flavivirus infection, their freshly exposed PS is grabbed by the exiting virus, and phagocytescells that devour invading pathogens and dead and dying cellsengulf the virus as if it were a dying cell. Once engulfed by the phagocyte, the virus quickly turns the cell's own biology on its head, forcing it to produce copies of the virus.

While some viruses (influenza A for example) do not use PS in their life cycle, the flavivirus exploits this opportunity to the hilt. Infection of cells by dengue or West Nile viruses is markedly enhanced when phagocytes express receptors that recognize and bind PS.

It appears, however, that flaviviruses use only a subset of these receptors. The high selectivity, and the potency with which some of these receptors promote flavivirus infection, suggest only a small number of receptors might be effectively targeted to treat these diseases.

"We want to understand which PS receptors contribute the most to flavivirus infections and how we might block them," Choe said. "Our studies are designed to offer insights useful in the development of new therapies."


'/>"/>
Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Related medicine news :

1. Scripps researchers recommend mobile compression device to prevent DVT after joint surgery
2. Scripps Florida scientists find regulator of amyloid plaque buildup in Alzheimers disease
3. Scripps Health Launches Pilot Study of Wireless Vital Signs Device
4. OKeeffe Foundation donates $250,000 to fund Scripps Florida neuroscience training program
5. Scripps Research study underlines potential of new technology to diagnose disease
6. Stemedica and Scripps to Jointly Investigate Therapeutic Effect of Ischemia Tolerant Mesenchymal Stem Cells (itMSC) and Stem Cell Factors in Lung Injury and Sepsis
7. Scripps Florida scientists create new approach to destroy disease-associated RNAs in cells
8. Scripps Florida scientists develop new compound that reverses fatty liver disease
9. Scripps Florida scientist awarded $2.5 million to study inner workings of memory formation
10. Scripps Florida scientists uncover a novel cooperative effort to stop cancer spread
11. Scripps Research Institute study points to potential new therapies for cancer and other diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... (PRWEB) , ... June 27, 2016 , ... Quality metrics ... yet in many ways they remain in the eye of the beholder, according to ... a publication of The American Journal of Managed Care. For the full issue, ...
(Date:6/26/2016)... ... ... legally blind and certified personal trainer is helping to develop a weight loss fitness plan ... fix the two major problems leading the fitness industry today:, , ... They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library ... City Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ... for fumigation is not a common occurrence, but a necessary one in the event that ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may suffer ... unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid ... healthy coping following a traumatic event. , Trauma sufferers tend to feel a range ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Research and ... Market for Companion Diagnostic Tests" report to their offering. ... for Companion Diagnostics The World Market for ... personalized medicine diagnostics. Market analysis in the report includes the ... Market (In Vitro Diagnostic Kits) by Region (N. America, EU, ...
(Date:6/24/2016)... , Belgium , June 24, ... VNRX), today announced the appointment of Dr. ... Directors as a Non-Executive Director, effective June 23, ... Audit, Compensation and Nominations and Governance Committees.  As ... Futcher will provide independent expertise and strategic counsel ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Market - Forecast to 2022" report to their offering. ... method for the patients with kidney failure, it replaces the ... from the patient,s blood and thus the treatment helps to ... chloride in balance. Increasing number of ESRD ...
Breaking Medicine Technology: