Navigation Links
Scripps Florida scientist awarded $2.2 million grant to study hepatitis C
Date:10/11/2011

JUPITER, FL, October 10, 2011 The Scripps Research Institute has been awarded a $2.2 million grant by the National Institutes of Health (NIH) to determine how the hepatitis C virus (HCV) induces liver cancer. The research could lead to potentially new therapeutic targets for treating those chronically infected with the virus.

Timothy Tellinghuisen, an assistant professor on the Florida campus of Scripps Research, is the principal investigator for the project.

Hepatitis C virus infection is a major public health problem worldwide. Estimates place the number of HCV infected individuals at approximately 170 to 200 million, representing nearly three percent of the world's population, according to the World Health Organization. HCV infection and its assorted pathologies are responsible for an estimated 250,000 deaths a year worldwide.

A majority of patients remain chronically infected, which can lead to progressive liver damage, cirrhosis, and often the development of hepatocellular carcinomaliver cancer. An estimated 60 to 70 percent of all those infected develop chronic infections and most progress to major liver damage. Each year, as many as five percent of these chronically infected patients will develop liver cancer.

While the mechanisms by which HCV induces liver cancer are largely unknown, Tellinghuisen's ongoing research points to host cell signaling pathways that are likely altered by the virus, creating a replication niche for the virus that avoids the body's innate immune system.

"We have identified a host proteincalled CARD14as an important factor for HCV RNA replication," he said. "We believe that a pathway regulated by this protein gets manipulated by the virus to maintain chronic infections and that this contributes, in part, to liver cancer development. The new grant will help us explore the extensive role of CARD14 in HCV replication and, quite possibly, identify new ways to attack chronic HCV infection
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Scripps Health Begins Pioneering Study of Human Tumor Sequencing in Cancer Patients
2. Top Scientists Explore the Origin of Life in Annual Lasker Lecture at Scripps Research Institute Florida Campus
3. Scripps Blood & Marrow Transplant Program Celebrates 30th Anniversary of Providing Life-Saving Care
4. Scripps Memorial Hospital La Jolla First in San Diego to Achieve Magnet Nursing Re-designation
5. Scripps Announces Plans for Region's First Proton Therapy Center; $185 Million Facility to Offer Advanced Care to Cancer Patients
6. Scripps Research scientists share $2 million in Florida state research grants
7. Scripps Center for Executive Health Now Offers Genetic Testing
8. Scripps Research scientists uncover previously unknown natural mechanism that controls cocaine use
9. NIH awards Scripps Florida scientists $2.3 Million to develop drug addiction treatments
10. Scripps Research scientists solve long-standing mystery of protein quality control mechanism
11. Scripps and Trius team up to develop new antibiotics with US Department of Defense grant
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Florida scientist awarded $2.2 million grant to study hepatitis C
(Date:11/28/2014)... a leader in the wig industry, has announced a great ... promotion features: , > 400 pieces of FOUR ... (no coupon code needed), > 10% off for ... $49 , Visit http://www.uniwigs.com for more details , The ... 1st and the first 100 shoppers each day will receive our ...
(Date:11/28/2014)... Patten Pecans, based in Lakeland, Georgia, ... passions driving them, they've added a pecan oil to ... pecans oils, they've found this pecan oil from ... flavorful, retaining the buttery pecan notes that are in ... found in pecans nuts is found in pecan ...
(Date:11/28/2014)... An inventor from Flint, Mich., wants to minimize ... this idea while lying in a hospital bed, unable to ... The Bed Buddy provides a more ergonomic and convenient way ... eliminates the need to leave the bed, which avoids hassle ... to use and producible in design variations, it's ideal for ...
(Date:11/28/2014)... 28, 2014 Before that Thanksgiving meal even ... for the Christmas shopping season. Today, people will stand in ... Friday, the biggest retail shopping day of the year. ... device, New Albany dentist Dr. Ronald Receveur is ... oral health and literally brighten a few smiles. , The ...
(Date:11/28/2014)... talklocal ( http://www.talklocal.com ) is launching in Denver, ... phone in about 90 seconds. , The launch comes ... to have touched down just north of the city on ... Denver residents now know all too well the value of ... local pros in over 50 service categories on speed dial ...
Breaking Medicine News(10 mins):Health News:Pre-X'mas Crazy Sale Starts from $0 at UniWigs.com 2Health News:Patten Pecans Goes Local with Nutritious Georgia Pecan Oil 2Health News:New Albany Dentist Offers Gift Ideas That Can Improve Oral Health 2Health News:New Albany Dentist Offers Gift Ideas That Can Improve Oral Health 3Health News:New Albany Dentist Offers Gift Ideas That Can Improve Oral Health 4Health News:TalkLocal Launches In Denver A Week After Multiple Tornadoes Hit Near City 2
... water in cold winter air tied to more influenza, study ... snow may seem like perfect incubators for the flu, but ... might be responsible for increases in influenza, such as those ... suggested that humidity is connected to seasonal epidemics of flu, ...
... , ... ... ... ...
... ... participate in a Buenos Aires Health Fair while learning Spanish. This program will enable ... environment while providing much-needed medical services to local residents. , ... (PRWEB) February 23, 2010 -- ECELA Spanish ...
... ... M2M, or Machine-to-Machine, refers to the communications between ... historic impediments to M2M solution deployment: system complexity and up-front costs. ... reduces the cost and time to build and deploy these applications. ...
... ... Last 2 Quarters Of 2009 , ... Pittsburgh, PA (PRWEB) February 23, 2010 -- Oncology Med, Inc. (Pink ... it expanded the number of contracts for its mobile turnkey brachytherapy programs by 300% ...
... ... everyone will carry their snacks while on the go. KUBBE is the first and ... hassle free. , ... 17, 2010 -- KUBBE is a trendy plastic utility buckle that allows people to carry ...
Cached Medicine News:Health News:Dry Weather Boosts Odds of Flu Outbreaks 2Health News:Cristophe Salon in Beverly Hills Teams Up with 'Mad Men' Actor to Help Raise Money for His 17-Year-Old Cousin's Heart Transplant 2Health News:Cristophe Salon in Beverly Hills Teams Up with 'Mad Men' Actor to Help Raise Money for His 17-Year-Old Cousin's Heart Transplant 3Health News:Cristophe Salon in Beverly Hills Teams Up with 'Mad Men' Actor to Help Raise Money for His 17-Year-Old Cousin's Heart Transplant 4Health News:ECELA Spanish School in Argentina Offers Students Opportunity to Work in Buenos Aires Free Health Fair 2Health News:ECELA Spanish School in Argentina Offers Students Opportunity to Work in Buenos Aires Free Health Fair 3Health News:Cloud Computing Platforms Address Unique M2M Application Needs, According To New SensorLogic White Paper 2Health News:Demand For Mobile Prostate Cancer Brachytherapy Vendor Programs Continues Into 2010 2Health News:Demand For Mobile Prostate Cancer Brachytherapy Vendor Programs Continues Into 2010 3Health News:Demand For Mobile Prostate Cancer Brachytherapy Vendor Programs Continues Into 2010 4Health News:Demand For Mobile Prostate Cancer Brachytherapy Vendor Programs Continues Into 2010 5
(Date:11/26/2014)... YORK and LONDON , ... of market intelligence, MarketResearch.com is pleased to announce the ... and Consultancy focusing on the active pharmaceutical ingredient (API) ... visit: http://www.marketresearch.com/land/publisher.asp?vendorid=4023&progid=86891 . In IQ4I,s ... – Forecast to 2020 , IQ4I ...
(Date:11/26/2014)...  At the American Dental Association,s Annual Meeting in ... Kerr Group was honored to be part of the ... to see and test the Best of Class winners ... on the latest developments in dental technology. This year, ... CariVu Caries Detection Device and Kerr Demi ™  ...
(Date:11/26/2014)... , Nov. 25, 2014 Reinforcing its ... Philips (NYSE: PHG AEX: PHIA) ... Drug Administration (FDA) for its IQon Spectral CT ... This first-of-its kind technology adds a new dimension to ... the ability to characterize structures based on their material ...
Breaking Medicine Technology:MarketResearch.com: Active Pharmaceutical Ingredient Market to Reach $175 Billion by 2020 Says IQ4I Report 2MarketResearch.com: Active Pharmaceutical Ingredient Market to Reach $175 Billion by 2020 Says IQ4I Report 3KaVo Kerr Group Showcased in Pride Institute Technology Expo at ADA Annual Meeting 2KaVo Kerr Group Showcased in Pride Institute Technology Expo at ADA Annual Meeting 3Philips receives FDA 510(k) clearance for IQon Spectral CT 2Philips receives FDA 510(k) clearance for IQon Spectral CT 3
... NASHVILLE, Tenn., May 11, 2011 Cumberland Pharmaceuticals ... pharmaceutical company focused on hospital acute care and gastroenterology ... overview at the 2011 UBS Global Specialty Pharmaceuticals Conference ... p.m. The presentation will be simultaneously ...
... S.C., May 11, 2011 /PRNewswire-USNewswire/ -- ... announced that two client companies received big check investment ... Therapeutics and EnviroMix, both technology-based start-ups located in the ... technology and business model. Madeira Therapeutics was ...
Cached Medicine Technology:SC Launch Presents "Big Check" Investment to Two South Carolina Companies 2SC Launch Presents "Big Check" Investment to Two South Carolina Companies 3
Surgical Stainless Steel Child Stylette....
Aluminum Stylette 16....
FlexiSlip™ Plastic coated malleable metal core. Single use, Sterile, Latex Free. Soft distal tip flexes to reduce risk of trauma to patient. Malleable metal core is easy to shape. Low friction ...
Slick® Disposable Endotracheal Stylet, Nylon-coated wire, Malleable core, Sureloc Stop helps maintain desired length for patient safety. Handle forming capability for better grip. Sterile. Single...
Medicine Products: