Navigation Links
Scripps Florida scientist awarded $2.2 million grant to study hepatitis C
Date:10/11/2011

JUPITER, FL, October 10, 2011 The Scripps Research Institute has been awarded a $2.2 million grant by the National Institutes of Health (NIH) to determine how the hepatitis C virus (HCV) induces liver cancer. The research could lead to potentially new therapeutic targets for treating those chronically infected with the virus.

Timothy Tellinghuisen, an assistant professor on the Florida campus of Scripps Research, is the principal investigator for the project.

Hepatitis C virus infection is a major public health problem worldwide. Estimates place the number of HCV infected individuals at approximately 170 to 200 million, representing nearly three percent of the world's population, according to the World Health Organization. HCV infection and its assorted pathologies are responsible for an estimated 250,000 deaths a year worldwide.

A majority of patients remain chronically infected, which can lead to progressive liver damage, cirrhosis, and often the development of hepatocellular carcinomaliver cancer. An estimated 60 to 70 percent of all those infected develop chronic infections and most progress to major liver damage. Each year, as many as five percent of these chronically infected patients will develop liver cancer.

While the mechanisms by which HCV induces liver cancer are largely unknown, Tellinghuisen's ongoing research points to host cell signaling pathways that are likely altered by the virus, creating a replication niche for the virus that avoids the body's innate immune system.

"We have identified a host proteincalled CARD14as an important factor for HCV RNA replication," he said. "We believe that a pathway regulated by this protein gets manipulated by the virus to maintain chronic infections and that this contributes, in part, to liver cancer development. The new grant will help us explore the extensive role of CARD14 in HCV replication and, quite possibly, identify new ways to attack chronic HCV infection
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Scripps Health Begins Pioneering Study of Human Tumor Sequencing in Cancer Patients
2. Top Scientists Explore the Origin of Life in Annual Lasker Lecture at Scripps Research Institute Florida Campus
3. Scripps Blood & Marrow Transplant Program Celebrates 30th Anniversary of Providing Life-Saving Care
4. Scripps Memorial Hospital La Jolla First in San Diego to Achieve Magnet Nursing Re-designation
5. Scripps Announces Plans for Region's First Proton Therapy Center; $185 Million Facility to Offer Advanced Care to Cancer Patients
6. Scripps Research scientists share $2 million in Florida state research grants
7. Scripps Center for Executive Health Now Offers Genetic Testing
8. Scripps Research scientists uncover previously unknown natural mechanism that controls cocaine use
9. NIH awards Scripps Florida scientists $2.3 Million to develop drug addiction treatments
10. Scripps Research scientists solve long-standing mystery of protein quality control mechanism
11. Scripps and Trius team up to develop new antibiotics with US Department of Defense grant
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Florida scientist awarded $2.2 million grant to study hepatitis C
(Date:7/13/2014)... York (PRWEB) July 13, 2014 The ... http://www.transvaginalmeshlawsuithelp.com/ ) filed against Johnson & Johnson’s ... bellwether trial, which is expected to get underway next ... in the U.S. District Court, Southern District of West ... be held on August 7, 2014 at 3:00 p.m. ...
(Date:7/13/2014)... Texas (PRWEB) July 13, 2014 Epidemiologists ... aGVHD in the 6MM, from 8,062 diagnosed incident cases ... at an Annual Growth Rate (AGR) of 4.35%, during ... the highest number of diagnosed incident cases of aGVHD ... Spain will have the lowest number of diagnosed incident ...
(Date:7/13/2014)... Columbus, OH (PRWEB) July 13, 2014 ... by Wright & Schulte LLC to provide consumers with ... can sometimes accompany use of the blood-thinning medication, as ... lawsuits pending in courts around the country. The ... anyone who may have suffered from life-threatening internal bleeding ...
(Date:7/13/2014)... Wa (PRWEB) July 13, 2014 According ... Vkool.com, this is a comprehensive program that teaches people ... peripheral neuropathy without medications. This program also ... relieving symptoms of peripheral neuropathy , including numbness, prickling, ... in its review that this home treatment program can ...
(Date:7/12/2014)... (PRWEB) July 13, 2014 Recently, iFitDress.com, one ... new selection of red evening gowns . What’s more, ... to 56% off. , The company’s senior spokesman states, “We ... shopping on our website is an enjoyable shopping experience. In ... In our online store, low prices do not always mean ...
Breaking Medicine News(10 mins):Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 2Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 3Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 4Health News:Graft-Versus-Host Disease Market (GVHD) Growing at 4.35% AGR to 2023 Says a New Report Available at ReportsnReports.com 2Health News:Graft-Versus-Host Disease Market (GVHD) Growing at 4.35% AGR to 2023 Says a New Report Available at ReportsnReports.com 3Health News:Graft-Versus-Host Disease Market (GVHD) Growing at 4.35% AGR to 2023 Says a New Report Available at ReportsnReports.com 4Health News:Xeralto Lawsuit Page Launched By Wright & Schulte LLC To Provide Information On Potential For Xarelto Bleeding Side Effects, Growing Litigation 2Health News:Xeralto Lawsuit Page Launched By Wright & Schulte LLC To Provide Information On Potential For Xarelto Bleeding Side Effects, Growing Litigation 3Health News:Xeralto Lawsuit Page Launched By Wright & Schulte LLC To Provide Information On Potential For Xarelto Bleeding Side Effects, Growing Litigation 4Health News:The Peripheral Neuropathy Program Review Exposes Randall Labrum's Peripheral Neuropathy Treatment Program – Vkool.com 2Health News:The Peripheral Neuropathy Program Review Exposes Randall Labrum's Peripheral Neuropathy Treatment Program – Vkool.com 3Health News:Discounted Red Evening Gown Announced by iFitDress.com 2
... Stanford University School of Medicine and the Veterans Affairs Palo ... of low weight new- born deaths between 1991 and ... babies would have survived if they had been born in ... regional medical centers. This would afford the best chance of ...
... two state-run medical college hospitals in West Bengal entered its ... ,The house staff and interns of the Chittaranjan ... protesting a mob fury in which the hospital premises were ... Riyazuddin, died. ,A group of people from Riyazuddin's ...
... State University held a prayer and yoga session during the ... friendship and a lot of learning together," said Kanchan Banerjee, ... after the event Saturday. ,It has been 17 ... ,More than 30 students sat barefoot and cross-legged and chanted ...
... Any army is trained to kill. But the US military ... saving life. No it is not turning pacifist, certainly ... them provide the much needed critical medical care on the ... ,Officials said medical care given immediately after injuries ...
... breast cancer at the University of Cambridge claim to have ... ,They made this breakthrough by using the ... of DNA simultaneously instead of one by one. ... programme in 12 to 15 years, in which the inherited ...
... second most widespread neurodegenerative cause of dementia . ... disease. Getting the accurate diagnosis is particularly important ... health symptoms of Alzheimer's disease can be potentially ... ,The study found that even prior ...
Cached Medicine News:Health News:Low Weight Newborns at Greater Risk in Community Hospitals 2Health News:Low Weight Newborns at Greater Risk in Community Hospitals 3Health News:US Soldiers to Be Trained in Critical Medical Care 2Health News:Scientists Identify Four Genes That Raise the Risk of Breast Cancer 2Health News:Personality Changes may Help to Identify a Form of Dementia 2
(Date:7/11/2014)... -- Neurelis, Inc. ("Neurelis") today announced an agreement with ... by Biotie to purchase Neurelis, clearing the way for ... for pediatric and adult epilepsy patients who experience acute ... has advanced the development program for NRL-1 and worked ... required for NDA submission to the FDA.  Given the ...
(Date:7/10/2014)... CARLSBAD, Calif. , July 10, 2014 /PRNewswire/ ... products and services, has launched the FreeRunner™ knee ... runners, who suffer from patella mal-tracking return to ... anatomy differently than other braces, providing support when ... move normally when they don,t. Patellofemoral ...
(Date:7/10/2014)... JORDAN, Utah , July 10, 2014  BC ... solutions, and MiE America , Inc., a leading ... have entered into a long-term agreement naming BC Technical ... the US. MiE and BC Technical ... strategic agreement to establish BC Technical as the service ...
Breaking Medicine Technology:Neurelis Regains Rights to Intranasal Diazepam Program 2Neurelis Regains Rights to Intranasal Diazepam Program 3Breg Introduces Knee Brace to Help Runners with Patellofemoral Pain Syndrome 2BC Technical Partners With MiE America To Be Authorized Provider Of Systems & Service 2
... Inc. today announced that it has been awarded a ... $600,000 from the National Institute of Allergy and Infectious ...  The grant will be used to demonstrate the feasibility ... platelet recovery and improve survival in a mouse model ...
... TOPEX, Inc. announces the sale of its skin cancer ... energy SRT 100 superficial radiotherapy treatment system. Since TOPEX ... operating worldwide at hospital radiation oncology centers, dermatology and ... The low energy superficial radiotherapy system provides patients an ...
Cached Medicine Technology:Bolder BioTechnology Announces $600,000 Grant from NIH to Study Long-Acting IL-11 Analog in Treating Acute Radiation Syndrome 2TOPEX Sells Skin Cancer Business Operations to SENSUS Healthcare 2
Auto Suture MULTIFIRE PREMIUM skin stapler Disposable Loading Unit is a single use premium multi fire DLU that is available in four sizes....
... Appose Single Use Skin Staple Remover ... extractor design that is packaged 12 ... to remove skin staples. , ... lower jaws of the extractor under ...
... PROXIMATE RH skin stapler is a ... head assembly., ,PROXIMATE RH has improved ... along with a ratchet mechanism for easier ... a sterile, single patient use instrument designed ...
... use, reloadable articulating (22° and 45° in ... handle for resection, transection and anastomosis for ... stapler places two triple-staggered rows of staples ... in between. The instrument is designed for ...
Medicine Products: