Navigation Links
Scripps Florida awarded $7.6 million grant to develop novel treatment for Parkinson's disease
Date:3/12/2008

cal pharmaceutical approach to drug development, which involves annual milestones and multiple compound tracking.

Our research plan is designed to mitigate the risk of developing a single compound that may fail due to specific problems, and to maximize the chance for clinical success by having back-up compounds, LoGrasso said. We believe that using this approach to optimize small-molecule inhibitors will create a series of compounds with favorable pharmacokinetic properties and safety profiles.

The scientists will examine small-molecule compounds that inhibit c-jun-N-terminal kinase 2/3 (JNK 2/3). Pronounced Junk, JNK 2/3 is an important contributor to stress-induced apoptosis (cell death) and has been shown to play a significant role in neuronal survival. As such, the kinase is a highly viable target for drugs to treat neurodegenerative disorders like Parkinsons disease.

Previous research has shown that small-molecule and peptide inhibitors of the JNK target protect dopaminergic neurons in both acute and chronic models of Parkinsons disease. Previous research has also shown that the JNK2/3 knockout mouse modelsmice that lack the gene for JNK2/3suffer fewer Parkinsons-like symptoms.

The scientists hope to identify approximately three compounds that demonstrate in vivo efficacy by the third year, and a top compound by year four of the research program.

When were finished, our aim it is to have a safe, efficacious compound with sufficient preclinical safety data to support human clinical studies, LoGrasso said.


'/>"/>

Contact: Keith McKeown
kmkeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scripps Research scientists shed new light on how antibodies fight HIV
2. Scripps Health Treats More Than 160 Fire Victims at Emergency Departments Across San Diego County
3. Scripps research scientists discover chemical triggers for aggression in mice
4. Scripps research scientists find new genetic mutation that halts the development of lupus
5. Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells
6. Scripps scientists peg wind as the force behind fish booms and busts
7. Scripps research scientists devise approach that stops HIV at earliest stage of infection
8. Owner and Operator of Florida Durable Medical Equipment Company Convicted of Medicare Fraud
9. PainCare Receives $14.4 Million in Cash From Completed Sale of South Florida Ambulatory Surgery Centers
10. Judge Rules That Florida Disease Management Program Serving 8,000 HIV/AIDS Patients Should Be Re-bid, Says AIDS Healthcare Foundation
11. Blue Cross and Blue Shield of Florida Reports Eighteenth Consecutive Year of Positive Performance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2015)... MN (PRWEB) April 25, 2015 On ... recipient of RFID Journal’s annual Best Implementation Award. ... has demonstrated the best use of RFID technology to ... winner is the company that best demonstrates how RFID ... was presented at RFID Journal Live! 2015 in San ...
(Date:4/24/2015)... York, NY (PRWEB) April 24, 2015 ... sober living residence in Westchester County. Just 35 miles ... help transition individuals back into everyday life while recovering ... Thursday, May 7, 2015, will allow therapists, doctors and ... areas and learn more about the opportunities offered by ...
(Date:4/24/2015)... Ryadon is a leading manufacturer of ... and services to complement any custom hardware requirements you ... will be offered on all heavy duty drawer slides ... 10% discount - Order 20+: Receive 20% discount , ... Products, Furniture ,Drawer Slides, ...
(Date:4/24/2015)... New York, New York (PRWEB) April 24, 2015 ... continue to move forward in the federal ... of South Carolina. According to court documents, the ... Status Report on April 16th detailing, among other ... The report notes that counsel for both plaintiffs ...
(Date:4/24/2015)... The first step to transforming one’s life ... meditation and yoga teacher Stine Koppernæs, meditation and changing ... that allow her to experience more peace and freedom ... teacher since 2006, and through the years she has ... , “I love sharing this way of finding true, ...
Breaking Medicine News(10 mins):Health News:Seeonic’s Industry Leading Technology Powers Interstate Batteries to Winning Award 2Health News:Constellations Recovery Opens The First Luxury Sober Living Residence in Westchester New York 2Health News:Constellations Recovery Opens The First Luxury Sober Living Residence in Westchester New York 3Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 2Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 3Health News:Federal Lipitor Lawsuits Progress, as New Status Report Details Preparation for Upcoming Bellwether Trials 2Health News:Federal Lipitor Lawsuits Progress, as New Status Report Details Preparation for Upcoming Bellwether Trials 3
... may be possible with many low energy treatments than ... ,The results of this study were published in ... eight participants over a three-month period during which they ... regeneration treatments are done to reduce wrinkles and for ...
... of 654 new cases of dengue fever were reported across ... average of 400 new //cases a day last week, Paraguay's ... Nicanor Duarte Frutos has not yet declared the epidemic to ... declaration. ,Dengue fever is a viral infection ...
... with a condition that is a strong genetic predictor ... genetic counseling or cancer screening. //According to a recent ... screening rates could be improved if physicians provided stronger ... screening to their patients. ,“We studied families with ...
... New Delhi: The eradication of neglected tropical diseases should ... the World Health Organization (WHO).// ,Many people ... leprosy, lymphatic filaria, leishmaniasis and yaws. Dengue is emerging ... ,"These diseases cause great suffering and ill-health and have ...
... - A new study by researchers from Queen's University ... eye movement tests in the diagnosis of fetal alcohol ... called FASD affects children when mothers have consumed alcohol ... tasks, could help effectively measure FASD in children, the ...
... approved meat and milk from cloned animals while it conducts ... its customers and consumers don't want milk from cloned animals. ... among dozens of other brands. ,"Numerous surveys ... products that contain milk from cloned cows and Dean Foods ...
Cached Medicine News:Health News:WHO Urges Higher Priority for Neglected Diseases 2Health News:Milk from Cloned Cows is Not Welcome at the Nation's Biggest Milk Company 2
(Date:4/24/2015)... EAST HANOVER, N.J. , April 24, 2015  Novartis ... diversity for the second year in a row on the ... the results of its 2015 Top 50 Companies for Diversity ... New York, NY . NPC also ranked second on ... on the Top 10 Companies for Employee Resource Groups list. ...
(Date:4/24/2015)... , April 24, 2015 /CNW/ - T-Bird Pharma ... focused on developing premium quality medical marijuana products and ... Marihuana for Medical Purposes Regulations ( Canada ... with certain of its shareholders, has closed the transaction ... ("Medna").  Medna has acquired (the "Escrow Transfer") a total ...
(Date:4/23/2015)... Ill. , April 24, 2015  AbbVie (NYSE: ... and Drug Administration (FDA) has accepted its New Drug ... all-oral, interferon-free, two direct-acting antiviral treatment of ombitasvir, paritaprevir, ... the treatment of adults with chronic genotype 4 (GT4) ... is the first all-oral, interferon-free therapy being evaluated by ...
Breaking Medicine Technology:Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 2Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 3Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 4T-Bird Pharma Inc. Announces Closing of Transaction with Medna Biosciences 2T-Bird Pharma Inc. Announces Closing of Transaction with Medna Biosciences 3U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 2U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 3U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 4U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 5U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 6U.S. FDA Grants Priority Review to AbbVie for Investigational, All-Oral, Interferon-Free Therapy for the Treatment of Genotype 4 Chronic Hepatitis C 7
... LAKES, N.J., Jan. 11 BD (Becton, Dickinson and Company) (NYSE: ... live webcast of its first fiscal quarter 2010 earnings conference call ... will issue a press release detailing the quarter,s earnings earlier that ... slides, will be accessible through BD,s website at www.bd.com/investors ...
... , WASHINGTON, Jan. ... that Major League Baseball star Aaron Boone is featured in ... public affairs television program that tells the compelling and inspirational stories of ... television stations nationwide. It is sponsored by the Pharmaceutical Research and ...
Cached Medicine Technology:BD Announces Live Webcast of First Fiscal Quarter Earnings Conference Call 2Major League Baseball Star Aaron Boone on 'Sharing Miracles' 2Major League Baseball Star Aaron Boone on 'Sharing Miracles' 3
... includes everything from the care package ... Spare Fluorescent Bulb, additional Vibratome Feather ... and a Specimen Tray. ... 1/2" speciment mounts, replacement rotating mounts, ...
... The Specimen Tray accessory fits inside the ... removable working area for tissue sectioning. Specimens ... specimen tray. This is a great option ... an expensive buffer, or wish to utilize the ...
... inside the existing black Vibratome bath. This ... buffer and ice kept in the original black ... has round mounting disks that can be easily ... bath surface are marked with degrees of rotation ...
... This unit provides a convenient reservoir of cooling ... operated for an extended period of time or in ... nearby to cool the hot side of the thermoelectric ... of water, which is adequate to run the 900R ...
Medicine Products: