Navigation Links
Scripps Florida awarded $7.6 million grant to develop novel treatment for Parkinson's disease
Date:3/12/2008

Philip LoGrasso, associate professor and senior director for drug discovery at Scripps Florida, will lead the project as principal investigator. LoGrasso, who joined Scripps Florida in 2005, previously held positions at Merck and the NIH.

The new five-year grant will fund research to develop a compound to treat neurodegeneration in Parkinsons disease. The goal of the project is to bring the potential treatment to the point where Scripps Research and potential partners can file an application for an investigational new drugthe first step in the lengthy clinical trials process required by the U.S. Food and Drug Administration.

An estimated one million Americans are believed to suffer from Parkinson's disease, according to the Parkinsons Disease Foundation; approximately 40,000 new cases are reported annually. Patients with Parkinsons suffer from a loss of dopaminergic neurons, the source of dopamine, a neurotransmitter that plays a key role in motor reflexes and cognitition. While some loss of dopaminergic neurons is common, Parkinsons patients routinely lose more than half.

Development of a drug that prevents dopaminergic neurodegeneration would be a quantum leap in the clinical treatment of Parkinsons disease, LoGrasso said. All current therapies treat only the symptoms of the disease, not the underlying pathologies. Current treatments also tend to lose therapeutic efficacy over time, or have adverse side effect profiles that make their long-term use difficult.

A Classic Approach

To develop the new small-molecule compound, LoGrasso will work with a team of Scripps Research scientists. Together, the team represents a range of experience in pharmaceutical preclinical drug development, encompassing the fields of medicinal chemistry, biochemistry, cell biology, structural biology, behavioral pharmacology, drug metabolism and pharmacokinetics, and toxicology.

The team will use what LoGrasso calls a classi
'/>"/>

Contact: Keith McKeown
kmkeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scripps Research scientists shed new light on how antibodies fight HIV
2. Scripps Health Treats More Than 160 Fire Victims at Emergency Departments Across San Diego County
3. Scripps research scientists discover chemical triggers for aggression in mice
4. Scripps research scientists find new genetic mutation that halts the development of lupus
5. Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells
6. Scripps scientists peg wind as the force behind fish booms and busts
7. Scripps research scientists devise approach that stops HIV at earliest stage of infection
8. Owner and Operator of Florida Durable Medical Equipment Company Convicted of Medicare Fraud
9. PainCare Receives $14.4 Million in Cash From Completed Sale of South Florida Ambulatory Surgery Centers
10. Judge Rules That Florida Disease Management Program Serving 8,000 HIV/AIDS Patients Should Be Re-bid, Says AIDS Healthcare Foundation
11. Blue Cross and Blue Shield of Florida Reports Eighteenth Consecutive Year of Positive Performance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... (PRWEB) August 20, 2014 Today, ... announced the publication of a new eBook, Affordable ... many small business owners feel uncertain about how ... family, and their bottom line. , The new ... and helps businesses navigate their upcoming health insurance ...
(Date:8/20/2014)... By Dennis Thompson ... -- U.S. teen birth rates fell dramatically during the past ... dollars, a new government report shows. An estimated 4 ... the decline, according to researchers from the U.S. Centers for ... "leapt out at me from the report," said Bill Albert, ...
(Date:8/20/2014)... study of chronic users of codeine-containing cough syrups ... brain white matter and associates these changes with ... used diffusuion tensor imaging (DTI) (an MR imaging ... white matter integrity of chronic CCS users. Deficits ... including the inferior fronto-occipital fasciculus, which other studies ...
(Date:8/20/2014)... WEDNESDAY, Aug. 20, 2014 (HealthDay News) -- Loss of ... help explain why many seniors have trouble falling and ... patients, sleep disruption can be especially severe and often ... researchers. The investigators analyzed data from the Rush ... who enrolled at age 65 and are being followed ...
(Date:8/20/2014)... 20, 2014 Park Cities Pet Sitter ... Presents 4 Pets supply donation drive that benefits the animal ... national campaign that coincides with the Humane Society of the ... 2nd through 8th, 2014. , As part of their participation, ... and monetary donations for the Presents 4 Pets drive from ...
Breaking Medicine News(10 mins):Health News:Teen Birth Rate Has Dropped Dramatically in Last Two Decades: CDC 2Health News:Teen Birth Rate Has Dropped Dramatically in Last Two Decades: CDC 3Health News:Seniors' Sleep Woes May Be Linked to Loss of Brain Cells 2Health News:Dallas-based Park Cities Pet Sitter Announces Participation in the 2014 National Association of Professional Pet Sitters “Presents 4 Pets” Program 2Health News:Dallas-based Park Cities Pet Sitter Announces Participation in the 2014 National Association of Professional Pet Sitters “Presents 4 Pets” Program 3Health News:Dallas-based Park Cities Pet Sitter Announces Participation in the 2014 National Association of Professional Pet Sitters “Presents 4 Pets” Program 4
... blood vessels open to treat heart disease are poorly ... Journal of Interventional Cardiology . A case report ... the Detroit Medical Center Cardiovascular Institute, and her colleagues ... the recently marketed Ion stent (Boston Scientific, Natick, MA) ...
... from the University of Sheffield has found that people are willing ... year, for greener urban spaces. Researchers surveyed the public in ... out how much extra they were willing to pay in council ... They found that people were willing to pay more for greener ...
... Young athletes who routinely take hits to the head could ... a concussion, according to the results of a new preliminary ... (URMC) said their findings could be a red flag for ... young people whose brains are still developing. The study ...
... HealthDay Reporter , WEDNESDAY, Nov. 16 (HealthDay News) ... is better at controlling a serious kidney complication from ... suggests. People taking mycophenolate were about half as ... taking azathioprine (Imuran), according to the researchers. "This ...
... 132,000 Internal medicine physician and medical student members of ... (D-PA) for urging the Joint Select Committee on Deficit ... PHYSICIAN PAYMENT INNOVATION ACT. This proposal repeals the ... better payment systems for physicians providing services to patients ...
... is the recipient of one of Canada,s top awards ... the mammalian immune system, Kubes will accept the 2011 ... Canadian Institutes of Health Research (CIHR) at a ceremony ... Kubes for winning this prestigious award," said the Honourable ...
Cached Medicine News:Health News:Public willing to pay more for greener urban spaces 2Health News:Public willing to pay more for greener urban spaces 3Health News:Routine Head Hits in Sports May Injure Brain, Experts Warn 2Health News:Newer Drug Seems Better at Controlling Lupus Kidney Complication 2Health News:Newer Drug Seems Better at Controlling Lupus Kidney Complication 3Health News:Internists 'applaud' Schwartz Proposal to prevent 'devastating' Medicare cuts 2Health News:University of Calgary researcher named Canada's Health Researcher of the Year 2Health News:University of Calgary researcher named Canada's Health Researcher of the Year 3
(Date:8/20/2014)... 20, 2014 Research and Markets ... "Global Biosimilars/Follow-on-Biologics Market (Technology, Types, Applications, Services and ... report to their offering. A ... and geography) - Size, Share, Global Trends, Company ... and Forecast, 2013 - 2020", suggests that the ...
(Date:8/20/2014)... , August 20, 2014 ... report titled "Monochloroacetic Acid (MCA) Market for Cellulosics, Agrochemicals, ... Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 ... at USD 817.1 million in 2013 and is anticipated ... a CAGR of 3.6% during the forecast period from ...
(Date:8/20/2014)... -- Research and Markets has announced ... Care and Closure Market (Types, Applications, End User ... Profiles, Demand, Insights, Analysis, Research, Report, Opportunities, Segmentation ... their offering. The new report ... (types, applications, end user and geography) - Size, ...
Breaking Medicine Technology:Global Biosimilars/Follow-on-Biologics Market (Technology, Types, Applications, Services and Geography) - Research Report, 2013 - 2020 2Global Monochloroacetic Acid (MCA) Market is Expected to Reach USD 1,046.7 million by 2020: Transparency Market Research 2Global Monochloroacetic Acid (MCA) Market is Expected to Reach USD 1,046.7 million by 2020: Transparency Market Research 3Global Monochloroacetic Acid (MCA) Market is Expected to Reach USD 1,046.7 million by 2020: Transparency Market Research 4Global Advanced Wound Care and Closure Market (Types, Applications, End User and Geography) - Forecast to 2020 2
... indicates that anti-inflammatory drugs may become a new tool ... leading global cause of death. In investigating a specific ... researchers used the Cardiochip, a gene analysis tool designed ... Center for Applied Genomics at The Children,s Hospital of ...
... March 14, 2012 OncoSec Medical Incorporated ... Medical System (OMS) ElectroOncology therapies to treat solid ... Institute in Santa Monica, CA, and Lakeland Comprehensive ... as enrolling sites, and investigators are screening patients ...
Cached Medicine Technology:Gene Chip, Invented by Children's Hospital of Philadelphia Scientist, Pinpoints New Target to Prevent Heart Disease 2Gene Chip, Invented by Children's Hospital of Philadelphia Scientist, Pinpoints New Target to Prevent Heart Disease 3OncoSec Initiates Two Additional Clinical Sites for Phase II Metastatic Melanoma Trial 2OncoSec Initiates Two Additional Clinical Sites for Phase II Metastatic Melanoma Trial 3OncoSec Initiates Two Additional Clinical Sites for Phase II Metastatic Melanoma Trial 4
... The 5mm AEM Laparoscopic Instruments incorporate a ... Instruments are shielded and monitored to prevent ... the instrument caused by insulation failure or ... The protective shield built into all AEM ...
SOLOS Endoscopy shares your commitment to provide every patient with the highest quality care available through our ongoing research and development of advanced surgical instruments and diagnostic so...
SOLOS Endoscopy shares your commitment to provide every patient with the highest quality care available through our ongoing research and development of advanced surgical instruments and diagnostic so...
... The Featured Products ... at Mediflex and are ... modular in regular or ... come equipped with insulation, ...
Medicine Products: