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Screening with low-dose spiral CT scanning reduces lung cancer deaths by 20 percent
Date:6/29/2011

about the imaging screenings and other clinical information, UCLA's Jonsson Comprehensive Cancer Center and a subset of NLST sites collected and banked specimens of blood, sputum, and urine at each of the three screening time points. Resected tumor tissues from lung cancer patients who underwent surgical resection were also collected across most sites. These specimens will provide a rich resource to validate molecular markers that may compliment imaging to detect early lung cancer, Aberle said.

More studies based on the NLST data set are ongoing, and will include reports on the cost effectiveness of spiral CT and the effects of the screening process on smoking behaviors over time.

The NLST was designed to answer specific questions about the screening in older heavy smokers and was conducted at sites with sophisticated medical resources and experts.

"The NLST cannot answer all of the important questions about screening that will be important for implementation," Aberle said. "However, the NLST data can be used to develop mathematical models to determine how long screening should be performed and how often. In addition, the data can be used to determine whether other groups at risk of lung cancer, such as light smokers, those with family histories of lung cancer or individuals with lung diseases like emphysema, would benefit from screening with spiral CT scanning."


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Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles Health Sciences
Source:Eurekalert

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