Navigation Links
Screening the herbal pharmacy
Date:3/4/2008

Curing cancer with natural products a case for shamans and herb women? Not at all, for many chemotherapies to fight cancer applied in modern medicine are natural products or were developed on the basis of natural substances. Thus, taxanes used in prostate and breast cancer treatment are made from yew trees. The popular periwinkle plant, which grows along the ground of many front yards, is the source of vinca alkaloids that are effective, for example, against malignant lymphomas. The modern anti-cancer drugs topotecan and irinotecan are derived from a constituent of the Chinese Happy Tree.

Looking for new compounds, doctors and scientists are increasingly focusing on substances from plants used in traditional medicine. About three quarters of the natural pharmaceutical compounds commonly used today are derived from plants of the traditional medicine of the people in various parts of the world. The chances of finding new substances with interesting working profiles in traditional medicinal plants are better than in common-or-garden botany.

In his search for active ingredients, Professor Dr. Thomas Efferth of the DKFZ has been concentrating on herbal remedies from traditional Chinese medicine with particularly well documented application range. Working together with colleagues in Mainz and Dsseldorf, Germany, Graz, Austria and Kunming in China, he launched a systematic compound search in 76 Chinese medicinal plants that are believed to be effective against malignant tumors and other growths. First results of this study have now been published.

Extracts from 18 of the plants under investigation were found to substantially suppress the growth of a cancer cell line in the culture dish. With this success rate of about 24 percent, we are way above the results that could be expected from searching through large chemical substance libraries, Thomas Efferth explains.

The scientists proceeded to chemically separate, step by step, all active extracts, tracing the active component after each separation step by cell tests. The chemical structure of the compounds is analyzed using nuclear magnetic resonance and mass spectroscopy. We are combining natural substance research with advanced analytical and molecular-biological methods, Efferth explains. Plant constituents that seem particularly promising are immediately subjected to further tests. Such constituents include, for example, substances derived from the Rangoon Creeper, an ornamental plant with red flowers, or from Red-Root Sage. The latter contains three ingredients with powerful anti-tumor activity. The substances were found to suppress the growth of a specific tumor cell line that is particularly resistant to many commonly used cytotoxins due to overproduction of a transport protein in the cell wall. In contrast, a whole range of standard anti-cancer drugs fail to be effective against this cell.

We can expect to find many interesting, yet unknown working mechanisms among the chemically highly diverse natural substances. Currently, we are aligning the effectiveness of the substances on 60 different cancer cell lines with the gene activity profiles of these cells. Thus, we can determine the exact gene products that are the cellular targets of our compounds. Thereby, it may be possible to discover whole new Achilles heels of the cancer cell, said Efferth describing the next steps.


'/>"/>

Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
49-622-142-2843
Helmholtz Association of German Research Centres
Source:Eurekalert

Related medicine news :

1. Task Force Recommends Against Screening for Chronic Obstructive Pulmonary Disease Using Spirometry
2. In Early Childhood, Continuous Care by One Doctor Improves Delivery of Health Screenings
3. In early childhood, continuous care by 1 doctor improves delivery of health screenings
4. Zebrafish provide useful screening tool for genes, drugs that protect against hearing loss
5. Newborn Screening Suggests Decline in Cystic Fibrosis
6. Microsoft Introduces Patient Safety Screening Tool to Stop Spread of In-Hospital Infections
7. 2008 Womens Heart Health Fair Offers Free Screenings, Advice for Baltimore Women
8. Free Health Screenings Aim to Identify Risk of Heart Disease in Women
9. Signalife & Athletes Foundation Complete Second Mobile Health Screening
10. Express Screening Process Aims to Put Diabetics on the Fast Track to Better Health
11. Appropriate medical screening for antimalarials vital to US military personnel
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... , ... May 27, 2016 , ... ... this installment is bolstered by inspiring human-interest stories, courtesy of awareness-driven celebrities and ... the industry, from leading advocates, associations and industry leaders such as Bioness. ...
(Date:5/27/2016)... , ... May 27, 2016 , ... Beleza Medspa ... body fat composition regulations. This is the first time that Coolsculpting is being ... at least every six months to ensure they meet the prescribed body-fat standard, measured ...
(Date:5/27/2016)... ... 2016 , ... Aimed at nurses and employees in the health care world, ... in the nursing and health care industry. It also provides insight to the developing ... , As the nursing industry is coming out of one of the biggest ...
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... ... trusted name in the pharmaceutical, medical and food industries. Aside from its GMP ... certification (SIC), providing proof of successfully certified products, services and staff. , Validation ...
(Date:5/26/2016)... ... ... There are many ways to cook a hot dog, but new research ... their dogs straight off the grill. Of the 90 percent of Americans who say ... a hot dog, far outpacing other cooking methods such as steaming (12 percent), microwaving ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... , May 27, 2016 ... instances of hypertension is driving ambulatory blood pressure monitoring ... their elasticity and their ability to respond to different ... This condition can lead to various cardiovascular disorders such ... vascular disease. These diseases are growing in prevalence each ...
(Date:5/27/2016)... Amarantus BioScience Holdings, Inc. (OTCQX: AMBS), ... Neurology and Orphan Diseases, today announced that President & CEO ... conferences: SeeThru Equity MicroCap Conference   ... City , NY When: Tuesday, May 31 st ... Where: Grand Hyatt Hotel, 109 East 42 nd ...
(Date:5/26/2016)... 2016 A key trend that ... emergence of new treatments. Cardax, a development stage life ... The therapy is expected to fulfil large unmet medical ... conducting studies to develop new treatments for osteoarthritis. One ... involved in osteoarthritis are being investigated, and early trials ...
Breaking Medicine Technology: