Navigation Links
Screening the herbal pharmacy
Date:3/4/2008

Curing cancer with natural products a case for shamans and herb women? Not at all, for many chemotherapies to fight cancer applied in modern medicine are natural products or were developed on the basis of natural substances. Thus, taxanes used in prostate and breast cancer treatment are made from yew trees. The popular periwinkle plant, which grows along the ground of many front yards, is the source of vinca alkaloids that are effective, for example, against malignant lymphomas. The modern anti-cancer drugs topotecan and irinotecan are derived from a constituent of the Chinese Happy Tree.

Looking for new compounds, doctors and scientists are increasingly focusing on substances from plants used in traditional medicine. About three quarters of the natural pharmaceutical compounds commonly used today are derived from plants of the traditional medicine of the people in various parts of the world. The chances of finding new substances with interesting working profiles in traditional medicinal plants are better than in common-or-garden botany.

In his search for active ingredients, Professor Dr. Thomas Efferth of the DKFZ has been concentrating on herbal remedies from traditional Chinese medicine with particularly well documented application range. Working together with colleagues in Mainz and Dsseldorf, Germany, Graz, Austria and Kunming in China, he launched a systematic compound search in 76 Chinese medicinal plants that are believed to be effective against malignant tumors and other growths. First results of this study have now been published.

Extracts from 18 of the plants under investigation were found to substantially suppress the growth of a cancer cell line in the culture dish. With this success rate of about 24 percent, we are way above the results that could be expected from searching through large chemical substance libraries, Thomas Efferth explains.

The scientists proceeded to chemically separate, step by step, all active extracts, tracing the active component after each separation step by cell tests. The chemical structure of the compounds is analyzed using nuclear magnetic resonance and mass spectroscopy. We are combining natural substance research with advanced analytical and molecular-biological methods, Efferth explains. Plant constituents that seem particularly promising are immediately subjected to further tests. Such constituents include, for example, substances derived from the Rangoon Creeper, an ornamental plant with red flowers, or from Red-Root Sage. The latter contains three ingredients with powerful anti-tumor activity. The substances were found to suppress the growth of a specific tumor cell line that is particularly resistant to many commonly used cytotoxins due to overproduction of a transport protein in the cell wall. In contrast, a whole range of standard anti-cancer drugs fail to be effective against this cell.

We can expect to find many interesting, yet unknown working mechanisms among the chemically highly diverse natural substances. Currently, we are aligning the effectiveness of the substances on 60 different cancer cell lines with the gene activity profiles of these cells. Thus, we can determine the exact gene products that are the cellular targets of our compounds. Thereby, it may be possible to discover whole new Achilles heels of the cancer cell, said Efferth describing the next steps.


'/>"/>

Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
49-622-142-2843
Helmholtz Association of German Research Centres
Source:Eurekalert

Related medicine news :

1. Task Force Recommends Against Screening for Chronic Obstructive Pulmonary Disease Using Spirometry
2. In Early Childhood, Continuous Care by One Doctor Improves Delivery of Health Screenings
3. In early childhood, continuous care by 1 doctor improves delivery of health screenings
4. Zebrafish provide useful screening tool for genes, drugs that protect against hearing loss
5. Newborn Screening Suggests Decline in Cystic Fibrosis
6. Microsoft Introduces Patient Safety Screening Tool to Stop Spread of In-Hospital Infections
7. 2008 Womens Heart Health Fair Offers Free Screenings, Advice for Baltimore Women
8. Free Health Screenings Aim to Identify Risk of Heart Disease in Women
9. Signalife & Athletes Foundation Complete Second Mobile Health Screening
10. Express Screening Process Aims to Put Diabetics on the Fast Track to Better Health
11. Appropriate medical screening for antimalarials vital to US military personnel
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... ... Clinical Conductor CTMS, which provides a modern CTMS workflow designed to seamlessly integrate ... information has been condensed to a single page, maximizing usability and improving efficiency ...
(Date:1/19/2017)... ... January 19, 2017 , ... Workrite ... system. , The Tranquility privacy panel system was designed to deliver the ... panels help reduce noise and provide the visual privacy required to maintain concentration ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... and financial planning services to communities throughout eastern Georgia, is embarking on a ... disease. , Heart disease kills more Americans every year than anything else, yet ...
(Date:1/19/2017)... ... January 19, 2017 , ... Attorney Robert “RC” Pate ... year donated money to the Triumph Over Kid Cancer foundation. Each year, 175,000 children ... those children. James saw firsthand the effect of the critical funding gap for research ...
(Date:1/19/2017)... ... January 19, 2017 , ... Bill Howe Plumbing, Heating & Air in ... Association; “Howe” Healthy is Your Heart Drawing Contest The drawing contest asks ... Bill Howe Plumbing, Heating & Air receives over 600 entries. The culmination of the ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... Conference Call and Webcast to Follow Vanda ... will release results for the fourth quarter of 2016 on Wednesday, ... ... at 4:30 PM ET on Wednesday, February 15, 2017, during which ... results and other corporate activities. To participate in the conference call, ...
(Date:1/19/2017)... Jan. 19, 2017  Stealth BioTherapeutics Inc. ( Stealth ... mitochondrial dysfunction, today announced new additions to its senior ... Chief Medical Officer, and Daniel Geffken as ... Jim Carr , Pharm.D. has been promoted to ... pleased to welcome Doug and Daniel to our management ...
(Date:1/19/2017)... 2017  Abaxis, Inc. (NasdaqGS: ABAX ), ... and consumables for the medical and veterinary markets worldwide, ... results for the third quarter fiscal year 2017, ended ... p.m. ET on Thursday, January 26, 2017.  The Company ... year 2017 after the market closes on Thursday, January ...
Breaking Medicine Technology: