Navigation Links
Screening the herbal pharmacy
Date:3/4/2008

Curing cancer with natural products a case for shamans and herb women? Not at all, for many chemotherapies to fight cancer applied in modern medicine are natural products or were developed on the basis of natural substances. Thus, taxanes used in prostate and breast cancer treatment are made from yew trees. The popular periwinkle plant, which grows along the ground of many front yards, is the source of vinca alkaloids that are effective, for example, against malignant lymphomas. The modern anti-cancer drugs topotecan and irinotecan are derived from a constituent of the Chinese Happy Tree.

Looking for new compounds, doctors and scientists are increasingly focusing on substances from plants used in traditional medicine. About three quarters of the natural pharmaceutical compounds commonly used today are derived from plants of the traditional medicine of the people in various parts of the world. The chances of finding new substances with interesting working profiles in traditional medicinal plants are better than in common-or-garden botany.

In his search for active ingredients, Professor Dr. Thomas Efferth of the DKFZ has been concentrating on herbal remedies from traditional Chinese medicine with particularly well documented application range. Working together with colleagues in Mainz and Dsseldorf, Germany, Graz, Austria and Kunming in China, he launched a systematic compound search in 76 Chinese medicinal plants that are believed to be effective against malignant tumors and other growths. First results of this study have now been published.

Extracts from 18 of the plants under investigation were found to substantially suppress the growth of a cancer cell line in the culture dish. With this success rate of about 24 percent, we are way above the results that could be expected from searching through large chemical substance libraries, Thomas Efferth explains.

The scientists proceeded to chemically separate, step by step, all active extracts, tracing the active component after each separation step by cell tests. The chemical structure of the compounds is analyzed using nuclear magnetic resonance and mass spectroscopy. We are combining natural substance research with advanced analytical and molecular-biological methods, Efferth explains. Plant constituents that seem particularly promising are immediately subjected to further tests. Such constituents include, for example, substances derived from the Rangoon Creeper, an ornamental plant with red flowers, or from Red-Root Sage. The latter contains three ingredients with powerful anti-tumor activity. The substances were found to suppress the growth of a specific tumor cell line that is particularly resistant to many commonly used cytotoxins due to overproduction of a transport protein in the cell wall. In contrast, a whole range of standard anti-cancer drugs fail to be effective against this cell.

We can expect to find many interesting, yet unknown working mechanisms among the chemically highly diverse natural substances. Currently, we are aligning the effectiveness of the substances on 60 different cancer cell lines with the gene activity profiles of these cells. Thus, we can determine the exact gene products that are the cellular targets of our compounds. Thereby, it may be possible to discover whole new Achilles heels of the cancer cell, said Efferth describing the next steps.


'/>"/>

Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
49-622-142-2843
Helmholtz Association of German Research Centres
Source:Eurekalert

Related medicine news :

1. Task Force Recommends Against Screening for Chronic Obstructive Pulmonary Disease Using Spirometry
2. In Early Childhood, Continuous Care by One Doctor Improves Delivery of Health Screenings
3. In early childhood, continuous care by 1 doctor improves delivery of health screenings
4. Zebrafish provide useful screening tool for genes, drugs that protect against hearing loss
5. Newborn Screening Suggests Decline in Cystic Fibrosis
6. Microsoft Introduces Patient Safety Screening Tool to Stop Spread of In-Hospital Infections
7. 2008 Womens Heart Health Fair Offers Free Screenings, Advice for Baltimore Women
8. Free Health Screenings Aim to Identify Risk of Heart Disease in Women
9. Signalife & Athletes Foundation Complete Second Mobile Health Screening
10. Express Screening Process Aims to Put Diabetics on the Fast Track to Better Health
11. Appropriate medical screening for antimalarials vital to US military personnel
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... February 12, 2016 , ... Basketball is a game ... part of the Peety PoppersTM series, sign language translation is featured in the top ... and wellness in Peety PoppersTM lessons has a sign language translator to teach kids ...
(Date:2/12/2016)... Phoenix, AZ (PRWEB) , ... February 12, 2016 , ... ... Health Arizona General Hospital Emergency Room –Mesa. The new facility is licensed under ... Valley. , “Dr. Bingham is an excellent leader and will ensure our new ...
(Date:2/11/2016)... ... February 11, 2016 , ... According to an ... marketed as a weight loss dietary supplement, is being recalled due to the discovery ... Physicians, because there is not a single supplement on the market proven to help ...
(Date:2/11/2016)... ... ... Registered nurses, licensed practical nurses and nursing aides who treat stroke patients ... to Heal” on Thursday, February 25 from 9:00 to 11:00 a.m. at the ... of ANSA Consultants, who will discuss clinical best practices throughout the continuum of stroke ...
(Date:2/11/2016)... ... 12, 2016 , ... The Journal of Pain Research has seen ... SJR uses data taken from the Scopus database (Elsevier B.V.) and is a measure ... by the journal over a three year period and also the importance of the ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... PORTLAND, Ore. , Feb. 11, 2016 /PRNewswire/ ... pleased to announce the acquisition of SolutionsRx, a full-service ... access hospitals. Along with providing traditional contract pharmacy services, ... to assist clients in navigating the complex 340B regulatory ... of Wellpartner. --> James R. Love , ...
(Date:2/11/2016)... ROLLING MEADOWS , Ill. and INDIANAPOLIS ... major milestone for many young people, but for those ... demanding. Not only do these students juggle class schedules, ... challenges of living with type 1 diabetes. On top ... the first time. Diabetes Scholars Foundation ...
(Date:2/11/2016)... Jeffrey Zucker , vice president of Feasibility ... this year,s Summit for Clinical Operations Executives (SCOPE), being held ... FL. Zucker will discuss how sponsors can rebuild ... "Improving Site Study Activation and Performance" portion of the conference. ... 11:05 a.m. --> --> ...
Breaking Medicine Technology: