Navigation Links
Screening for transformed human mesenchymal stromal cells with tumorigenic potential
Date:1/29/2014

Researchers at Erasmus University Medical Center Rotterdam, The Netherlands, led by Dr. Qiuwei Pan and Dr. Luc van der Laan, have discovered that spontaneous tumorigenic transformation of human mesenchymal stem/stromal cells (MSCs) can occur during cell culture expansion, although the frequency is relatively low and often only observed after extensive passage in culture. This report appears in the January 2014 issue of Experimental Biology and Medicine.

Currently, MSCs are being widely investigated as a potential treatment for various diseases. According to ClinicalTrials.gov, over 350 clinical trials using MSCs have been registered by the end of 2013 (with a search of: mesenchymal stem cells). For cell transplantation, MSCs are often isolated from either the patient or from a third party donor, and then expanded in cell culture before therapeutic application. In fact, spontaneous transformation of primary cells in cell culture has been well-investigated over decades. Malignant transformation of murine and monkey MSCs has also recently been reported.

The current study confirmed that spontaneous tumorigenic transformation of human MSCs can occur during cell culture expansion. This potentially has large implications for the clinical application of ex vivo expanded MSCs. "Although this transformation is rare, we do need to carefully examine the presence of these aberrant cells in MSC cultures, before transplanting into patients", stresses the first author Dr. Pan. "We now have identified RNA molecule signatures that can be applied as a potential biomarker for the detection of these dangerous cells in long-term cultures", said senior author Dr. van der Laan. "However, further research is required to validate this biomarker in clinical grade cultures of MSCs that are used in clinical trials".

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said "This study provides a possible method for testing the safety of expanded adult stem cells. We look forward to the validation of these RNA biomarkers".


'/>"/>

Contact: Dr. Qiuwei Pan
q.pan@erasmusmc.nl
Society for Experimental Biology and Medicine
Source:Eurekalert

Related medicine news :

1. Autism Speaks study finds advances towards universal early screening
2. New study examines patterns of cancer screening in Appalachian women
3. Screening helps prevent cervical cancer in older women
4. Regenstrief and IU review finds lack of delirium screening in the emergency department
5. Increased risk of prostate cancer in African-American men; implications for PSA screening
6. PreCheck, Inc. Offers Human Resources Background Screening Training Webinar
7. Innovative Screening Strategy Swiftly Uncovers New Drug Candidates, New Biology
8. How Can University Educators Help Children's Vision? Katie Johnson Works with Graduate Students in Interactive Media and Design to Develop Vision Screening Tool
9. USAFact’s New RapidFACT Screening Platform Will Launch with Multiple Website Facelifts Tied to Both Old and New Products
10. New screening strategy to prevent cardiovascular complications in sports
11. Probability of Lung Cancer Overdiagnosis with LDCT Screening Addressed Using NLST Data
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2017)... ... July 21, 2017 , ... ... financial consultation services to families and business owners in the Dalton region, is ... support for children overcoming sexual assault and physical abuse. , The GreenHouse is ...
(Date:7/21/2017)... ... July 21, 2017 , ... Adolfson ... renovate and improve the Ramsey County Medical Examiners Facility located in Saint Paul, ... $2.5 million project is scheduled to start in late 2017/early 2018. , ...
(Date:7/21/2017)... ... July 21, 2017 , ... The Margarian Law Firm ... the contents of its ginger ale for allegedly containing no ginger. Dr. Pepper produces ... Snapple Group, Inc., plaintiff Gegham Margaryan alleges Canada Dry Ginger Ale claims on its ...
(Date:7/21/2017)... ... July 21, 2017 , ... Sharon ... the signature product of her research center at Bio-Logic Aqua Research® Water Life ... and the greatest number of sufferers of blindness. “We think that Nature’s Tears® ...
(Date:7/20/2017)... ... July 20, 2017 , ... TransPixel Volume 2 is ... clips in the FCPX timeline. This effect isolates horizontal and vertical lines of pixels ... contains either a rotating or flipping animation and can be changed using a drop-down ...
Breaking Medicine News(10 mins):
(Date:7/21/2017)... , July 21, 2017  Endo International plc ... completing a comprehensive review of its manufacturing network, the ... and distribution facilities in Huntsville, Alabama ... take place over the next 12 to 18 months. ... impacted by declining volumes of commoditized products and these ...
(Date:7/20/2017)... PAUL, Minn. , July 20, 2017  Prime Therapeutics ... Jonathan Gavras , M.D., following today,s Institute for Clinical ... report on the effectiveness and value of abuse-deterrent ... manager on the policy roundtable at the meeting. ... is not a material cost benefit to the use of ...
(Date:7/17/2017)... 17, 2017  MedX Holdings, Inc., the manufacturer and ... and rehabilitation equipment, today announced the national roll out ... considered the gold standard for the treatment of low ... strengthening equipment. How ... physician or practice who prescribe the MedX Home Back ...
Breaking Medicine Technology: