Navigation Links
Screening for breast cancer without X-rays: Lasers and sound merge in promising diagnostic technique
Date:5/7/2012

WASHINGTON, May 7X-ray mammography is an important diagnostic tool in the fight against breast cancer, but it has certain drawbacks that limit its effectiveness. For example, it can give in false positive and negative results; it also exposes women to low doses of ionizing radiation, which while accepted as safe still carry some risk.

In the first phase of clinical testing of a new imaging device, researchers from Netherlands' University of Twente and Medisch Spectrum Twente Hospital in Oldenzaal used photoacoustics light-induced sound rather than ionizing radiation to detect and visualize breast tumors. The team's preliminary results, which were conducted on 12 patients with diagnosed malignancies and reported today in the Optical Society's (OSA (http://www.osa.org)) open-access journal Optics Express (http://www.opticsinfobase.org/oe), provide proof-of-concept support that the technology can distinguish malignant tissue by providing high-contrast images of tumors.

"While we're very early in the development of this new technology, it is promising. Our hope is that these early results will one day lead to the development of a safe, comfortable, and accurate alternative or adjunct to conventional techniques for detecting breast tumors," explained researcher Michelle Heijblom, a Ph.D. student at the University of Twente.

Photoacoustics, a hybrid optical and acoustical imaging technique, builds on the established technology of using red and infrared light to image tissue and detect tumors. This technology, called optical mammography, reveals malignancies because blood hemoglobin readily absorbs the longer, redder wavelengths of light, which reveals a clear contrast between blood-vessel dense tumor areas and normal vessel environments. However, it is difficult to target the specific area to be imaged with this approach.

As a means of improving this, the researchers combined the light-based system's ability to distinguish between benign and malignant tissue with ultrasound to achieve superior targeting ability. The result of their refinements is a specialized instrument, the Twente Photoacoustic Mammoscope (PAM), which was first tested in 2007.

The device is built into a hospital bed, where the patient lies prone and positions her breast for imaging. Laser light at a wavelength of 1,064 nanometers scans the breast. Because there is increased absorption of the light in malignant tissue the temperature slightly increases. With the rise in temperature, thermal expansion creates a pressure wave, which is detected by an ultrasound detector placed on one side of the breast. The resulting photoacoustic signals are then processed by the PAM system and reconstructed into images. These images reveal abnormal areas of high intensity (tumor tissue) as compared to areas of low intensity (benign tissue). This is one of the first times that the technique has been tested on breast cancer patients.

By comparing the photoacoustic data with conventional diagnostic X-rays, ultrasound imaging, MRI, and tissue exams, the researchers showed that malignancies produced a distinct photoacoustic signal that is potentially clinically useful for making a diagnosis of breast cancer. The team also observed that the photoacoustic contrast of the malignant tissue is higher than the contrast provided by the conventional X-ray mammographies.

In looking to the future, notes Heijblom, "PAM needs some technical improvements before it is a really valuable clinical tool for diagnosis or treatment of breast cancer. Our next step is to make those improvements and then evaluate less obvious potential tumors, benign lesions, and normal breasts with it."


'/>"/>
Contact: Sarah Cogan
scogan@osa.org
202-416-1409
Optical Society of America
Source:Eurekalert  

Related medicine news :

1. CVS/pharmacy Begins Free Health Screenings in Communities Nationwide Through A Su Salud Program
2. New screening system for hepatitis C
3. News brief: Benefit of HPV Vaccination, Frequent Screening for Women over 41 is Likely to be Low
4. Diabetics Twice as Likely to Have Hearing Loss; Florida HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March
5. Diabetics Twice as Likely to Have Hearing Loss; Massachusetts HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March
6. Life Line Screening Joins Center for Health Transformation
7. EarthTrade Water to Hold a Private Screening of Tapped - The Movie: The Truth About Bottled Water Revealed During ExpoWest
8. Breast cancer screening: No added value through mammography
9. Researchers find that sociodemographic characteristics are related to a patients willingness to participate in cancer screenings
10. Blood Draw Dilemma: New Summit Health Article Helps Employers Choose the Best Screening Method
11. New Prostate Cancer Screening Guidelines Unveiled
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Screening for breast cancer without X-rays: Lasers and sound merge in promising diagnostic technique
(Date:5/28/2016)... ... May 28, 2016 , ... May 26, 2016- In ... Arts Fighting Challenge with theme event of “K Warriors” on June 4, 2016 at ... , The event is sponsored and hosted by Shaolin Institute and sanctioned by ...
(Date:5/27/2016)... , ... May 27, 2016 , ... Two director-level employees ... YWCA Tribute to Women and Industry (TWIN) 2016 honorees. The award recognizes businesswomen ... For this year, Geri Boone, Director of the MLTSS (Managed Long-Term Services and Supports) ...
(Date:5/27/2016)... NY (PRWEB) , ... May 27, 2016 , ... ... casual readers, this installment is bolstered by inspiring human-interest stories, courtesy of awareness-driven ... tech within the industry, from leading advocates, associations and industry leaders such as ...
(Date:5/27/2016)... ... May 27, 2016 , ... ... students studying complementary medicine. Allison Outerbridge is this year’s Life University ... May 18 at the university’s Student Leadership Awards ceremony. , Outerbridge is approaching ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cabot Corporation, Pfizer, ... respirators, according to court documents and SEC filings. A jury has returned ... v. American Optical Corporation, Case No. BC588866, Los Angeles County, California. The jury ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... 27, 2016 Kitov ... focused on late-stage drug development, today announced the ... of pivotal batches required for registration of KIT-302 ... This follows Kitov,s announcement in December ... met its primary efficacy endpoint. "We ...
(Date:5/26/2016)... 2016 TARE (Transarterial Radio-embolization) ... Savings and Overall Decreased Use of Hospital ... international specialist healthcare company, has today announced the ... Meeting of ISPOR (International Society for Pharmacoeconomics and ... (HCC) using yttrium-90 glass microspheres is associated with ...
(Date:5/25/2016)... HILDEN , Deutschland und GERMANTOWN, ... Zusammenarbeit mit Therawis bedient ... Entscheidungen bei Brustkrebs   QIAGEN N.V. ... QIA) gab heute bekannt, eine Lizenz- und Entwicklungsvereinbarung ... prädiktiver Assays für die Onkologie eingegangen zu sein. ...
Breaking Medicine Technology: