Navigation Links
Screening for Spinal Muscular Atrophy Not Cost-Effective: Study
Date:2/5/2010

But testing of high-risk couples could be viable, researchers say

FRIDAY, Feb. 5 (HealthDay News) -- It's not cost-effective to screen couples genetically to determine if they're at risk of having children with spinal muscular atrophy (SMA), says a U.S. study.

There is ongoing controversy about whether screening for SMA -- the most common genetic cause of infant death -- should be routinely offered to couples.

In this study, researchers created an analytical model to compare a policy of universal SMA screening to that of no screening. Baseline assumptions used in the model included a disease prevalence of 1 in 10,000 for a carrier rate of 1 in 50, 70 percent of affected children having severe disease.

The researchers also assumed a 90 percent sensitivity rate from carrier screening and that 2 percent of SMA cases arise from de novo mutations (genetic mutations not inherited from either parent).

The baseline cost estimates in 2009 dollars included $400 for a carrier screen and $260,000 for the lifetime cost of a child with severe disease. The researchers calculated maternal quality-adjusted-life-years assuming a 22 percent reduction in quality of life for having a child with severe SMA and 8 percent for fetal loss.

The researchers concluded that 11,000 women would have to be screened to prevent one case of SMA, at a cost of $4.7 million per case averted.

"Our findings show that screening everyone for SMA is not cost effective," study co-author Dr. Sarah Little, of Massachusetts General Hospital, said in a news release. "Our results, however, were most sensitive to changes in the baseline prevalence of disease, suggesting that prenatal SMA screening may be cost effective in high risk populations, such as those with a family history of disease."

The study was to be presented Friday at the annual meeting of the Society for Maternal-Fetal Medicine in Chicago.

More information

The Muscular Dystrophy Association has more about spinal muscular atrophy.



-- Robert Preidt



SOURCE: Society for Maternal-Fetal Medicine, news release, Feb. 5, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. FDA Approves New Roche West Nile Virus Blood Screening Test
2. New lung cancer guidelines oppose general CT screening
3. New Lung Cancer Guidelines Oppose General CT Screening
4. Lung Cancer Alliance Stands Behind CT Screening for Lung Cancer
5. Screening Proposed for Childhood Cholesterol Levels
6. A new technology for cancer screening listens for the signs of cancer
7. Study Questions Genetic Screening for Treatable Diseases
8. Cervical cancer screening: Too many are left unprotected
9. Simple, personalized interventions improve colorectal cancer screening rates
10. Doctors Office Outreach Boosts Colon Cancer Screening
11. Jefferson researchers find personalized interventions key to improving colon cancer screening rates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2017)... ... ... Plastic Surgery Associates is excited to announce that Heather Furnas, MD, and ... Meeting. Held in San Diego, at the San Diego Convention Center, the annual event ... to the Premier Global Hot Topics session, speaking on genital rejuvenation. , Hosted by ...
(Date:4/26/2017)... ... April 26, 2017 , ... Journal of Oral Implantology ... have severe consequences to overall dental health, including complications with speech, eating, and overcompensation ... dental implants to replace lost teeth. As the number of tooth replacements increase, it ...
(Date:4/26/2017)... Aviv, Israel (PRWEB) , ... April 26, 2017 , ... ... today announced a new partnership with Med-e-Mass , the largest Electronic Medical Records ... enable Med-e-Mass to link care plan incentives to a patient’s remote health progress, empowering ...
(Date:4/26/2017)... ... ... Infertility may be a result of an underlying pelvic ... become pregnant upon treating their diagnosis. , To properly diagnose patients, ... can provide the necessary information to diagnose and treat your problem. , ...
(Date:4/26/2017)... ... April 26, 2017 , ... Want to ... website ( CRISPRCas.pioneer.com ) that demonstrates how this advanced plant breeding technology is ... better food, with fewer resources. It highlights the business’ principles, research and collaboration ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... 2017 Research and Markets has ... and Market Prospects: Addressing Production Complexities Through Risk Management ... ... Biosimilar Pipeline and Market Prospects: Overcoming Production Complexities Through ... assessment of the current trends in the global biosimilars ...
(Date:4/20/2017)... April 20, 2017  CVS Pharmacy, the retail ... a new store design to enhance the retail ... food, health-focused products and expanded beauty selections paired ... customers discover new offerings. Together with its innovative ... of the customer experience at CVS Pharmacy.  ...
(Date:4/20/2017)... Research and Markets has announced the addition of the ... Outlook, Growth Trends, Key Players, Competitive Strategies and Forecasts, 2014 ... ... US$ 7,167.6 Mn in 2015, and is expected to reach ... 5.6% from 2016 to 2024. The global ...
Breaking Medicine Technology: