Navigation Links
Screening for Spinal Muscular Atrophy Not Cost-Effective: Study

But testing of high-risk couples could be viable, researchers say

FRIDAY, Feb. 5 (HealthDay News) -- It's not cost-effective to screen couples genetically to determine if they're at risk of having children with spinal muscular atrophy (SMA), says a U.S. study.

There is ongoing controversy about whether screening for SMA -- the most common genetic cause of infant death -- should be routinely offered to couples.

In this study, researchers created an analytical model to compare a policy of universal SMA screening to that of no screening. Baseline assumptions used in the model included a disease prevalence of 1 in 10,000 for a carrier rate of 1 in 50, 70 percent of affected children having severe disease.

The researchers also assumed a 90 percent sensitivity rate from carrier screening and that 2 percent of SMA cases arise from de novo mutations (genetic mutations not inherited from either parent).

The baseline cost estimates in 2009 dollars included $400 for a carrier screen and $260,000 for the lifetime cost of a child with severe disease. The researchers calculated maternal quality-adjusted-life-years assuming a 22 percent reduction in quality of life for having a child with severe SMA and 8 percent for fetal loss.

The researchers concluded that 11,000 women would have to be screened to prevent one case of SMA, at a cost of $4.7 million per case averted.

"Our findings show that screening everyone for SMA is not cost effective," study co-author Dr. Sarah Little, of Massachusetts General Hospital, said in a news release. "Our results, however, were most sensitive to changes in the baseline prevalence of disease, suggesting that prenatal SMA screening may be cost effective in high risk populations, such as those with a family history of disease."

The study was to be presented Friday at the annual meeting of the Society for Maternal-Fetal Medicine in Chicago.

More information

The Muscular Dystrophy Association has more about spinal muscular atrophy.

-- Robert Preidt

SOURCE: Society for Maternal-Fetal Medicine, news release, Feb. 5, 2010

Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. FDA Approves New Roche West Nile Virus Blood Screening Test
2. New lung cancer guidelines oppose general CT screening
3. New Lung Cancer Guidelines Oppose General CT Screening
4. Lung Cancer Alliance Stands Behind CT Screening for Lung Cancer
5. Screening Proposed for Childhood Cholesterol Levels
6. A new technology for cancer screening listens for the signs of cancer
7. Study Questions Genetic Screening for Treatable Diseases
8. Cervical cancer screening: Too many are left unprotected
9. Simple, personalized interventions improve colorectal cancer screening rates
10. Doctors Office Outreach Boosts Colon Cancer Screening
11. Jefferson researchers find personalized interventions key to improving colon cancer screening rates
Post Your Comments:
(Date:10/13/2015)... , ... October 13, 2015 , ... ... celebrating the opening of the Integrative Biosciences Center (IBio), a $93 million facility ... A grand opening celebration will be held at 10:30 a.m. Wednesday, Oct. 14, ...
(Date:10/13/2015)... ... October 14, 2015 , ... The ... of needle-placement technique in radiofrequency ablation for treatment of lumbar facet arthropathy ”. ... in nature, highlights the importance of anatomically correct needle placement technique for lumbar ...
(Date:10/13/2015)... ... October 13, 2015 , ... The Lymphoma Research Foundation (LRF) ... and serving the lymphoma community through a comprehensive series of education programs, outreach ... A Commitment to Cure last night at the Mandarin Oriental in New York ...
(Date:10/13/2015)... ... 13, 2015 , ... “Women have 2 questions when they find out they ... second is, “Will I lose my hair?’” , Carly Klein is the Founder of ... medical professionals to develop personalized hair loss treatment plans. With 10 years’ experience in ...
(Date:10/13/2015)... ... October 13, 2015 , ... Though trick-or-treating remains ... confines of their home. Whether it's making fun pre or post trick-or-treat snacks ... Florida Dairy Farmers. , Recipe 1: Green Chile Queso Dip with Sriacha ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... , October 14, 2015 ... The Global Nocturia Clinical Trials Review, H2, ... of worldwide Nocturia scenario, top line data ... as information on companies and institutes involved. ... . --> ...
(Date:10/13/2015)... NEW YORK , Oct. 13, 2015 ... been filed against Amicus Therapeutics, Inc. ("Amicus" or the ... action, filed in United States District Court, District of ... of a class consisting of all persons or entities ... October 1, 2015 inclusive (the "Class Period"). This class action ...
(Date:10/13/2015)... 13, 2015  The Alliance for Safe Biologic ... survey of 401 U.S. pharmacists showing strong support for ... for more transparency in labeling. Michael Reilly ... "This survey reinforces what ASBM has been hearing ... it clear that they prefer distinguishable names and more ...
Breaking Medicine Technology: