Navigation Links
Screening for Spinal Muscular Atrophy Not Cost-Effective: Study
Date:2/5/2010

But testing of high-risk couples could be viable, researchers say

FRIDAY, Feb. 5 (HealthDay News) -- It's not cost-effective to screen couples genetically to determine if they're at risk of having children with spinal muscular atrophy (SMA), says a U.S. study.

There is ongoing controversy about whether screening for SMA -- the most common genetic cause of infant death -- should be routinely offered to couples.

In this study, researchers created an analytical model to compare a policy of universal SMA screening to that of no screening. Baseline assumptions used in the model included a disease prevalence of 1 in 10,000 for a carrier rate of 1 in 50, 70 percent of affected children having severe disease.

The researchers also assumed a 90 percent sensitivity rate from carrier screening and that 2 percent of SMA cases arise from de novo mutations (genetic mutations not inherited from either parent).

The baseline cost estimates in 2009 dollars included $400 for a carrier screen and $260,000 for the lifetime cost of a child with severe disease. The researchers calculated maternal quality-adjusted-life-years assuming a 22 percent reduction in quality of life for having a child with severe SMA and 8 percent for fetal loss.

The researchers concluded that 11,000 women would have to be screened to prevent one case of SMA, at a cost of $4.7 million per case averted.

"Our findings show that screening everyone for SMA is not cost effective," study co-author Dr. Sarah Little, of Massachusetts General Hospital, said in a news release. "Our results, however, were most sensitive to changes in the baseline prevalence of disease, suggesting that prenatal SMA screening may be cost effective in high risk populations, such as those with a family history of disease."

The study was to be presented Friday at the annual meeting of the Society for Maternal-Fetal Medicine in Chicago.

More information

The Muscular Dystrophy Association has more about spinal muscular atrophy.



-- Robert Preidt



SOURCE: Society for Maternal-Fetal Medicine, news release, Feb. 5, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. FDA Approves New Roche West Nile Virus Blood Screening Test
2. New lung cancer guidelines oppose general CT screening
3. New Lung Cancer Guidelines Oppose General CT Screening
4. Lung Cancer Alliance Stands Behind CT Screening for Lung Cancer
5. Screening Proposed for Childhood Cholesterol Levels
6. A new technology for cancer screening listens for the signs of cancer
7. Study Questions Genetic Screening for Treatable Diseases
8. Cervical cancer screening: Too many are left unprotected
9. Simple, personalized interventions improve colorectal cancer screening rates
10. Doctors Office Outreach Boosts Colon Cancer Screening
11. Jefferson researchers find personalized interventions key to improving colon cancer screening rates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... ... May 02, 2016 , ... “Engineering Bubbles,” an oil painting submitted by Canadian ... Forum held recently at the Annual Meeting in Los Angeles. The first annual art ... members and Annual Meeting attendees. , “Through art I hope to educate people ...
(Date:5/2/2016)... ... May 02, 2016 , ... Dr. Philip Shindler, dentist in Agoura ... treatments. In the past, many necessary dental treatments could require multiple appointments to complete. ... shots and extra chair time. Not only could this be inconvenient, but it could ...
(Date:5/2/2016)... ... May 02, 2016 , ... This week Omega Institute, a premier nonprofit educational ... runs through October. Omega is offering a record 370 in-person workshops and new ... been such widespread interest in or need for the knowledge and skills we’ve been ...
(Date:5/2/2016)... ... May 02, 2016 , ... Visceral fat, also ... as the kidneys, liver and pancreas. If not properly addressed, visceral fat can ... in Internal Medicine, Medical Oncology and Palliative Care, warns against the dangers of ...
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... Pregnancy Awareness ... when trying to conceive. , “If you are ready to have a ... Seibel. “My book, HealthChequesTM: Journal Babies is your Personal Conception & Pregnancy Organizer, ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... Mich. , April 28, 2016   ... . Diplomat Pharmacy, Inc. (NYSE: DPLO), the nation,s ... has signed a definitive agreement to acquire Valley ... Specialty Pharmacy ("TNH"), a leading specialty pharmacy that ... Van Nuys, California . In 2015, TNH ...
(Date:4/28/2016)... Dr. ... und Stephen Schmidt werden Teil ... ein führender Anbieter cloudbasierter Softwarelösungen für den ... neue Führungskräfte zum Team Sicherheit und Pharmakovigilanz ... Erfahrungen mitbringen.  Dies wird die Geschäftseinheit Sicherheit ...
(Date:4/28/2016)... TOKYO , April 28, 2016 ... and Ste phen ... ArisGlobal®, a leading provider of cloud-based software solutions for ... and Pharmacovigilance team to bring a wealth of insight to a ... unparalleled pharmacovigilance knowledge. George Phillips joined ArisGlobal ...
Breaking Medicine Technology: