Navigation Links
Screening for Spinal Muscular Atrophy Not Cost-Effective: Study
Date:2/5/2010

But testing of high-risk couples could be viable, researchers say

FRIDAY, Feb. 5 (HealthDay News) -- It's not cost-effective to screen couples genetically to determine if they're at risk of having children with spinal muscular atrophy (SMA), says a U.S. study.

There is ongoing controversy about whether screening for SMA -- the most common genetic cause of infant death -- should be routinely offered to couples.

In this study, researchers created an analytical model to compare a policy of universal SMA screening to that of no screening. Baseline assumptions used in the model included a disease prevalence of 1 in 10,000 for a carrier rate of 1 in 50, 70 percent of affected children having severe disease.

The researchers also assumed a 90 percent sensitivity rate from carrier screening and that 2 percent of SMA cases arise from de novo mutations (genetic mutations not inherited from either parent).

The baseline cost estimates in 2009 dollars included $400 for a carrier screen and $260,000 for the lifetime cost of a child with severe disease. The researchers calculated maternal quality-adjusted-life-years assuming a 22 percent reduction in quality of life for having a child with severe SMA and 8 percent for fetal loss.

The researchers concluded that 11,000 women would have to be screened to prevent one case of SMA, at a cost of $4.7 million per case averted.

"Our findings show that screening everyone for SMA is not cost effective," study co-author Dr. Sarah Little, of Massachusetts General Hospital, said in a news release. "Our results, however, were most sensitive to changes in the baseline prevalence of disease, suggesting that prenatal SMA screening may be cost effective in high risk populations, such as those with a family history of disease."

The study was to be presented Friday at the annual meeting of the Society for Maternal-Fetal Medicine in Chicago.

More in
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. FDA Approves New Roche West Nile Virus Blood Screening Test
2. New lung cancer guidelines oppose general CT screening
3. New Lung Cancer Guidelines Oppose General CT Screening
4. Lung Cancer Alliance Stands Behind CT Screening for Lung Cancer
5. Screening Proposed for Childhood Cholesterol Levels
6. A new technology for cancer screening listens for the signs of cancer
7. Study Questions Genetic Screening for Treatable Diseases
8. Cervical cancer screening: Too many are left unprotected
9. Simple, personalized interventions improve colorectal cancer screening rates
10. Doctors Office Outreach Boosts Colon Cancer Screening
11. Jefferson researchers find personalized interventions key to improving colon cancer screening rates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... 2014 Principle Business Enterprises, a family ... manufacturing top-of-the-line absorbent products. The company has recently ... popular brand, Tranquility® Premium Protection absorbent products. The ... gave its packaging a new look, and is currently ... to the public. , The new website, developed with ...
(Date:10/20/2014)... 2014 Based on a proprietary ... imaging assays capable of determining DNA sequence, location ... these three dimensions of high-resolution data, dGH assays ... widest range of disease-causing genetic rearrangements, including chromosomal ... genomic tools, including today’s advanced sequencing technologies. , ...
(Date:10/20/2014)... Punzoné , the first line of ultra-premium organic ... to celebrate this month. October marks Italian Heritage Month – ... of Americans of Italian heritage and Italians in America. October ... its favorite Italian cocktails and encourages everyone to enjoy its ... it is only in a glass. , Punzoné continues ...
(Date:10/19/2014)... 2014 Recently, BambooIndustry.com, one of the ... new range of bamboo deckings . Moreover, the ... items; they are now available at deeply discounted rates. ... is hard to overstate the significance of online business ... online services. The company’s workers are striving to deliver ...
(Date:10/19/2014)... Recently, Fancyflyingfox.com, an innovative company that ... announced its latest designs of 2014 mother of ... elegant outfits are offered with big discounts, up to ... October 30 can enjoy this special offer. , ... it has become one of the leading brands in ...
Breaking Medicine News(10 mins):Health News:Tranquility® Premium Protection Incontinence Products Releases New Logo and Website 2Health News:KromaTiD Launches Genome Screening and Discovery Services 2Health News:KromaTiD Launches Genome Screening and Discovery Services 3Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 2Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 3Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 4Health News:High Quality Bamboo Deckings, New Items Unveiled By BambooIndustry.com 2Health News:Fancyflyingfox.com Updates Its Website With New Mother Of The Bride Dresses For 2014 2
... Care is undertaking an electronic medical record integration project ... is a multi-year, multi-entity corporate initiative to implement common ... in processes and workflows across the system. Currently in ... next four years, the way UMass Memorial collects, views, ...
... people to stay binge-free , THURSDAY, April 1 (HealthDay ... eating is effective and can save patients money, according ... asked to read the book "Overcoming Binge Eating," which ... six-step self-help program using self-monitoring, self-control and problem-solving strategies. ...
... ... with half of their tour profits donated to relief efforts for Haiti and Hurricane Katrina ... Philadelphia, PA (PRWEB) ... for the Half 4 Humanity Tour beginning April 5, 2010. The tour will ...
... Local swing set ... , ... When Tom Corcoran, owner of Kid Structures in Houston, was approached with an opportunity ... would do it but when he could get started. Just days away from the anticipated two-hour ...
... a cell wall and fuse with it could offer researchers ... of individual cells. Everything from signals generated as cells ... to medication could be monitored for up to a week, ... are so destructive they usually only allow a few hours ...
... in time for baseball,s opening day, a series of articles ... fairness in elite sports and what it takes to stop ... questions about which athletes are really "female," are explored. ... the lead essay Thomas H. Murray, president of The Hastings ...
Cached Medicine News:Health News:UMass Memorial health care develops fully integrated EMR 2Health News:Short-Term Program for Binge Eaters Breaks New Ground 2Health News:Eric from Philly and Alia Announce the Half 4 Humanity Tour 2Health News:Eric from Philly and Alia Announce the Half 4 Humanity Tour 3Health News:Eric from Philly and Alia Announce the Half 4 Humanity Tour 4Health News:Eric from Philly and Alia Announce the Half 4 Humanity Tour 5Health News:Kid Structures Prepares Houston's Beach Family for New Adventures 2Health News:Kid Structures Prepares Houston's Beach Family for New Adventures 3Health News:Kid Structures Prepares Houston's Beach Family for New Adventures 4Health News:Nanoscale 'stealth' probe slides into cell walls seamlessly, say Stanford engineers 2Health News:Nanoscale 'stealth' probe slides into cell walls seamlessly, say Stanford engineers 3Health News:Baseball season opener: Athletes and ethicists look at fairness in sport 2
(Date:10/19/2014)... October 19, 2014 Große ... Das Problem dabei ist, dass große Pharmafirmen ... Kompetenz zu teilen. Es war deshalb ... wir uns umso mehr, dass es uns gelungen ... bei Kühlketten aufzuschreiben - mit einem Vorbehalt - ...
(Date:10/17/2014)... HILL, N.C. , Oct. 17, 2014 /PRNewswire/ ... insights is a critical success factor in today,s ... must develop market research organizations that effectively and ... location, specialty or service area. ... create value and earn recognition from internal clients ...
(Date:10/17/2014)... Oct. 17, 2014 UBM Medica US announces that ... online community and information resource for neurologists and other healthcare ... Alzheimer disease , with discussions of the latest developments ... million Americans have Parkinson disease , more than the total ... Lou Gehrig disease. Diagnosis can be difficult because there ...
Breaking Medicine Technology:Vergleichsbericht zu Pharma-Kühlketten und CRT 2Effective Training Programs for Market Research Groups can Boost Overall Organizational Success 2Neurology Times Features Coverage of Parkinson and Alzheimer Disease 2Neurology Times Features Coverage of Parkinson and Alzheimer Disease 3
... March 19, 2012  BioStorage Technologies, a global provider ... cold chain logistics for the bioscience industry, announced ... webinar titled, "Comprehensive Sample Management: Leveraging an Onsite ... Thursday, March 22, from 11:00 AM to 12:30 ...
... Reportlinker.com announces that a new market research ... Branded Prescription Pharmaceutical Sales ... http://www.reportlinker.com/p0799256/Branded-Prescription-Pharmaceutical-Sales-Outlook-to-2016.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Pharmaceutical ... achieved sales of $558bn having experienced a ...
Cached Medicine Technology:BioStorage Technologies to Host Live Webinar on Optimizing the Value of Sample Assets 2Branded Prescription Pharmaceutical Sales Outlook to 2016 2Branded Prescription Pharmaceutical Sales Outlook to 2016 3Branded Prescription Pharmaceutical Sales Outlook to 2016 4Branded Prescription Pharmaceutical Sales Outlook to 2016 5
... The Finnpipette BioControl multichannel ... as the single channel model. ... all seven multichannel and five ... Both pipettes have a recharge ...
... solution and best value in high performance ... and ultra lightweight design reduce hand fatigue ... long, lever tip ejector , Color coding ... tips or for greater performance use Hamilton ...
... Pipette is ideal for all liquid handling ... ergonomically-placed operating buttons, and various dispensing techniques ... diluting make this a lab favorite. It ... manual pipette without any adverse effects on ...
... Unparalleled Comfort Pick one of our pipettors ... the trigger and ejector positionsright where they should ... are ergonomically designed to help avoid repetitive stress ... Productivity In The Palm Of Your Hand ...
Medicine Products: