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Screening for HPV persistence and cervical cancer risk
Date:9/6/2011

HPV testing more frequently than every two years for HPV-positive women.

The authors write, "Our findings suggest that, if upon testing an HPV infection is found, re-testing 2 years later would provide useful guidance as to the duration of infection and its risk." Furthermore, they say, "The accumulated evidence suggests that it is time to include HPV testing in cancer screening programs for the general population."

The researchers add that genotyping may improve HPV testing since certain carcinogenic HPV strainsnamely HPV16 and HPV58were associated with a higher risk of cervical cancer than others.

In an accompanying editorial, Kevin A. Ault, MD, of the Department of Gynecology and Obstetrics at Emory University School of Medicine notes that "persistent HPV infection is an intermediate step in the development of cervical cancer." He notes the study has several strengths, including long duration of follow-up, a large sample size, and linkage to the national cancer registry. He also adds that the study shows that women with negative HPV tests have a greatly reduced risk of developing cervical disease.


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Contact: Zack Rathner
jncimedia@oxfordjournals.org
301-841-1286
Journal of the National Cancer Institute
Source:Eurekalert

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