Navigation Links
Screen finds an antidepressant and other drugs

NEW YORK, September 14, 2011In a new study NYU School of Medicine researchers report that they have found several chemical compounds, including an antidepressant, that have powerful effects against brain-destroying prion infections in mice, opening the door to potential treatments for human prion diseases.

The researchers, led by Thomas Wisniewski, MD, professor of neurology, pathology and psychiatry, report their findings in today's online edition of PLoS One. Prion diseases are a family of rare progressive neurodegenerative disorders that affect both humans and animals. An unusual infectious agent, a priona misshapen version of a normal cellular proteincauses the fatal disorders. There are no treatments.

The researchers found that trimipramine, an antidepressant, and fluphenazine, an antipsychotic, have activity against prions. Since the drugs are already in clinical use, Dr. Wisniewski believes that doctors can test them in human patients with Creutzfeldt-Jakob disease, the most common human prion disease.

Dr. Wisniewski and his colleagues previously found 68 chemical compounds, known as styryl-based compounds, bound tightly to amyloid-beta protein deposits in the brains of people who died of Alzheimer's disease. Since the disease-causing aggregates of amyloid-beta and prion proteins are widely believed to have similar structures, his team screened these 68 styryl-based compounds for their ability to inhibit prion infection in a standard cell culture. They found two that seemed both effective and non-toxic, and confirmed their effectiveness by showing that on average they markedly delayed the onset of symptoms in prion-injected lab mice. The styryl-based compounds also reduced the signs of disease in the mouse brains.

Dr. Wisniewski's team found similar results the antidepressant trimipramine and the anti-schizophrenia drug fluphenazine. Both are chemically related to the anti-protozoal drug quinacrine, which is known to slow prion infection in cell cultures, although it fails to protect prion-infected mice or humans. Their chemical differences from quinacrine apparently enable the two drugs to bind more tightly to toxic prion aggregates, andlike the styryl-based compoundsprevent these aggregates from assembling new copies of themselves.

"One of the trimipramine-treated mice stayed healthy throughout the 400-day study," Dr. Wisniewski says.

The National Institutes of Health funds Dr. Wisniewski's laboratory's work to develop potential prion-disease vaccines. Prion diseases in animals have been known to jump to the human population. A prion disease known as bovine spongiform encephalopathy (BSE, also known as "mad cow disease") swept through cattle in Britain in the 1980s, infected humans via beef products, and killed more than 200 people worldwide.

Currently a prion disease known as chronic wasting disease (CWD) is spreading through the deer and elk population of North America. Humans are increasingly exposed to CWD, for example by eating venison, and although CWD so far doesn't seem transmissible to humans, it has been shown to infect other primates. Dr. Wisniewski and colleagues are testing an oral vaccine for CWD in deer and elk in Colorado.


Contact: Christopher Rucas
NYU Langone Medical Center / New York University School of Medicine

Related medicine news :

1. Screening Lots of Lymph Nodes Little Help for Colon Cancer Patients
2. Screening for HPV persistence and cervical cancer risk
3. Troubled Teens Spotted in Routine School Screenings: Study
4. Steps Outlined to Screen All Newborns for Heart Defects
5. Newest screen for newborns will indicate heart problems
6. Single flexible sigmoidoscopy screening associated with reduced colorectal cancer
7. Annual cervical cancer screening persists, despite recommended guidelines
8. New prostate cancer screening test shows promise for diagnosis
9. Noninvasive fecal occult blood test effective screen for lower GI tract lesions
10. New high-speed 3-D imaging system holds potential for improved cancer screening
11. Drop in Breast Cancer Death Rates May Not Be Linked to Screening Rates
Post Your Comments:
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Those who have ... these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as ... Michigan, has released tools for healthy coping following a traumatic event. , Trauma sufferers ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are ... for this recognition are considered among the top 2 percent of lawyers practicing within ... of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, ...
(Date:6/24/2016)... TX (PRWEB) , ... June 24, 2016 , ... People ... part in Genome magazine’s Code Talker Award, an essay contest in which patients and ... an award to be presented at the 2016 National Society of Genetic Counselors (NSGC) ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... actively feeding the Frederick area economy by obtaining investment capital for emerging technology ... past 2½ years that have already resulted in more than a million dollars ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the addition of the ... to 2022" report to their offering. ... financial data derived from varied research sources to present unique ... on the market during the next five years, including a ... markets, regional and country level analysis. The report provides a ...
(Date:6/23/2016)... , , , WHEN: , , ... , , , LOCATION: , , , Online, with free registration ... PANELISTS:  , , , Frost & Sullivan,s Global Vice President of ... Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... witnessing an exceptional era. Several new demand spaces, such as innovative ...
(Date:6/23/2016)... N.J. , June 23, 2016  Guerbet announced ... Premier Inc.,s Supplier Horizon Award . ... year, Guerbet was recognized for its support of Premier ... creation through clinical excellence, and commitment to lower costs. ... to receive this recognition of our outstanding customer service ...
Breaking Medicine Technology: