Navigation Links
Scott & White Healthcare pathologist is co-investigator on breast cancer study

In a laboratory study published in the journal Cancer Research, Scott & White Healthcare anatomic pathologist Arundhati Rao, M.D. is a co-investigator looking at the ways in which estrogen can interfere with how chemotherapy does its job in destroying breast cancer cells. The most common type of breast cancer is "estrogen-receptor positive" breast cancer.

Velusamy Rangasamy and Ajay Rana, Ph.D., are also the lead authors on the study and are based at Loyola University Medical Center in Chicago where Dr. Rana is a professor of pharmacology.

"What we know is that not all breast tumors are the same and if a tumor is estrogen-receptor positive, it's possible that chemotherapy isn't going to be as effective as it could be," said Dr. Rao. "This is why we see some breast cancer patients on chemo that isn't working like it should. With this additional information regarding estrogen, it could help us create more targeted therapies in the future."

"These findings are important because efficiently killing estrogen receptor positive (ER+) breast cancer cells with currently available chemotherapy is a challenging task and many times these ER+ breast tumors don't respond to classical chemotherapy," said Dr. Rana. "Our research identified an alternative cellular protein which can serve as a viable target for ER+ breast cancer treatment."

Dr. Rao went on to say that "with this research we found that in order to make cancer drugs work better, we may need to give patients a different drug and this could possibly shorten the duration of their chemotherapy course if we knew more."

"Our work suggests that any drugs/agents that will activate this protein will sensitize the ER+ breast cancer cells toward commonly used chemotherapies. We have been working to find the drugs/agents that can activate this protein and kill the ER+ cancer cells," said Dr. Rana.

Dr. Rana explained that "these findings are encouraging but further research is needed to find how this cellular pathway could be utilized to target estrogen positive breast cancer cells."


Contact: Katherine Voss
Scott & White Healthcare

Related medicine news :

1. Scott & White Memorial Hospital uses device to revolutionize treatment of traumatic aortic injury
2. Trustmark and HealthFitness Announce Early Termination of Hart-Scott-Rodino Waiting Period
3. Scott Roeder Trial: Randall Terry, Operation Rescue Founder and Insurrecta Nex Members to Attend Trial in Wichita
4. New study shows TGen spin-off boosts Scottsdale economy
5. Let Us Mute Our Praise for Scott Brown - a "Moderate" Child-Killer - and Seek to Replace Him With a True Pro-Lifer in Two Years, Says Randall Terry
6. Scott & White Healthcare researching treatments for rare cancers
7. Julian Lennon and James Scott Cook Release New Charity Single LUCY to Raise Awareness and Funds for Lupus Research
8. Dr. Daniel Von Hoff named honoree of Scottsdale Healthcare Foundation Honor Ball
9. Valley Health Invention Making National Splash Showcased at Scottsdale Civic Center Gallery
10. Affordable Acupuncture Greeted with Open Arms by Scottsdale and Phoenix Communities
11. Dip into a Healthy Holiday with the Taste of Texas Oncology's Holly Jolly Biscotti
Post Your Comments:
(Date:11/24/2015)... ... November 24, 2015 , ... Eric C. Seidel, DMD and ... of the revolutionary BIOLASE WaterLase iPlus 2.0™ system. This advanced laser technology uses ... a dentist in Gettysburg, PA . From routine visits to cosmetic treatments, ...
(Date:11/24/2015)... ... November 24, 2015 , ... New patients who wish to seek ... dental implants at her Mississauga, ON practice. Dr. Williams has been providing ... of dental implants. , Missing teeth can lead to a variety of complications ...
(Date:11/24/2015)... Dallas, Texas (PRWEB) , ... November 24, 2015 , ... ... of all charitable donations are made in the last five weeks of the year ... #GivingTuesday was created in 2012 to connect the nation’s charities with those individuals who ...
(Date:11/24/2015)... , ... November 24, 2015 , ... In an ... restrictions and variables that determine which patients are or are not eligible for bariatric ... have a BMI over 40, are more than 100 pounds overweight, or have a ...
(Date:11/24/2015)... ... November 24, 2015 , ... DMG Productions announced that they will feature ... quarter 2016 via Discovery Channel. Dates and show times TBA. , Aphria, Inc., is ... the business of producing and supplying medical marijuana pursuant to the Marijuana for Medical ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... 2015 ... the  "Global Drug Device Combination Products ... offering.  --> ) ... "Global Drug Device Combination Products Market ... --> Research and Markets ( ...
(Date:11/24/2015)... CARLOS, Calif. , Nov. 24, 2015 ... a leader in non-invasive genetic testing and ... announced that it will present at the ... in New York on Wednesday, December 2, 2015 at 1:00 p.m. ET.  Matthew ... the Company,s financial results, business activities and ...
(Date:11/24/2015)... Nueva York , 24 de noviembre de ... del Avery Breathing Pacemaker System, se complace anunciar ... Ph.D. como consultor clínico. ... Foto -   ... Jonzon es un fisiólogo y consultor en neonatología ...
Breaking Medicine Technology: