Navigation Links
Scopolamine: An old drug with new psychiatric applications
Date:2/12/2013

Philadelphia, PA, February 12, 2013 Scopolamine is an anticholinergic drug with many uses. For example, it prevents nausea, vomiting, and motion sickness.

However, scopolamine is re-emerging as an antidepressant, with recent studies showing that scopolamine can rapidly improve mood in depressed patients. In addition, in a new study published in Biological Psychiatry this month by Dr. Moriel Zelikowsky and colleagues at the University of California, Los Angeles, it may also be a possible treatment for anxiety disorders.

Exposure therapy, where the key goal is the elimination of fear through repeated 'safe' exposure to the threat, is commonly employed for the treatment of anxiety disorders. However, its effectiveness is diminished because humans and animals alike tend to be very sensitive to context, causing extinction learning to be dependent on the environment in which it occurs. This makes memories formed during extinction unstable. As a result, extinguished fears commonly return when people put themselves in new situations.

"Current research aimed at treating this problem either employs invasive, untranslatable methods or attempts to strengthen extinction learning rather than prevent relapse," explained senior author Dr. Michael Fanselow.

In an effort to solve this dilemma, Fanselow and his team took a novel theoretical approach. Employing an animal model of exposure therapy, they found they were able to disrupt the rats' contextual processing during extinction using low doses of scopolamine, which blocked the return of fear when the rats were exposed to both the original and a new context.

"This finding provides groundbreaking evidence that changing the nature of extinction learning, rather than its magnitude, can produce profound improvements in the prevention of relapse," added Fanselow.

Scopolamine also slowed the rate of extinction memory formation, which was overcome by adding training sessions. Taken together, these findings indicate that scopolamine may serve as a promising pharmacological adjunct to exposure therapy by improving one's resiliency to environmental changes.

"The emerging new uses for scopolamine are quite promising, although further research is needed," commented Dr. John Krystal, Editor of Biological Psychiatry. "These new data are a wonderful example of the capacity of translational neuroscience approaches to identify new uses for old medications."


'/>"/>
Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Related medicine news :

1. Symptomatic behaviour in childhood strongly predicts psychiatric treatment as a young adult
2. Psychiatric Patients Often Wait Nearly 12 Hours in ER
3. Bias found in mental health drug research presented at major psychiatric meeting
4. Childless women with fertility problems at higher risk of hospitalization for psychiatric disorders
5. Children with autism arrive at emergency room for psychiatric crisis 9 times more than peers
6. For Psychiatric Patients, Cancer Is Often Spotted Too Late
7. Protecting psychiatric medical records puts patients at risk of hospitalization
8. Study examines link between incarceration and psychiatric disorders
9. Frontiers publishes systematic review on the effects of yoga on major psychiatric disorders
10. Family practice offers genetic tests to predict effective psychiatric meds, a CAMH study
11. Application Development Firm Anahata Technologies Pty Ltd Announces JavaFX 2.0 as Technology of Choice for Enterprise Applications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to ... a new, often overlooked aspect of head lice: the parasite’s ability to live away from ... common occurrence, but a necessary one in the event that lice have simply gotten out ...
(Date:6/25/2016)... Lewisville, TX (PRWEB) , ... June 25, 2016 , ... ... in the United States, named Dr. Sesan Ogunleye, as the Medical Director of its ... be the facility Medical Director of our new Mesquite location,” said Dr. James M. ...
(Date:6/25/2016)... Oklahoma (PRWEB) , ... June 25, 2016 , ... ... both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures ... Oklahoma City area —Johnson is one of the first doctors to perform the ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the ... In terms of the latter, setting the bar too high can result in disappointment, ... just slow progress toward their goal. , Research from PsychTests.com reveals ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic ... many turn to unhealthy avenues, such as drug or alcohol abuse, as a coping ... released tools for healthy coping following a traumatic event. , Trauma sufferers tend to ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 Roche ... received 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) ... severe sepsis or septic shock. With this clearance, Roche ... provide a fully integrated solution for sepsis risk assessment ... associated with bacterial infection and PCT levels in blood ...
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on ... today announced that patient enrollment in its ongoing ... Duchenne) has exceeded 50% of its 24-patient target. ... in the third quarter of 2016, and to ...
(Date:6/23/2016)... , June 23, 2016 Bracket , a ... its next generation clinical outcomes platform, Bracket eCOA (SM) ... on June 26 – 30, 2016 in Philadelphia ... electronic Clinical Outcome Assessment product of its kind to fully ... Bracket eCOA 6.0 is a flexible platform for ...
Breaking Medicine Technology: