Navigation Links
Scientists unwrap DNA packaging to gain insight into cells
Date:9/2/2010

Scientists have built a clearer picture of how lengthy strands of DNA are concertinaed when our cells grow and divide, in a discovery could help explain how cell renewal can go wrong.

Scientists have identified thousands of proteins that play a key role in compacting DNA a crucial process by which DNA is shortened up to 10,000 times to fit inside cells as they split into two.

Researchers hope the findings could shed light on what happens when this packaging process fails and cells divide abnormally which can lead to cancer or cause developing embryos to miscarry.

Scientists developed a new technology for their research by combining existing techniques in biology, genetics and maths and the large-scale study of proteins. They were able to define some 4,000 proteins involved in the division of cells. The proteins protect the fragile genetic material and help it fold into the correct shape before it splits into two new cells. The new methods can identify many of those proteins that are most important to the process.

University of Edinburgh scientists, who carried out the study, hope the discovery will help them better understand how these proteins influence the process of cell division.

The research was carried out in collaboration with the University of Oxford and the Japanese National Institute of Genetics in Mishima, Japan. It was supported by the Wellcome Trust and published in the journal Cell.

Professor William Earnshaw of the University of Edinburgh's School of Biological Sciences, who directed the study with Professor Juri Rappsilber, said: "Until now, our understanding of the very complex way in which DNA moves during cell division was patchy this latest development allows us, for the first time, to fully identify all the proteins that take part in the process, and how they interact with one another. Future work is needed to reveal more of the intricacies of this process and how to prevent it from going wrong."


'/>"/>

Contact: Catriona Kelly
catriona.kelly@ed.ac.uk
44-131-651-4401
University of Edinburgh
Source:Eurekalert

Related medicine news :

1. Scientists discover key to Christmas Islands red crab migration
2. Scientists find link in humans between nerve cell production, memory
3. Scientists Dismayed by Stem Cell Research Ruling
4. Scientists closer to finding what causes the birth of a fat cell
5. Scientists map epigenetic changes during blood cell differentiation
6. Scientists receive nearly $11 million to develop radiation countermeasures
7. Chemical system in brain behaves differently in cocaine addicts, UT Southwestern scientists find
8. Scientists Unravel Secrets of Sound Sleep
9. Scientists develop the first model for investigating the origins of testicular cancer in humans
10. Scientists develop designer protein, opening new door in cancer research
11. Scientists unravel human-ecosystem interactions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ... viewers the lowdown on sciatica in a new episode of "Success Files," which ... current events and innovation and investigates each subject in-depth with passion and integrity. ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian ... On The Brink” is the creation of published author, William Nowers. Captain Nowers ... a WWII veteran, he spent thirty years in the Navy. Following his career ...
(Date:10/12/2017)... Orleans, LA (PRWEB) , ... October 12, 2017 , ... ... centers in the U.S., announced today its plans to open a flagship location in ... will occupy the former Rooms To Go store next to Office Depot in the ...
(Date:10/12/2017)... ... 2017 , ... The American College of Medical Informatics (ACMI) will present the ... Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium ... a pioneer in the field of medical informatics, this prestigious award is presented to ...
(Date:10/12/2017)... LOS ANGELES (PRWEB) , ... October 12, 2017 ... ... of Parsa Mohebi Hair Restoration, has recently contributed a medical article to the ... doctors, on cosmetictown.com. Dr. Mohebi’s article spotlights the hair transplant procedure known as ...
Breaking Medicine News(10 mins):
(Date:10/5/2017)... 2017  In response to the nationwide opioid ... Surgeons (AAOMS) released prescribing recommendations that urge ibuprofen ... as a first-line therapy to manage a patient,s ... Recognizing the value and importance of ... Prescribing: Acute and Postoperative Pain Management" stresses that ...
(Date:10/2/2017)... Oct. 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... Software and Consulting, LLC , and named its founder ... based in Tennessee , will operate ... expands EnvoyHealth,s service offerings for health care partners to ... "In an interoperable world, technology ...
(Date:10/2/2017)... -- The Rebound mobile app is poised to become a ... of prescription drug addiction. The app empowers users to develop ... down their dosage in a safe, controlled manner while maximizing ... first 100,000 people to sign up will enjoy 3 months ... ...
Breaking Medicine Technology: