Navigation Links
Scientists unwrap DNA packaging to gain insight into cells
Date:9/2/2010

Scientists have built a clearer picture of how lengthy strands of DNA are concertinaed when our cells grow and divide, in a discovery could help explain how cell renewal can go wrong.

Scientists have identified thousands of proteins that play a key role in compacting DNA a crucial process by which DNA is shortened up to 10,000 times to fit inside cells as they split into two.

Researchers hope the findings could shed light on what happens when this packaging process fails and cells divide abnormally which can lead to cancer or cause developing embryos to miscarry.

Scientists developed a new technology for their research by combining existing techniques in biology, genetics and maths and the large-scale study of proteins. They were able to define some 4,000 proteins involved in the division of cells. The proteins protect the fragile genetic material and help it fold into the correct shape before it splits into two new cells. The new methods can identify many of those proteins that are most important to the process.

University of Edinburgh scientists, who carried out the study, hope the discovery will help them better understand how these proteins influence the process of cell division.

The research was carried out in collaboration with the University of Oxford and the Japanese National Institute of Genetics in Mishima, Japan. It was supported by the Wellcome Trust and published in the journal Cell.

Professor William Earnshaw of the University of Edinburgh's School of Biological Sciences, who directed the study with Professor Juri Rappsilber, said: "Until now, our understanding of the very complex way in which DNA moves during cell division was patchy this latest development allows us, for the first time, to fully identify all the proteins that take part in the process, and how they interact with one another. Future work is needed to reveal more of the intricacies of this process and how to prevent it from going wrong."


'/>"/>

Contact: Catriona Kelly
catriona.kelly@ed.ac.uk
44-131-651-4401
University of Edinburgh
Source:Eurekalert

Related medicine news :

1. Scientists discover key to Christmas Islands red crab migration
2. Scientists find link in humans between nerve cell production, memory
3. Scientists Dismayed by Stem Cell Research Ruling
4. Scientists closer to finding what causes the birth of a fat cell
5. Scientists map epigenetic changes during blood cell differentiation
6. Scientists receive nearly $11 million to develop radiation countermeasures
7. Chemical system in brain behaves differently in cocaine addicts, UT Southwestern scientists find
8. Scientists Unravel Secrets of Sound Sleep
9. Scientists develop the first model for investigating the origins of testicular cancer in humans
10. Scientists develop designer protein, opening new door in cancer research
11. Scientists unravel human-ecosystem interactions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... May 04, 2016 , ... The Lymphoma ... innovative lymphoma research and serving the lymphoma community through a comprehensive series of ... the esteemed Quaker Ridge Golf Club in Scarsdale, New York on May 23, ...
(Date:5/4/2016)... ... May 04, 2016 , ... The Spiritual Care ... recognize chaplains for their valuable support to patients and their families, and their overall ... , To mark Spiritual Care Day, SCA has sent “Thank You Chaplain” cards with ...
(Date:5/4/2016)... ... , ... Hight-Doland Insurance Agency’s new community involvement program which serves families of ... of Southwest Louisiana to help provide positive mentoring for local youth. Donations to this ... of Southwest Louisiana has been helping to guide the area’s youth for over 30 ...
(Date:5/4/2016)... Island (PRWEB) , ... May 04, 2016 , ... ... in April 2016. SS&A teamed up with one of the top website design ... information portal contains informative legal articles related to the law firm's main practice ...
(Date:5/4/2016)... ... May 04, 2016 , ... Recognizing that lifestyle medicine is essential ... Verywell, have tapped David Katz, MD, MPH, president of the American College of ... to lifestyle medicine is especially gratifying,” said Katz. “There is so much opportunity to ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... DUBLIN , May 4, 2016 /PRNewswire/ ... the addition of the  "Global Multiple Myeloma ...  report to their offering.       ... Multiple Myeloma Market and Competitive Landscape Highlights ... pipeline products, Multiple Myeloma epidemiology, Multiple Myeloma ...
(Date:5/4/2016)... Research and Markets has ... Keratosis Market and Competitive Landscape Highlights - ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ... Highlights 2016, provides comprehensive insights into Actinic ... Keratosis market valuations and forecast, Actinic Keratosis ...
(Date:5/3/2016)... May 3, 2016 BioNovus Innovations LLC ... for Advancing Medical Innovation (IAMI) today announced a ... diagnostics and medical devices. An agreement ... rights to license, develop and commercialize medical innovations ... "This partnership represents a significant advance in ...
Breaking Medicine Technology: