Navigation Links
Scientists unveil secrets of important natural antibiotic
Date:2/21/2013

An international team of scientists has discovered how an important natural antibiotic called dermcidin, produced by our skin when we sweat, is a highly efficient tool to fight tuberculosis germs and other dangerous bugs.

Their results could contribute to the development of new antibiotics that control multi-resistant bacteria.

Scientists have uncovered the atomic structure of the compound, enabling them to pinpoint for the first time what makes dermcidin such an efficient weapon in the battle against dangerous bugs.

Although about 1700 types of these natural antibiotics are known to exist, scientists did not until now have a detailed understanding of how they work.

The study, carried out by researchers from the University of Edinburgh and from Goettingen, Tuebingen and Strasbourg, is published in Proceedings of the National Academy of Sciences.

Sweat spreads highly efficient antibiotics on to our skin, which protect us from dangerous bugs. If our skin becomes injured by a small cut, a scratch, or the sting of a mosquito, antibiotic agents secreted in sweat glands, such as dermcidin, rapidly and efficiently kill invaders.

These natural substances, known as antimicrobial peptides (AMPs), are more effective in the long term than traditional antibiotics, because germs are not capable of quickly developing resistance against them.

The antimicrobials can attack the bugs' Achilles' heel their cell wall, which cannot be modified quickly to resist attack. Because of this, AMPs have great potential to form a new generation of antibiotics.

Scientists have known for some time that dermcidin is activated in salty, slightly acidic sweat. The molecule then forms tiny channels perforating the cell membrane of bugs, which are stabilised by charged particles of zinc present in sweat. As a consequence, water and charged particles flow uncontrollably across the membrane, eventually killing the h
'/>"/>

Contact: Catriona Kelly
Catriona.Kelly@ed.ac.uk
44-131-651-4401
University of Edinburgh
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Fungi offers new clues in asthma fight, say Cardiff scientists
2. Scientists find promising new approach to preventing progression of breast cancer
3. Hopkins scientists create method to personalize chemotherapy drug selection
4. Spanish scientists develop a pioneering technique to effectively treat mucositis
5. Scientists find calcium is the initial trigger in our immune response to healing
6. Scientists should advance management of behavioral norms
7. Scientists advance the art of magic with a study of Penn and Tellers cups and balls illusion
8. CSHL scientists identify a new strategy for interfering with a potent cancer-causing gene
9. Scientists Find 24 New Genes Linked to Nearsightedness
10. NIH scientists discover promising target to block Staphylococcus infection
11. Scientists find key to growth of bad bacteria in inflammatory bowel disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/4/2015)... ... September 04, 2015 , ... Having access to a doctor can sometimes ... increasing amount of unnecessary emergency room visits which affects hospitals’ abilities to provide quality ... bill. Fortunately, a solution to alleviate this problem has recently presented itself, the new ...
(Date:9/4/2015)... NY (PRWEB) , ... September 04, 2015 , ... Lalonde ... qualifying heat, and followed up with victory in the men’s 400 meters final, with ... Senior Track and Field Championships in San Jose, Costa Rica in August 2015. The ...
(Date:9/4/2015)... ... September 04, 2015 , ... Compliance officers ... settlements under the Stark physician self-referral law. “Stark Law DOs and DON’Ts: ... Atlantic Information Services, Inc. (AIS), will detail which deals are attracting the most ...
(Date:9/4/2015)... ... 04, 2015 , ... FiltersFast.com, the online retail leader in ... passed up. FiltersFast.com, will ship all orders over $50.00 for free. Use ... Take advantage of this promotion now through September 8, 2015. , Filtersfast.com offers ...
(Date:9/4/2015)... ... September 04, 2015 , ... Friday night, Chicago lovebirds Jenny McCarthy ... A Night of Hope event supporting families affected by autism, raising nearly $250,000. ... Salas, joined together at the Oscar Swan Inn to support the cause. , ...
Breaking Medicine News(10 mins):Health News:Telemedicine Platform DocChat Announces Launch Offering a Way for Patients to Consult Doctors and Receive Prescriptions 24/7 2Health News:Telemedicine Platform DocChat Announces Launch Offering a Way for Patients to Consult Doctors and Receive Prescriptions 24/7 3Health News:Lalonde Gordon’s Recipe Brings Home the Gold 2Health News:Lalonde Gordon’s Recipe Brings Home the Gold 3Health News:Sept. 17 Webinar to Offer Best Practices for Physician Contracts 2Health News:FiltersFast.com Wows with a Long Labor Day Weekend Shipping Offer 2Health News:Jenny McCarthy & Donnie Wahlberg Help Raise Over $200,000 For Generation Rescue’s ‘Night Of Hope’ Chicago Charity Event 2
... giants, yoga guru Baba Ramdev said here Wednesday that soft ... to drink only fruit juice and milk to keep diseases ... at the Science College ground here at a camp, Ramdev ... practice yoga everyday early morning rather than consuming cold drinks., ...
... times when most people just don’t move away from ... helps them to fulfill psychological needs. ,University of ... and enquired from 1000 gamers their motivation to keep ... Emotion this month suggest that people enjoy video games ...
... sensor that identifies glucose levels. This sensor plays an important ... that increases or decreases the manufacture of glucose inside the ... into fat for the purpose of storage in adipose tissue. ... makes it a potential site that can be targeted to ...
... In a case study in PLoS Medicine, doctors report ... user who came to the accident and emergency department ... muscle weakness. The diagnosis turned out to be wound ... that occurs when spores of the bacterium Clostridium botulinum ...
... weaken the bones in the long run and increase the ... doctors to consider the risk when// prescribing such drugs. ... studied records from the general practice research database of Britain. ... had been taking proton pump inhibitors (PPI). ...
... of the major human ancestry groups, with relatively little genetic ... according to a// new US study. ,Although the ... from India, these results still suggest that the frequencies of ... parts of the world, an Indian American scientist who led ...
Cached Medicine News:Health News:Why People are Addicted to Video Games? 2Health News:Glucose Sensor That Controls Glucose Metabolism Identified 2Health News:Indians Make One Major Human Race: US Study 2
(Date:9/3/2015)... , Sept. 3,  2015 About ... bio-artificial devices, which are implanted or integrated ... organs. These include artificial heart, kidney, pancreas, ... polymers (polyurethane, polysulfone, and porous polypropylene), biologics, ... artificial organs. These organs are incorporated with ...
(Date:9/3/2015)... 3, 2015 About dry eye syndrome Dry ... to deficient tear production or quick tear evaporation or ... types: aqueous tear deficient dry eye and evaporative dry ... do not produce enough tears, whereas meibomian gland dysfunction ... to slow tear evaporation and maintain tear stability. The ...
(Date:9/3/2015)... Sept. 3, 2015  Ascendis Pharma A/S ... biotechnology company that applies its innovative TransCon ... today announced plans to present at several ... Healthcare Conference in BostonDate: , Thursday, September ... of America Merrill Lynch Global Healthcare Conference ...
Breaking Medicine Technology:Global Artificial Organ Market 2015-2019 2Global Dry Eye Syndrome Market 2015-2019 2Ascendis Pharma A/S to Present at Three Upcoming Investor Conferences 2
... WIRE)--May 21, 2007 - Cougar Biotechnology,Inc. (OTCBB:CGRB) today ... on the Company's prostate cancer drug candidate CB7630,(abiraterone ... Annual Meeting, which is currently taking place,in Anaheim, ... A.,Yap from the Cancer Research UK Centre for ...
... 40/12.5 and 40/25 mg/day and Amlodipine +,Benazepril ... Society of,Hypertension Twenty-Second Annual Scientific Meeting, PARSIPPANY, ... data,presented today at the American Society of ... Chicago,demonstrated that the fixed-dose combination Benicar HCT,(olmesartan ...
Cached Medicine Technology:Cougar Biotechnology Announces Presentation of Positive CB7630,Clinical Data at AUA Annual Meeting 2Cougar Biotechnology Announces Presentation of Positive CB7630,Clinical Data at AUA Annual Meeting 3Cougar Biotechnology Announces Presentation of Positive CB7630,Clinical Data at AUA Annual Meeting 4Benicar HCT Reductions in Seated Systolic Blood Pressure for Stage,2 Patients Compared With Amlodipine + Benazepril 2Benicar HCT Reductions in Seated Systolic Blood Pressure for Stage,2 Patients Compared With Amlodipine + Benazepril 3Benicar HCT Reductions in Seated Systolic Blood Pressure for Stage,2 Patients Compared With Amlodipine + Benazepril 4Benicar HCT Reductions in Seated Systolic Blood Pressure for Stage,2 Patients Compared With Amlodipine + Benazepril 5Benicar HCT Reductions in Seated Systolic Blood Pressure for Stage,2 Patients Compared With Amlodipine + Benazepril 6Benicar HCT Reductions in Seated Systolic Blood Pressure for Stage,2 Patients Compared With Amlodipine + Benazepril 7Benicar HCT Reductions in Seated Systolic Blood Pressure for Stage,2 Patients Compared With Amlodipine + Benazepril 8
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: