Navigation Links
Scientists unlock secrets of protein produced by disease-causing fungus
Date:4/16/2014

SAN ANTONIO, Texas (April 16, 2014) A team that includes scientists from the School of Medicine at The University of Texas Health Science Center at San Antonio, Johns Hopkins University and St. Mary's University reported the structure of a protein that helps a common fungus to infect the body.

The fungal pathogen Candida albicans causes yeast infections, diaper rashes and oral thrush, and is the most common fungal pathogen to infect humans. It can also cause a life-threatening infection of the blood called disseminated candidiasis.

"In this study, we determined the three-dimensional structure of a never-before-seen cell wall protein called SOD5 that the organism uses as a defense against the human immune system," said P. John Hart, Ph.D., the Ewing Halsell-President's Council Distinguished Professor of biochemistry at the UT Health Science Center and Research Scientist in the South Texas Veterans Health Care System.

"SOD5 is a copper-only protein that exhibits significant structural differences from copper/zinc superoxide dismutases (SODs)," Dr. Hart said. "Because SOD5 molecules are widespread throughout fungi, including C. albicans, but are not found in humans, the structural differences can be exploited to develop compounds that specifically target SOD5 to treat a number of widespread fungal infections."

Current conventional antifungal treatments such as fluconazole can be toxic to the liver in certain individuals, he noted.

"SOD5 is an unprecedented, very powerful antioxidant protein that enables C. albicans to ward off free radicals of the host immune response," said study senior author Valeria Culotta, Ph.D., professor of biochemistry and molecular biology and environmental health sciences at the Johns Hopkins University Bloomberg School of Public Health. Free radicals are highly reactive molecules that can cause oxidative damage.


'/>"/>

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert

Page: 1

Related medicine news :

1. Kessler Foundation scientists receive Biogen Idec grant to study actual reality in MS
2. Scientists discover a number of novel genetic defects which cause oesophageal cancer
3. Scientists find potential target for treating mitochondrial disorders
4. Scientists describe gut bacteria that cause sepsis in preterm infants
5. Virginia Tech scientists out for blood when it comes to stopping malaria
6. U-M scientists slow development of Alzheimers trademark cell-killing plaques
7. NIH scientists track evolution of a superbug
8. In the lab, scientists coax E. coli to resist radiation damage
9. Let there be tissue-penetrating light: Scientists develop new nanoscale method to fight cancer
10. Scientists discover new protein involved in lung cancer
11. Scientists explore promising new option for first line of attack in lymphoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... ... 2016 , ... Spring Fertility , the only fertility ... egg freezing, today announced the grand opening of its first location in San ... Fertility offers both fertility preservation (egg, sperm, embryo, and testicular and ovarian tissue ...
(Date:5/5/2016)... Francisco, CA (PRWEB) , ... ... ... intensive lectures and hands-on exercises, the Wharton Seminars for Business Journalists ... a better understanding of key business and economic issues.  This one-day program ...
(Date:5/5/2016)... ... May 05, 2016 , ... ... announces McLaughlin & Smoak Benefits as the latest addition to its family of ... a dedicated team of compliance, wellness, human resources, and health care consumerism specialists. ...
(Date:5/5/2016)... ... May 05, 2016 , ... Every year 220 Mississippi kids ... of these children. The wishes provide hope and motivation through positive experiences ... Make-A-Wish Mississippi, Brent Wilson said, “In 2016, the organization will grant 50% of ...
(Date:5/5/2016)... (PRWEB) , ... May 05, 2016 , ... ... commencement of a master charity program created to assist the people of their ... working closely with nonprofit organizations and community leaders. Their hope is to bring ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... 2016 Yissum Research Development ... today that it had signed an exclusive world-wide licensing ... of novel protein degradation and immunomodulatory drugs for cancer ... drug candidates representing first-in-class therapy for hematologic and solid ... The novel technology was developed by ...
(Date:5/4/2016)... , May 4, 2016 ... addition of the  "Global Acute Myeloid Leukemia ...  report to their offering.       ... Acute Myeloid Leukemia Market and Competitive Landscape ... Myeloid Leukemia pipeline products, Acute Myeloid Leukemia ...
(Date:5/3/2016)... -- Research and Markets has announced the ... Market Outlook 2020" report to their offering. ... technology has improved significantly in past years due to ... coming years. Many cancer drugs have been developed by ... also expected to be developed with its help. They ...
Breaking Medicine Technology: