Navigation Links
Scientists unlock secrets of protein produced by disease-causing fungus

SAN ANTONIO, Texas (April 16, 2014) A team that includes scientists from the School of Medicine at The University of Texas Health Science Center at San Antonio, Johns Hopkins University and St. Mary's University reported the structure of a protein that helps a common fungus to infect the body.

The fungal pathogen Candida albicans causes yeast infections, diaper rashes and oral thrush, and is the most common fungal pathogen to infect humans. It can also cause a life-threatening infection of the blood called disseminated candidiasis.

"In this study, we determined the three-dimensional structure of a never-before-seen cell wall protein called SOD5 that the organism uses as a defense against the human immune system," said P. John Hart, Ph.D., the Ewing Halsell-President's Council Distinguished Professor of biochemistry at the UT Health Science Center and Research Scientist in the South Texas Veterans Health Care System.

"SOD5 is a copper-only protein that exhibits significant structural differences from copper/zinc superoxide dismutases (SODs)," Dr. Hart said. "Because SOD5 molecules are widespread throughout fungi, including C. albicans, but are not found in humans, the structural differences can be exploited to develop compounds that specifically target SOD5 to treat a number of widespread fungal infections."

Current conventional antifungal treatments such as fluconazole can be toxic to the liver in certain individuals, he noted.

"SOD5 is an unprecedented, very powerful antioxidant protein that enables C. albicans to ward off free radicals of the host immune response," said study senior author Valeria Culotta, Ph.D., professor of biochemistry and molecular biology and environmental health sciences at the Johns Hopkins University Bloomberg School of Public Health. Free radicals are highly reactive molecules that can cause oxidative damage.


Contact: Will Sansom
University of Texas Health Science Center at San Antonio

Page: 1

Related medicine news :

1. Kessler Foundation scientists receive Biogen Idec grant to study actual reality in MS
2. Scientists discover a number of novel genetic defects which cause oesophageal cancer
3. Scientists find potential target for treating mitochondrial disorders
4. Scientists describe gut bacteria that cause sepsis in preterm infants
5. Virginia Tech scientists out for blood when it comes to stopping malaria
6. U-M scientists slow development of Alzheimers trademark cell-killing plaques
7. NIH scientists track evolution of a superbug
8. In the lab, scientists coax E. coli to resist radiation damage
9. Let there be tissue-penetrating light: Scientists develop new nanoscale method to fight cancer
10. Scientists discover new protein involved in lung cancer
11. Scientists explore promising new option for first line of attack in lymphoma
Post Your Comments:
(Date:11/27/2015)... CA (PRWEB) , ... November 27, 2015 , ... MPWH, the No.1 Herpes-only dating community ... 30 (see Table 1-1 ). More than 3.7 billion people under the age ... type 1 (HSV-1), according to WHO's first global estimates of HSV-1 infection . , ...
(Date:11/27/2015)... ... November 27, 2015 , ... The moment you stop ... not only fulfilling the needs of advisers and clients but going above and ... providing top-tier customer service. However, there's always room for improvement, which is why ...
(Date:11/27/2015)... ... November 27, 2015 , ... Dr. Thomas Dunlap and ... Dr. Tucker Bierbaum with Emergency Medicine at St., Joseph Health System’s Santa Rosa ... Sepsis conditions present in similar ways and require time-critical intervention to avoid large area ...
(Date:11/26/2015)... ... November 26, 2015 , ... Inevitably when people think Thanksgiving, ... choose to buy during the Black Friday and Cyber Monday massage chair sales ... search the Internet high and low to find the best massage chair deals, they ...
(Date:11/26/2015)... ... November 26, 2015 , ... Jobs in hospital medical laboratories and in the ... healthcare staffing agency Aureus Medical Group . These fields, as well ... those searching for healthcare jobs through the company’s website, , The ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... Calif. , Nov. 25, 2015  Amgen (NASDAQ: ... Biologics License Application (BLA) with the United ... for ABP 501, a biosimilar candidate to Humira ® ... adalimumab biosimilar application submitted to the FDA and represents ... Sean E. Harper , M.D., executive vice ...
(Date:11/25/2015)... WILMINGTON, N.C. , Nov. 25, 2015 /PRNewswire/ ... announces the planned investment of at least $15.8 ... in Wilmington, NC . The ... services capacity to meet the growing demands of ... Wilmington site expansion will provide up ...
(Date:11/25/2015)... , Nov. 25, 2015  Henry Schein, Inc., the ... to office-based dental, medical and animal health practitioners, will ... the Henry Schein ConnectDental® Pavilion , which brings ... of open solutions designed to help any practice or ... here for a schedule of experts appearing at ...
Breaking Medicine Technology: