Navigation Links
Scientists unlock secrets of protein produced by disease-causing fungus
Date:4/16/2014

SAN ANTONIO, Texas (April 16, 2014) A team that includes scientists from the School of Medicine at The University of Texas Health Science Center at San Antonio, Johns Hopkins University and St. Mary's University reported the structure of a protein that helps a common fungus to infect the body.

The fungal pathogen Candida albicans causes yeast infections, diaper rashes and oral thrush, and is the most common fungal pathogen to infect humans. It can also cause a life-threatening infection of the blood called disseminated candidiasis.

"In this study, we determined the three-dimensional structure of a never-before-seen cell wall protein called SOD5 that the organism uses as a defense against the human immune system," said P. John Hart, Ph.D., the Ewing Halsell-President's Council Distinguished Professor of biochemistry at the UT Health Science Center and Research Scientist in the South Texas Veterans Health Care System.

"SOD5 is a copper-only protein that exhibits significant structural differences from copper/zinc superoxide dismutases (SODs)," Dr. Hart said. "Because SOD5 molecules are widespread throughout fungi, including C. albicans, but are not found in humans, the structural differences can be exploited to develop compounds that specifically target SOD5 to treat a number of widespread fungal infections."

Current conventional antifungal treatments such as fluconazole can be toxic to the liver in certain individuals, he noted.

"SOD5 is an unprecedented, very powerful antioxidant protein that enables C. albicans to ward off free radicals of the host immune response," said study senior author Valeria Culotta, Ph.D., professor of biochemistry and molecular biology and environmental health sciences at the Johns Hopkins University Bloomberg School of Public Health. Free radicals are highly reactive molecules that can cause oxidative damage.


'/>"/>

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert

Page: 1

Related medicine news :

1. Kessler Foundation scientists receive Biogen Idec grant to study actual reality in MS
2. Scientists discover a number of novel genetic defects which cause oesophageal cancer
3. Scientists find potential target for treating mitochondrial disorders
4. Scientists describe gut bacteria that cause sepsis in preterm infants
5. Virginia Tech scientists out for blood when it comes to stopping malaria
6. U-M scientists slow development of Alzheimers trademark cell-killing plaques
7. NIH scientists track evolution of a superbug
8. In the lab, scientists coax E. coli to resist radiation damage
9. Let there be tissue-penetrating light: Scientists develop new nanoscale method to fight cancer
10. Scientists discover new protein involved in lung cancer
11. Scientists explore promising new option for first line of attack in lymphoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 22, 2015 Deer Path of Huntley ... Valentine’s Day Happy Hour from 3 p.m. to 4 p.m. on ... Parkway in Huntley, Illinois, serves adults with physical disabilities between the ... include Valentine's Day treats, games and sweetheart-themed karaoke. , For more ...
(Date:1/22/2015)... January 23, 2015 LunaDress, with its top ... fashion industry. Now, the business is showing its latest designs ... dresses. , According to the company’s CEO, all the fresh ... offered with big discounts, up to 80% off. All the ...
(Date:1/22/2015)... Gabe’s Chemo Duck Program is pleased to announce ... ever created for kids with cancer. The Chemo Duck App, available ... filled with enjoyable games to help children of all ages living ... helps to keep kids entertained, educated and at ease while waiting ...
(Date:1/22/2015)... January 22, 2015 The Incredible Bulk is ... Pakulski to increase lean muscle by up to 30lbs in ... the attention of HealthyandFitZone.com’s Stan Stevenson, prompting an investigative review. ... is a step-by-step, scientific diet formula that allows the body ...
(Date:1/22/2015)... the premier women’s dress supplier, has recently released its ... of AngelWeddingDress.com to find more details. , Many ... a bridal party. AngelWeddingDress offers a variety of gorgeous ... wedding dresses are specially designed for 2015. , AngelWeddingDress ...
Breaking Medicine News(10 mins):Health News:Deer Path of Huntley Affordable Assisted Living to Host Valentine's Day Happy Hour 2Health News:LunaDress Shows The Latest Styles Of Wedding Dresses In 2015 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2
... studies has revealed that autism is far more complex than ... the National Institute for Mental Health// , seems to suggest ... 100 different genes. ,It turns out many ... certainly complicates the search for the specific genes contributing to ...
... oncology survey conducted in British Columbia, the cancer care provided ... conducted among 7000 cancer patients by the ministry of health. ... by 97.1% of the people and more than ninety percent ... to wait for a longer time for radiation treatments. ...
... who wear a special kind of no-line bifocal lenses ... a new study published in Investigative Ophthalmology & Visual ... children with two myopic parents, myopia progression was slower ... those wearing single-vision lenses (SVLs).Knowing parental myopia may be ...
... that exposure to phthalates not only causes reproductive problems ... resistance in adult males. This study was conducted by ... research adds to the growing suspicion that low-dose exposures ... testosterone levels or functions in men, and thereby contributing ...
... a major initiative to introduce female condoms across the ... usage study in six districts. ,The central ... the National Aids Control Organisation (NACO) began a nationwide ... Rs.3 to NGOs working with female sex workers. ...
... pressure could certainly be an indicator of one’s happiness. Researchers ... between a nation's overall happiness and its citizens' blood pressure ... people from across the European countries. ,These people were asked ... hypertension (high blood pressure) and so on. ,While ...
Cached Medicine News:Health News:Phthalate Exposure Affects Testosterone Levels and Fertility in Men 2Health News:India to Market Female Condoms 2
(Date:1/23/2015)... GAINESVILLE, Fla. , Jan. 23, 2015  HyGreen, Inc., ... distribution agreement and partnership with RCA Medical, a subsidiary ... Africa . Each year, hundreds of ... health care-associated infections as organisms are transmitted from patient ...
(Date:1/23/2015)... Cord Blood America, Inc. ( www.cordblood-america.com ) (OTC Bulletin Board: ... Preliminary Proxy Statement, Schedule 14A, with the U.S. Securities & ... for shareholders detailing why a "YES" vote to increase the ... As we reflect upon the 2014 fiscal year ...
(Date:1/23/2015)... , Jan. 23, 2015 Gem Pharmaceuticals announced today ... been enrolled into the Company,s Phase 2 clinical trial. ... of Gem,s lead compound, GPX-150 (an investigational medication), in ... metastatic disease. Logo - http://photos.prnewswire.com/prnh/20150123/170966LOGO ...
Breaking Medicine Technology:HyGreen Partners with RCA Medical in Johannesburg, South Africa 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 3Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 4Gem Pharmaceuticals Announces Enrollment of Initial Patients in its Phase 2 Clinical Trial to Assess the Efficacy and Safety of GPX-150 in Sarcoma Patients 2
... , CARTERSVILLE, Ga. ; June 2 ... Women (GASC) – Georgia ,s first fully ... minor gynecological surgeries in a true ... facility specializes in laparoscopic and other highly advanced, ...
... (Nasdaq: FHCO ) announced that it has fulfilled an order for 3.5 million ... World Cup. The 2010 World Cup will take place in The Republic of ... . , , , ... three million tickets to the games, is expected to flood the country with visitors. ...
Cached Medicine Technology:New Georgia Advanced Surgery Center Provides Women Many Unique Benefits 2The Female Health Company Receives Order for 3.5 Million FC2 Female Condoms for Distribution at 2010 World Cup 2The Female Health Company Receives Order for 3.5 Million FC2 Female Condoms for Distribution at 2010 World Cup 3
... Trellis Infusion Catheter enables the physician to ... fluid, and disperse the agent by means ... Trellis is a multi-lumen catheter with two ... and infusion holes located between these balloons. ...
... ACRYSOF® UV-absorbing acrylic foldable single-piece posterior chamber ... of the human crystalline lens in the ... years of age and older. The optical ... soft acrylic material. These lenses have biconvex ...
... All USIOL lenses are manufactured ... and processes. Perspex CQ UV ... the multi-piece and single piece ... available in both nonphaco and ...
Single piece PMMA lens, AC depth: 4.9, 2 suture holes....
Medicine Products: