Navigation Links
Scientists uncover source of ovarian stem-like cells prone to give rise to ovarian cancer
Date:3/7/2013

Cold Spring Harbor, NY In collaboration with colleagues at Cornell University, a team of cancer researchers at Cold Spring Harbor Laboratory (CSHL) has discovered cells with stem-cell properties in the ovary that can mutate to form tumors.

The team demonstrated that when two important tumor suppressor genes are inactivated, a previously unknown subset of ovarian stem-like epithelial cells undergoes cancerous transformation. The findings, published today in the journal Nature, have important implications for our knowledge about ovarian cancer.

"Sources of cells that make ovarian tumors are not really known," says Grigori Enikolopov, Ph.D., one of the co-authors and team leader at CSHL. Dr. Alexander Nikitin is the corresponding author and team leader at Cornel University. "We demonstrated that a stem cell population sits in a portion of the ovary called the hilum, and can repair the ruptures of the ovarian tissue during ovulation, and that these cells are easily transformed into tumor cells," Enikolopov explains.

The idea that cells with stem cell properties can spontaneously mutate to become seeds of cancer has been gaining momentum. Some epithelial cancers such as cancers of the ovary and the intestine are known to originate in the transition regions between different types of epithelial cells, but the exact source of such cells in the ovary has not been defined. Previous findings have suggested that cells in these transition regions may be more "plastic" and exist in a less mature (i.e., less "differentiated") state, making them potential candidates as a cancer source. Until now, however, the lack of direct experimental evidence has made this hypothesis difficult to confirm.

The new work demonstrates that there is a population of slow-proliferating epithelial cells in the mouse ovary that can self-renew and expresses high levels of aldehyde hedydrogenase 1, or ALDH1, a known stem cell marker. The team found that the
'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Defective virus surprisingly plays major role in spread of disease, UCLA life scientists report
2. OHSU scientists first to grow liver stem cells in culture, demonstrate therapeutic benefit
3. Scientists Pinpoint How Deep Brain Stimulation Eases OCD
4. Scientists make older adults less forgetful in memory tests
5. Scientists unveil secrets of important natural antibiotic
6. Fungi offers new clues in asthma fight, say Cardiff scientists
7. Scientists find promising new approach to preventing progression of breast cancer
8. Hopkins scientists create method to personalize chemotherapy drug selection
9. Spanish scientists develop a pioneering technique to effectively treat mucositis
10. Scientists find calcium is the initial trigger in our immune response to healing
11. Scientists should advance management of behavioral norms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... 2014 Recently, LunaDress.co.uk has updated its blog to ... accessories. Now, all of the models at LunaDress.co.uk come with big ... lifts the wedding veil can turn out to be a most ... wedding veil can always bring surprise to a wedding. On the ... to choose veils for a big day . , Going ...
(Date:12/25/2014)... 25, 2014 (HealthDay News) -- The risk of burns ... so you need to be extra cautious, an expert ... see a significant increase in patients coming in with ... Suffolk County Volunteer Firefighters Burn Center of Stony Brook ... be full of joy, but if not careful, could ...
(Date:12/25/2014)... 24, 2014 (HealthDay News) -- Among early stage breast ... than half of one percent will eventually develop leukemia ... reveals. The finding comes from a review of ... and 2007, and it suggests that the risk for ... experts had previously thought. "The frequency of bone ...
(Date:12/25/2014)... December 25, 2014 AngelWeddingDress.com tries its ... the online realm. Today, the business has introduced its ... site-wide prom dress promotion. , The new prom outfits ... and every dress lover. They are specially designed for ... prom dresses should visit its website before Jan. ...
(Date:12/25/2014)... SmileStix ” was featured on NewsWatch as part of its ... on the iOS, Android, and Windows markets. Andrew Tropeano, a ... review and shared with viewers how this is an application ... goes, “A picture says a thousand words.” It’s true. There ... image, because each picture holds a unique and special meaning. ...
Breaking Medicine News(10 mins):Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2Health News:Don't Let Burns Mar Your Holidays 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3Health News:Angelweddingdress 2015 Prom Dresses Online Now 2Health News:An Application to Create Custom Stickers was Featured on NewsWatch Television on December 19, 2014 2
... operated on, or the wrong transplant, study found , , TUESDAY, ... in eye surgery, say U.S. researchers who analyzed 106 cases ... the wrong site or using wrong procedure. , The ... College in New York found: , The most common ...
... Addressing Health Disparities, NASHVILLE, Tenn., Nov. 13 ... grant to the Meharry Medical,College Center for Women,s ... study of health disparities among women of color. ... advance the Center,s work in,addressing diseases that disproportionately ...
... Influenza and Pneumococcal Alert Coalition (CIPAC) and RediClinic, offers Denver, ... help protect themselves and the many ... Center at Aurora during ... this special time of year, - Last year, the 2006-2007 ...
... physician evaluations will have,national impact, NEW YORK, ... Nancy H. Nielsen, M.D., Ph.D., AMA President-elect:, ... New York Attorney General Cuomo has expanded health ... month on,physician ranking programs. Aetna,s decision to join ...
... (PHILADELPHIA) Inappropriate activation of a single enzyme, telomerase, ... in as many as 90 percent of all of ... identified in human tumors, scientists have eyed the enzyme ... drugs. , Now, researchers working at The Wistar ...
... from Wake Forest University Baptist Medical Center suggests that ... kidney transplant and that using donated kidneys that ... burgeoning organ shortage among older adults. , In the ... barrier for both organ donation and transplantation, said Phillip ...
Cached Medicine News:Health News:Eye Surgery Errors Rare But Serious 2Health News:Wal-Mart Foundation Announces $1 Million Grant to the Meharry Medical College Center for Women's Health Research 2Health News:Wal-Mart Foundation Announces $1 Million Grant to the Meharry Medical College Center for Women's Health Research 3Health News:Wal-Mart Foundation Announces $1 Million Grant to the Meharry Medical College Center for Women's Health Research 4Health News:Colorado Influenza and Pneumococcal Alert Coalition (CIPAC) Partners with Novartis Vaccines for Holiday Vaccination Clinic, Making Influenza Vaccination Convenient for Shoppers 2Health News:Colorado Influenza and Pneumococcal Alert Coalition (CIPAC) Partners with Novartis Vaccines for Holiday Vaccination Clinic, Making Influenza Vaccination Convenient for Shoppers 3Health News:Colorado Influenza and Pneumococcal Alert Coalition (CIPAC) Partners with Novartis Vaccines for Holiday Vaccination Clinic, Making Influenza Vaccination Convenient for Shoppers 4Health News:AMA Commends Aetna for Quality First Commitment 2Health News:Telomerase enzyme structure provides significant new target for anti-cancer therapies 2Health News:Telomerase enzyme structure provides significant new target for anti-cancer therapies 3Health News:Higher-risk kidneys may help solve organ shortage facing older adults 2Health News:Higher-risk kidneys may help solve organ shortage facing older adults 3
(Date:12/24/2014)... and RALEIGH, N.C. , ... of Endo International plc (NASDAQ: ENDP ) ... BDSI ) announced today that they have submitted ... Film to the U.S. Food and Drug Administration (FDA).  ... management of pain severe enough to require daily, around-the-clock, ...
(Date:12/22/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/h3xm6q/us ) has ... Glucose Market" report to their offering. ... insight focuses on the developments in the self-monitoring blood ... . Reimbursement analysis and the effects of competitive bidding ... 73 SMBG meters have been performed, based on the ...
(Date:12/22/2014)... STOCKHOLM , Dec. 22, 2014 /PRNewswire/ ... Auxilium Pharmaceuticals, Inc. today announced that the Committee for ... Medicines Agency (EMA) has adopted a positive opinion for ... treatment of adult men with Peyronie,s disease with a ... degrees at the start of therapy. The ...
Breaking Medicine Technology:Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 5US Self-monitoring Blood Glucose Market 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 3Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 4Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 5Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 6
System, English (Continental cord), 230 VAC....
Portable mini halogen light....
Micro-mini fiber optic light....
Miniature high intensity fiber optic light. The ultra-thin fiber-optic cable is smaller and lighter than a standard electrical cord....
Medicine Products: