Navigation Links
Scientists uncover source of ovarian stem-like cells prone to give rise to ovarian cancer
Date:3/7/2013

Cold Spring Harbor, NY In collaboration with colleagues at Cornell University, a team of cancer researchers at Cold Spring Harbor Laboratory (CSHL) has discovered cells with stem-cell properties in the ovary that can mutate to form tumors.

The team demonstrated that when two important tumor suppressor genes are inactivated, a previously unknown subset of ovarian stem-like epithelial cells undergoes cancerous transformation. The findings, published today in the journal Nature, have important implications for our knowledge about ovarian cancer.

"Sources of cells that make ovarian tumors are not really known," says Grigori Enikolopov, Ph.D., one of the co-authors and team leader at CSHL. Dr. Alexander Nikitin is the corresponding author and team leader at Cornel University. "We demonstrated that a stem cell population sits in a portion of the ovary called the hilum, and can repair the ruptures of the ovarian tissue during ovulation, and that these cells are easily transformed into tumor cells," Enikolopov explains.

The idea that cells with stem cell properties can spontaneously mutate to become seeds of cancer has been gaining momentum. Some epithelial cancers such as cancers of the ovary and the intestine are known to originate in the transition regions between different types of epithelial cells, but the exact source of such cells in the ovary has not been defined. Previous findings have suggested that cells in these transition regions may be more "plastic" and exist in a less mature (i.e., less "differentiated") state, making them potential candidates as a cancer source. Until now, however, the lack of direct experimental evidence has made this hypothesis difficult to confirm.

The new work demonstrates that there is a population of slow-proliferating epithelial cells in the mouse ovary that can self-renew and expresses high levels of aldehyde hedydrogenase 1, or ALDH1, a known stem cell marker. The team found that these cells were localized in the ovary's hilum region, where they normally function to repair the ruptured epithelium after ovulation.

The researchers malignantly transformed hilum epithelial cells by shutting off tumor suppressor genes Trp53 and Rb1 and then transplanted these cells into mice. Seven of eight mice developed metastatic ovarian tumors. Trp53 and Rb1 are known to frequently mutate in human ovarian cancers.

"Some broad implications are that similar epithelial transition/junction areas can be the source of stem-like cells susceptible to malignant transformation in other organs, such as the uterine cervix and the esophagus, and become the seeds of cancer there," Enikolopov says. "Now we know what sort of cells to look for."


'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Related medicine news :

1. Defective virus surprisingly plays major role in spread of disease, UCLA life scientists report
2. OHSU scientists first to grow liver stem cells in culture, demonstrate therapeutic benefit
3. Scientists Pinpoint How Deep Brain Stimulation Eases OCD
4. Scientists make older adults less forgetful in memory tests
5. Scientists unveil secrets of important natural antibiotic
6. Fungi offers new clues in asthma fight, say Cardiff scientists
7. Scientists find promising new approach to preventing progression of breast cancer
8. Hopkins scientists create method to personalize chemotherapy drug selection
9. Spanish scientists develop a pioneering technique to effectively treat mucositis
10. Scientists find calcium is the initial trigger in our immune response to healing
11. Scientists should advance management of behavioral norms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2017)... Sacramento, California (PRWEB) , ... September 22, 2017 , ... ... person at a time - carries it into the entertaining and delicious worlds ... year, Matt Gersper (founder of Happy Living) convinced him to turn his play into ...
(Date:9/22/2017)... ... September 22, 2017 , ... “Cursed with ... an obligatory tithe, and the freedom experienced when breaking free from this misconception. ... author, Lysa M. Harrison. , Published by Christian Faith Publishing, Lysa M. Harrison’s ...
(Date:9/22/2017)... ... September 22, 2017 , ... ... emergency rooms is celebrating the one year anniversary of its Houston-Fallbrook facility. ... said Dr. Otinwa, Facility Medical Director of First Choice Emergency Room Houston-Fallbrook. “It ...
(Date:9/22/2017)... ... September 22, 2017 , ... Silicon ... effectively even on the go. Their electric toothbrushes aggressively attack oral bacteria by ... UV sanitizing technology. Combining leading edge Enke technology with a premium timeless design, ...
(Date:9/22/2017)... ... September 22, 2017 , ... “Letters From Home”: ... even the lost, have value to God. “Letters From Home” is the creation of ... member of the President’s Cabinet of Jerry Savelle Ministries International, who has traveled and ...
Breaking Medicine News(10 mins):
(Date:9/12/2017)... SAN FRANCISCO , Sept. 12, 2017 /PRNewswire/ ... Lifecycle Management Solutions (VLMS), is pleased to announce ... as a member of its Board of Directors ... 2017. ValGenesis VLMS enables life science companies to ... eliminate the use of paper in this process. ...
(Date:9/7/2017)... nearly two decades, New Life Agency has been committed to providing the ... Life Agency announces a powerful three-way partnership designed to deliver substantial savings ... ... http://www.schrafts2.com/ (PRNewsfoto/PharmaCareCard) ... http://pharmacarecard.com/ (PRNewsfoto/PharmaCareCard) ...
(Date:9/6/2017)... , Sept. 6, 2017  Robert G. Szewc, M.D., ... Professional Member in recognition of his contributions to the ... as a Nephrologist at the practice of Kidney and ... kidney care and hypertension solutions. He has worked in ... of career experience, as well as expertise in kidneys, ...
Breaking Medicine Technology: