Navigation Links
Scientists uncover source of ovarian stem-like cells prone to give rise to ovarian cancer
Date:3/7/2013

Cold Spring Harbor, NY In collaboration with colleagues at Cornell University, a team of cancer researchers at Cold Spring Harbor Laboratory (CSHL) has discovered cells with stem-cell properties in the ovary that can mutate to form tumors.

The team demonstrated that when two important tumor suppressor genes are inactivated, a previously unknown subset of ovarian stem-like epithelial cells undergoes cancerous transformation. The findings, published today in the journal Nature, have important implications for our knowledge about ovarian cancer.

"Sources of cells that make ovarian tumors are not really known," says Grigori Enikolopov, Ph.D., one of the co-authors and team leader at CSHL. Dr. Alexander Nikitin is the corresponding author and team leader at Cornel University. "We demonstrated that a stem cell population sits in a portion of the ovary called the hilum, and can repair the ruptures of the ovarian tissue during ovulation, and that these cells are easily transformed into tumor cells," Enikolopov explains.

The idea that cells with stem cell properties can spontaneously mutate to become seeds of cancer has been gaining momentum. Some epithelial cancers such as cancers of the ovary and the intestine are known to originate in the transition regions between different types of epithelial cells, but the exact source of such cells in the ovary has not been defined. Previous findings have suggested that cells in these transition regions may be more "plastic" and exist in a less mature (i.e., less "differentiated") state, making them potential candidates as a cancer source. Until now, however, the lack of direct experimental evidence has made this hypothesis difficult to confirm.

The new work demonstrates that there is a population of slow-proliferating epithelial cells in the mouse ovary that can self-renew and expresses high levels of aldehyde hedydrogenase 1, or ALDH1, a known stem cell marker. The team found that these cells were localized in the ovary's hilum region, where they normally function to repair the ruptured epithelium after ovulation.

The researchers malignantly transformed hilum epithelial cells by shutting off tumor suppressor genes Trp53 and Rb1 and then transplanted these cells into mice. Seven of eight mice developed metastatic ovarian tumors. Trp53 and Rb1 are known to frequently mutate in human ovarian cancers.

"Some broad implications are that similar epithelial transition/junction areas can be the source of stem-like cells susceptible to malignant transformation in other organs, such as the uterine cervix and the esophagus, and become the seeds of cancer there," Enikolopov says. "Now we know what sort of cells to look for."


'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Related medicine news :

1. Defective virus surprisingly plays major role in spread of disease, UCLA life scientists report
2. OHSU scientists first to grow liver stem cells in culture, demonstrate therapeutic benefit
3. Scientists Pinpoint How Deep Brain Stimulation Eases OCD
4. Scientists make older adults less forgetful in memory tests
5. Scientists unveil secrets of important natural antibiotic
6. Fungi offers new clues in asthma fight, say Cardiff scientists
7. Scientists find promising new approach to preventing progression of breast cancer
8. Hopkins scientists create method to personalize chemotherapy drug selection
9. Spanish scientists develop a pioneering technique to effectively treat mucositis
10. Scientists find calcium is the initial trigger in our immune response to healing
11. Scientists should advance management of behavioral norms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... ... February 09, 2016 , ... Center for Autism and Related ... autism spectrum disorder (ASD). Beginning Jan. 1, 2016, Medicaid is covering autism treatment ... is key to providing effective treatment for individuals with ASD. Now, over 1,800 ...
(Date:2/9/2016)... ... February 09, 2016 , ... Cirracore Enterprise Cloud, ... move workloads to the cloud. Cirracore provides a secure VMware® vCloud Air ... the Internet. Transformation Solutions (TSL Partners) provides a full range of services ...
(Date:2/9/2016)... ... ... Journal of Pain Research has published the commentary “ Terminology of chronic ... John F. Peppin says “Terminology matters, yet little attention has been paid to the ... pain’ and ‘chronic non-cancer pain’ are replete in the literature; however, the distinction here ...
(Date:2/9/2016)... (PRWEB) , ... February 09, 2016 , ... ... therapy products, announced today the introduction of the newly designed, innovative shoulder wrap. ... and better cold therapy coverage for the injured arm and shoulder to promote ...
(Date:2/9/2016)... ... 2016 , ... Shark Finds and Kevin Harrington, and the Product Managers of AsSeenOnTV.pro ... is a newly patented product that has solved some of the basic problems golfers have ... morning dew or right after a rain shower, might understand the struggle of placing the ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... -- Hearing protection devices refer to the barriers that ... inner ear. Hearing protection devices include earplugs, uniform attenuation ... for users exposed to noise levels of over 80 ... are inserted in the ear canal to protect the ... natural sound perception with the help of acoustic filters. ...
(Date:2/9/2016)... Calif. , Feb. 9, 2016  Increasingly, health ... monitoring their vital signs with wireless technology. With the ... can automate patient oversight and remotely detect problems before ... vital signs across in-hospital environments. the ... the United States . --> ...
(Date:2/9/2016)... new report "Global Anti-Bacterial Drugs Market Assessment & Forecast: 2015 - ... the North America continued to lead global ... translated into revenues worth US$ 16,907.3 million. ... Asia-Pacific , Latin America , ... anti-bacterial market is inclined towards North America ...
Breaking Medicine Technology: