Navigation Links
Scientists uncover protective mechanism against liver cancer
Date:12/14/2009

A team of scientists from the UC San Diego School of Medicine and Osaka University in Japan have identified a protein switch that helps prevent liver damage, including inflammation, fibrosis and cancer. The findings suggest that a better understanding of how the protein, TAK1, works could lead to new insights into the development of liver disease and cancer.

"TAK1 appears to be a master regulator of liver function," said David A. Brenner, MD, professor of medicine and Dean of the UC San Diego School of Medicine. He and Ekihiro Seki, MD, PhD, assistant research scientist in the Department of Medicine, led the work. "Understanding its role in liver disease and cancer may eventually enable us to devise new therapeutic strategies." Their study appears on line the week of December 14 in advance of publication in the journal Proceedings of the National Academy of Sciences.

TAK1 is a kinase, a type of signaling protein involved in regulating various cell activities, including cell growth. Researchers have known that TAK1 activates two specific proteins, NF-kappaB and JNK, which are both involved in immunity, inflammation, programmed cell death and cancer. But NF-kappaB helps protect liver cells from dying and protects against cancer development. In contrast, JNK promotes cell death and cancer.

However, it has been unclear whether TAK1 promotes or prevents the development of liver cancer. To find out, Seki, Brenner and their group created a mouse model in which liver cells lacked the gene Tak1, which makes the TAK1 protein. In a series of experiments, they found a high rate of liver cell death in young animals lacking TAK1. The animals' livers then went into overdrive, producing too many liver cells to make up for the loss and causing liver damage, including inflammation and fibrosis liver scarring and eventually, cancer.

According to Seki, the study is the first to demonstrate the role of TAK1 in cancer development, and strongly suggests that the protein also contributes to cancer development in other organs. In addition, the liver cancer mouse model that the team developed is associated with sustained liver inflammation and fibrosis key features of human liver cancer and should be useful in investigating whether fibrosis influences liver cancer development.

"We can also use the model to test whether a potential cancer drug or therapy affects both fibrosis and cancer, or either one," Seki said. "This study will open a new therapeutic potential targeting the expression of TAK1 for liver cancer."


'/>"/>

Contact: Steve Benowitz
sbenowitz@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related medicine news :

1. UNC scientists coordinate study of link between insulin use and cancer in people with diabetes
2. Doctors and Scientists Create New Society to Promote Non-Animal Toxicology Testing Methods
3. NeuroFocus Adds Two More of the Worlds Leading Neuroscientists to its Advisory Board
4. Scripps Research scientists reveal key structure from ebola virus
5. Stand Up To Cancer Funds High-risk/High-reward Cancer Research by 13 Young Scientists
6. Caltech scientists show how ubiquitin chains are added to cell-cycle proteins
7. Vanderbilt scientists report first effective medical therapy for rare stomach disorder
8. Childrens Hospital Oakland scientists discover soy component may be key to fighting colon cancer
9. BIDMC scientists awarded grants from Michael J. Fox Foundation for Parkinsons research
10. Scientists find molecular trigger that helps prevent aging and disease
11. Chinese Scientists Develop Database on the Liver
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... Shelton, CT (PRWEB) , ... October 13, 2017 , ... ... and long-term care services, staged a mock evacuation of the facility as part of ... Department, Shelton Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well ...
(Date:10/13/2017)... Milford, NJ (PRWEB) , ... October 13, 2017 , ... ... weekend at scenic Alexandria Park in Milford, NJ. This free event, sponsored by ... and physical activity. The fun run is geared towards children of all ages; ...
(Date:10/13/2017)... ... , ... “The Journey: From the Mountains to the Mission Field”: the story ... the Philippines. “The Journey: From the Mountains to the Mission Field” is the creation ... has taught all ages and currently teaches a class of ladies at her church, ...
(Date:10/12/2017)... New Orleans, LA (PRWEB) , ... October 12, 2017 , ... ... fitness centers in the U.S., announced today its plans to open a flagship location ... club will occupy the former Rooms To Go store next to Office Depot in ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... leader in post-acute health care, have expanded their existing home health joint venture ... , AccentCare has been operating a joint venture home health company with Asante, ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... , Sept. 19, 2017   ZirMed Inc ., ... analytics, today announced that it has been ranked #1 by ... Black Book™ Rankings 2017 User Survey. ZirMed was recognized ... for large hospitals and medical centers over 200 beds and ... Book,s healthcare technology user survey history. ...
(Date:9/18/2017)... , Sept. 18, 2017 ... fields of bioinformatics and immune engineering, today ... protective avian influenza A (H7N9) vaccine. ... related to seasonal influenza and presents a ... on prior exposure to be effective. Using ...
(Date:9/12/2017)... 12, 2017   EcoVadis , the leading platform for environmental, social ... annual edition of its Global CSR Risk and Performance Index. The report ... based on Scorecard Ratings that analyzed nearly 800,000 data points across the ... ... ...
Breaking Medicine Technology: