Navigation Links
Scientists uncover protective mechanism against liver cancer
Date:12/14/2009

A team of scientists from the UC San Diego School of Medicine and Osaka University in Japan have identified a protein switch that helps prevent liver damage, including inflammation, fibrosis and cancer. The findings suggest that a better understanding of how the protein, TAK1, works could lead to new insights into the development of liver disease and cancer.

"TAK1 appears to be a master regulator of liver function," said David A. Brenner, MD, professor of medicine and Dean of the UC San Diego School of Medicine. He and Ekihiro Seki, MD, PhD, assistant research scientist in the Department of Medicine, led the work. "Understanding its role in liver disease and cancer may eventually enable us to devise new therapeutic strategies." Their study appears on line the week of December 14 in advance of publication in the journal Proceedings of the National Academy of Sciences.

TAK1 is a kinase, a type of signaling protein involved in regulating various cell activities, including cell growth. Researchers have known that TAK1 activates two specific proteins, NF-kappaB and JNK, which are both involved in immunity, inflammation, programmed cell death and cancer. But NF-kappaB helps protect liver cells from dying and protects against cancer development. In contrast, JNK promotes cell death and cancer.

However, it has been unclear whether TAK1 promotes or prevents the development of liver cancer. To find out, Seki, Brenner and their group created a mouse model in which liver cells lacked the gene Tak1, which makes the TAK1 protein. In a series of experiments, they found a high rate of liver cell death in young animals lacking TAK1. The animals' livers then went into overdrive, producing too many liver cells to make up for the loss and causing liver damage, including inflammation and fibrosis liver scarring and eventually, cancer.

According to Seki, the study is the first to demonstrate the role of TAK1 in cancer development, and
'/>"/>

Contact: Steve Benowitz
sbenowitz@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UNC scientists coordinate study of link between insulin use and cancer in people with diabetes
2. Doctors and Scientists Create New Society to Promote Non-Animal Toxicology Testing Methods
3. NeuroFocus Adds Two More of the Worlds Leading Neuroscientists to its Advisory Board
4. Scripps Research scientists reveal key structure from ebola virus
5. Stand Up To Cancer Funds High-risk/High-reward Cancer Research by 13 Young Scientists
6. Caltech scientists show how ubiquitin chains are added to cell-cycle proteins
7. Vanderbilt scientists report first effective medical therapy for rare stomach disorder
8. Childrens Hospital Oakland scientists discover soy component may be key to fighting colon cancer
9. BIDMC scientists awarded grants from Michael J. Fox Foundation for Parkinsons research
10. Scientists find molecular trigger that helps prevent aging and disease
11. Chinese Scientists Develop Database on the Liver
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/3/2015)... ... ... Hope Food Bank will hopefully be getting a large donation of canned food items ... Greenville SC are making it their mission to collect as many canned items as possible. ... from the public as well. As part of the canned food drive, these local chiropractors ...
(Date:7/3/2015)... ... ... Scientists at several top US cancer centers believe they now know why certain people ... read the complete story , just posted on the Surviving Mesothelioma website. , ... York University exposed mice with a mutation on the tumor suppressor gene called BAP1 ...
(Date:7/3/2015)... , ... July 03, 2015 , ... ... took place on June 25, 2015 at 1:00pm. The Association welcomed speaker C. ... pertaining to injured bicyclists and practical points of investigating these types of cases. ...
(Date:7/3/2015)... ... ... First Choice Emergency Room , the largest network of independent freestanding emergency ... Director of its Frisco facility. , “We are pleased to announce that Dr. Manzanares ... Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. Manzanares received ...
(Date:7/3/2015)... ... ... Celebrity Dresses is currently running a promotion through July 30th. Anyone who orders party ... get 10% discount on orders that are over $100. , The promotion is automatically ... or remember redemption codes. , There is a low price guarantee at The ...
Breaking Medicine News(10 mins):Health News:Greenville Area AlignLife Offices to do a Thanksgiving in July Food Drive 2Health News:Greenville Area AlignLife Offices to do a Thanksgiving in July Food Drive 3Health News:Study Finds Small Amounts of Asbestos May Trigger Mesothelioma in People with Genetic Mutation, According to Surviving Mesothelioma 2Health News:Attorney from William Mattar Leads Discussion on Bicycle Accidents 2Health News:First Choice Emergency Room Announces Dr. Mariah N. Manzanares as Medical Director of Frisco, TX Facility 2Health News:First Choice Emergency Room Announces Dr. Mariah N. Manzanares as Medical Director of Frisco, TX Facility 3Health News:Celebrity Fashion Summer Party Dresses on sale at TheCelebrityDresses.com 2
... endpoints , , VALENCIA, Calif., Dec. 4 ... announced that it has met the primary endpoints of its final two ... insulin product. The company expects to disclose more details of the top-line ... diabetes (studies 030 and 102) by mid-December. , ...
... bring sports flavor to the conversation about a serious men,s ... CARY, N.C., Dec. 4 College basketball analyst and sports ... Interruption Michael Wilbon have teamed up with ESPN, The V ... an effort to create a national discussion about the often ...
... Dec. 4 Nu Skin Enterprises, Inc.,(NYSE: NUS ... its,annual Investor Day presentation this morning at 9 a.m. at ... presentation, senior,management will discuss the company,s operational results and outline ... Nu Skin business is on track and we look forward ...
... 4 The Ensign Group, Inc.,(Nasdaq: ENSG ... skilled nursing,rehabilitative care services and assisted living companies, announced ... Alta, an 85-bed skilled,nursing facility in Salt Lake City, ... Center. , (Logo: ...
... less than half of patients with necrotizing soft tissue ... infections, researchers have found two simple blood tests can ... bacteria," according to a study in the December issue ... Researchers at the Los Angeles Biomedical Research Institute at ...
... ProVet , a multi-function patient monitor, provides veterinarians with superior monitoring ... ... (Vocus) December 4, 2008 -- DRE Veterinary — a premier ... Waveline ProVet , a lightweight vital signs monitor that displays as ...
Cached Medicine News:Health News:MannKind Reports Positive Results from Final Two Pivotal Phase 3 Clinical Studies in Type 1 and Type 2 Diabetes 2Health News:MannKind Reports Positive Results from Final Two Pivotal Phase 3 Clinical Studies in Type 1 and Type 2 Diabetes 3Health News:ESPN's Dick Vitale and Michael Wilbon Stand Up in the Fight Against Prostate Cancer 2Health News:ESPN's Dick Vitale and Michael Wilbon Stand Up in the Fight Against Prostate Cancer 3Health News:ESPN's Dick Vitale and Michael Wilbon Stand Up in the Fight Against Prostate Cancer 4Health News:Nu Skin Enterprises Offers 2009 Guidance During Annual Investor Day 2Health News:Nu Skin Enterprises Offers 2009 Guidance During Annual Investor Day 3Health News:The Ensign Group, Inc. Acquires Utah Skilled Nursing Facility 2Health News:Blood tests can help detect presence of necrotizing soft tissue infections 2Health News:DRE Veterinary Introduces Dynamic Flat Panel Monitor 2Health News:DRE Veterinary Introduces Dynamic Flat Panel Monitor 3Health News:DRE Veterinary Introduces Dynamic Flat Panel Monitor 4
(Date:7/3/2015)... 4, 2015 A global continuing ... diabetes and thyroid disorders in Central and ... and a major conference dedicated to these diseases. ... Diabetes Online , Manage Hypertension Online and ... operated by EXCEMED - combine the world,s ...
(Date:7/3/2015)... , July 3, 2015 ... bekannt, vorbehaltlich bestimmter Abschlussbedingungen eine 100-prozentige Beteiligung ... zu haben. Mit dieser Übernahme dringt Lupin ... einem Umsatz von 765 Mrd. RUB im ... der Welt gehörte (IMS Health). Seit über ...
(Date:7/2/2015)... 2015 BGI a annoncé aujourd,hui que ... l,ADN situé à Hong Kong ... of Pathologists  (Collège des pathologistes américains, ou CAP). ... Kong constituent le premier laboratoire clinique ... certification du CAP en Chine, car il satisfait ...
Breaking Medicine Technology:Combating Three Major Chronic Diseases in Central and South-East Asia With Medical Education 2Lupin übernimmt Biocom aus Russland 2Lupin übernimmt Biocom aus Russland 3BGI obtient la certification du Collège des pathologistes américains (CAP) 2
... www.ecardio.com ) announces three executive appointments in an effort to ... patients they serve. "The continued growth that eCardio ... an opportunity to expand the roles of three members of ... Executive Officer. Robert Jordan, Executive Vice President, will ...
... 2011 Inovio Pharmaceuticals, Inc. (NYSE Amex: ... and preventive vaccines against cancers and infectious diseases, announced ... and electroporation delivery technology at the 14th Annual Meeting ... to be held May 18-21 in Seattle, Washington at ...
Cached Medicine Technology:Inovio Pharmaceuticals to Present at American Society of Gene & Cell Therapy Annual Meeting May 18 - 21, 2011 2Inovio Pharmaceuticals to Present at American Society of Gene & Cell Therapy Annual Meeting May 18 - 21, 2011 3Inovio Pharmaceuticals to Present at American Society of Gene & Cell Therapy Annual Meeting May 18 - 21, 2011 4
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: