Navigation Links
Scientists uncover protective mechanism against liver cancer
Date:12/14/2009

A team of scientists from the UC San Diego School of Medicine and Osaka University in Japan have identified a protein switch that helps prevent liver damage, including inflammation, fibrosis and cancer. The findings suggest that a better understanding of how the protein, TAK1, works could lead to new insights into the development of liver disease and cancer.

"TAK1 appears to be a master regulator of liver function," said David A. Brenner, MD, professor of medicine and Dean of the UC San Diego School of Medicine. He and Ekihiro Seki, MD, PhD, assistant research scientist in the Department of Medicine, led the work. "Understanding its role in liver disease and cancer may eventually enable us to devise new therapeutic strategies." Their study appears on line the week of December 14 in advance of publication in the journal Proceedings of the National Academy of Sciences.

TAK1 is a kinase, a type of signaling protein involved in regulating various cell activities, including cell growth. Researchers have known that TAK1 activates two specific proteins, NF-kappaB and JNK, which are both involved in immunity, inflammation, programmed cell death and cancer. But NF-kappaB helps protect liver cells from dying and protects against cancer development. In contrast, JNK promotes cell death and cancer.

However, it has been unclear whether TAK1 promotes or prevents the development of liver cancer. To find out, Seki, Brenner and their group created a mouse model in which liver cells lacked the gene Tak1, which makes the TAK1 protein. In a series of experiments, they found a high rate of liver cell death in young animals lacking TAK1. The animals' livers then went into overdrive, producing too many liver cells to make up for the loss and causing liver damage, including inflammation and fibrosis liver scarring and eventually, cancer.

According to Seki, the study is the first to demonstrate the role of TAK1 in cancer development, and strongly suggests that the protein also contributes to cancer development in other organs. In addition, the liver cancer mouse model that the team developed is associated with sustained liver inflammation and fibrosis key features of human liver cancer and should be useful in investigating whether fibrosis influences liver cancer development.

"We can also use the model to test whether a potential cancer drug or therapy affects both fibrosis and cancer, or either one," Seki said. "This study will open a new therapeutic potential targeting the expression of TAK1 for liver cancer."


'/>"/>

Contact: Steve Benowitz
sbenowitz@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related medicine news :

1. UNC scientists coordinate study of link between insulin use and cancer in people with diabetes
2. Doctors and Scientists Create New Society to Promote Non-Animal Toxicology Testing Methods
3. NeuroFocus Adds Two More of the Worlds Leading Neuroscientists to its Advisory Board
4. Scripps Research scientists reveal key structure from ebola virus
5. Stand Up To Cancer Funds High-risk/High-reward Cancer Research by 13 Young Scientists
6. Caltech scientists show how ubiquitin chains are added to cell-cycle proteins
7. Vanderbilt scientists report first effective medical therapy for rare stomach disorder
8. Childrens Hospital Oakland scientists discover soy component may be key to fighting colon cancer
9. BIDMC scientists awarded grants from Michael J. Fox Foundation for Parkinsons research
10. Scientists find molecular trigger that helps prevent aging and disease
11. Chinese Scientists Develop Database on the Liver
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... (PRWEB) , ... February 05, 2016 , ... Steven Tonkinson, ... he has completed every year since it started in 2003. This year, he ran ... attention of fellow runners and NBA team the Miami Heat. , This Sunday, while ...
(Date:2/5/2016)... ... February 05, 2016 , ... Today, the Whole-Food Warrior TV show, ... much-anticipated feature with author Jahnavi Foster, specialist in healthy vegetarian cuisine, will stream on ... week, on his weekly Whole-Food Warrior TV show, Frank Davis highlights Whole-Food Warriors - ...
(Date:2/5/2016)... ... 05, 2016 , ... The Muscular Dystrophy Association and Sailormen ... the 14th annual “Appetite for a Cure” campaign on Feb. 1 to raise ... related diseases that severely limit strength and mobility. , Now through March ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... George H. Van Allen have signed a joint enrollment and degree completion agreement. ... pathway toward associate and baccalaureate degrees at FHU|Dickson. , The agreement allows ...
(Date:2/5/2016)... ... 2016 , ... US Sports Camps , official operators of Nike Yoga ... kids yoga training. ChildLight Yoga Studio is centrally situated in the picturesque New England ... Yoga Studio founder Lisa Flynn expresses her excitement, “We are thrilled to be partnering ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... Wegener Polyangiitis - Pipeline Review, H2 ... Polyangiitis - Pipeline Review, H2 2015, provides an ... This report provides comprehensive information on the therapeutic ... at various stages, therapeutics assessment by drug target, ... and molecule type, along with latest updates, and ...
(Date:2/4/2016)... Frontier Pharma: Chronic Obstructive Pulmonary Disease ... Chronic Obstructive Pulmonary Disease (COPD) is ... the airways and lungs. Persistent breathing difficulties and ... one of the leading causes of morbidity and ... COPD is linked to cumulative exposure to risk ...
(Date:2/4/2016)... 2016 In response to the opioid abuse epidemic, ... for Medical Products and Tobacco, along with other FDA leaders, ... approach to opioid medications. The plan will focus on policies ... pain access to effective relief. --> ... Re-examine the risk-benefit paradigm for opioids and ensure that the ...
Breaking Medicine Technology: