Navigation Links
Scientists uncover multiple faces of deadly breast cancer
Date:4/4/2012

An international team of scientists, including four at Simon Fraser University, has made a discovery that will change the way the most deadly form of breast cancer is treated.

The journal Nature has just published the team's findings online in the paper The clonal and mutational evolution spectrum of primary triple negative breast cancers.

The study is the largest genetic analysis of what were thought to be triple negative breast cancer tumours.

The 59 scientists involved in this study expected to see similar gene profiles when they mapped on computer the genomes of 100 tumours.

But to their amazement they found no two genomes were similar, never mind the same. "Seeing these tumours at a molecular level has taught us we're dealing with a continuum of different types of breast cancer here, not just one," explains Steven Jones, co-author of this study.

The SFU molecular biology and biochemistry professor, who heads up bioinformatics research at the BC Cancer Agency, adds: "The genetic diversity of these tumours, even though they're clinically similar, probably explains why they are so difficult to treat. These findings prove the importance of personalizing cancer drug treatment so that it targets the genetic make up of a particular tumour rather than presuming one therapy can treat multiple, similar-looking tumours."

Triple negative breast cancer lacks surface cell receptors for estrogen, progesterone and herceptin a hormone, steroid and protein, respectively, linked to breast cancer. It strikes 16 per cent of women who develop breast cancer and targets mainly those under age 40.

Scientists consider it the most deadly form of breast cancer because it doesn't respond well to modern drug therapies, which knock out receptors found in most breast cancers but not this one.

Typically, triple negative breast cancer patients need everything thrown at them surgery, chemotherapy and radiation to have any hope of going into remission.

Jones credits the affordability of genetic sequencing a process that now takes tens of thousands rather than millions of dollars to do with making tumour analysis at the molecular level more readily available.


'/>"/>

Contact: Carol Thorbes
cthorbes@sfu.ca
778-782-3035
Simon Fraser University
Source:Eurekalert

Related medicine news :

1. Scientists solving the mystery of human consciousness
2. A*STAR scientists discover special class of natural fats stimulates immune cells to fight diseases
3. Hutchinson Center and TGen scientists discover potential break through in pancreatic cancer
4. Scientists study link between amyloid beta peptide levels and Alzheimers disease
5. Scientists measure how energy is spent in martial arts
6. Scientists link 2 cancer-promoting pathways in esophageal cancer
7. Hutchinson Center scientists break through pancreas cancer treatment barrier
8. Sanford-Burnham scientists unravel cancer drugs secret to resistance
9. Scientists develop a software tool for estimating heart disease risk
10. UCLA scientists uncover mechanism for melanoma drug resistance
11. No workout? No worries: Scientists prevent muscle loss in mice, despite disease and inactivity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... April 29, 2016 , ... In an article ... divorcee, shares her enthusiasm for Botox and lip injections, which she underwent in order ... oriented Coachella Valley Music and Arts Festival. The article explains that Ms. Mirmelli’s situation ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... announces the addition Onnit brand Alpha BRAIN and New Mood Daily-Stress Formula for ... and mood optimization products to the store is just one more way Shamangelic ...
(Date:4/29/2016)... ... April 29, 2016 , ... The American workforce ... stability, even security. Most importantly, employees are the single most important asset in ... workers so unhappy? , Just under half of American workers are emotionally checked ...
(Date:4/29/2016)... , ... April 29, 2016 , ... Conditions were ideal ... Cove Island Park on Sunday, with sunny skies, a light breeze and temperatures in ... $33,000. , The 5k Run and Walk and 1-mile walk were held ...
(Date:4/29/2016)... ... ... Spine Team Texas, a comprehensive spine physician group specializing in the treatment ... been invited to be a featured speaker at the Texas Society of the American ... 2016. , Dr. R. Scott McPherson, a physical medicine and rehabilitation specialist, will ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... -- Treato , the single largest ... that it has been named a Cool Vendor by ... Sciences, 2016, Stephen Davies , Michael ... life-science- oriented analytics, algorithms and smart machine technology in ... medication ingestion, and analyze unstructured information.   ...
(Date:4/28/2016)... 28, 2016   Acsis , a leading provider ... IT market research and advisory firm IDC has named ... MarketScape: Worldwide Pharmaceutical Track and Trace Software 2016 Vendor ... an assessment of the capabilities and business strategies of ... market. Logo - http://photos.prnewswire.com/prnh/20160427/360791LOGO ...
(Date:4/27/2016)... MARLBOROUGH, Mass., April 27, 2016  Hologic, Inc. ... Company,s financial results for the fiscal second quarter ... share (EPS) of $0.24 increased 41.2%, and non-GAAP ... $693.3 million increased 5.8% on a reported basis, ... "We posted another good quarter, highlighted ...
Breaking Medicine Technology: