Navigation Links
Scientists uncover multiple faces of deadly breast cancer
Date:4/4/2012

An international team of scientists, including four at Simon Fraser University, has made a discovery that will change the way the most deadly form of breast cancer is treated.

The journal Nature has just published the team's findings online in the paper The clonal and mutational evolution spectrum of primary triple negative breast cancers.

The study is the largest genetic analysis of what were thought to be triple negative breast cancer tumours.

The 59 scientists involved in this study expected to see similar gene profiles when they mapped on computer the genomes of 100 tumours.

But to their amazement they found no two genomes were similar, never mind the same. "Seeing these tumours at a molecular level has taught us we're dealing with a continuum of different types of breast cancer here, not just one," explains Steven Jones, co-author of this study.

The SFU molecular biology and biochemistry professor, who heads up bioinformatics research at the BC Cancer Agency, adds: "The genetic diversity of these tumours, even though they're clinically similar, probably explains why they are so difficult to treat. These findings prove the importance of personalizing cancer drug treatment so that it targets the genetic make up of a particular tumour rather than presuming one therapy can treat multiple, similar-looking tumours."

Triple negative breast cancer lacks surface cell receptors for estrogen, progesterone and herceptin a hormone, steroid and protein, respectively, linked to breast cancer. It strikes 16 per cent of women who develop breast cancer and targets mainly those under age 40.

Scientists consider it the most deadly form of breast cancer because it doesn't respond well to modern drug therapies, which knock out receptors found in most breast cancers but not this one.

Typically, triple negative breast cancer patients need everything thrown at them surgery, chemotherapy and radiation to have any hope of going into remission.

Jones credits the affordability of genetic sequencing a process that now takes tens of thousands rather than millions of dollars to do with making tumour analysis at the molecular level more readily available.


'/>"/>

Contact: Carol Thorbes
cthorbes@sfu.ca
778-782-3035
Simon Fraser University
Source:Eurekalert

Related medicine news :

1. Scientists solving the mystery of human consciousness
2. A*STAR scientists discover special class of natural fats stimulates immune cells to fight diseases
3. Hutchinson Center and TGen scientists discover potential break through in pancreatic cancer
4. Scientists study link between amyloid beta peptide levels and Alzheimers disease
5. Scientists measure how energy is spent in martial arts
6. Scientists link 2 cancer-promoting pathways in esophageal cancer
7. Hutchinson Center scientists break through pancreas cancer treatment barrier
8. Sanford-Burnham scientists unravel cancer drugs secret to resistance
9. Scientists develop a software tool for estimating heart disease risk
10. UCLA scientists uncover mechanism for melanoma drug resistance
11. No workout? No worries: Scientists prevent muscle loss in mice, despite disease and inactivity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... ... January 18, 2017 , ... At Hallmark Nameplate, their ... that they have achieved certification to ISO 13485. This certification is another way they ... to date products and services that they need. , The ISO 13485 Certification is ...
(Date:1/18/2017)... ... January 18, 2017 , ... The Hear the ... project with the donation of cochlear implants. In February 2017, the first three ... a fair chance of leading an independent life. This engagement builds on the ...
(Date:1/17/2017)... (PRWEB) , ... January 17, 2017 , ... January is National Stalking Awareness Month ... choose to lurk in the corners and commit the crime of stalking, a very real ... and addiction, an often overlooked factor in stalking and other crimes. , “Stalking: know it. ...
(Date:1/17/2017)... ... , ... For breast cancer clinicians and researchers who were unable to attend ... intimate review and analysis of its highlights, a novel half-day, complimentary meeting—the 14th Annual ... on February 4, 2017 in Chicago. Chaired by Kathy S. Albain, MD, FACP, FASCO ...
(Date:1/17/2017)... ... January 17, 2017 , ... Kevin Harrington (one of the original Sharks from ... campaigns regarding the topic of Beauty and Personal Care. , Everyone ... better way to commit to these changes than beginning with personal care and beauty ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... SAN DIEGO , Jan. 18, 2017 /PRNewswire/ ... manufacturing solutions for cell and advanced therapies , ... the French biopharmaceutical company developing "tumor starvation" treatments ... unmet medical needs. Under the agreement, Invetech will ... products based on Erytech,s proprietary ERYCAPS technology platform, ...
(Date:1/18/2017)... January 18, 2017 After the recent ... the use of cannabis both for medical and recreational purposes ... Americans open to the use of cannabis, but the focus ... to Arcview Market Research, the North American legal cannabis market ... the previous year. The research projects sales will grow at ...
(Date:1/17/2017)... 2017 North America Insulin Delivery Market Outlook ... America Insulin Delivery Market Outlook to 2022", provides key ... The report provides value, in millions of US dollars, ... segments - Insulin Pens, Insulin Pumps, Insulin Syringes and ... company shares and distribution shares data for each of ...
Breaking Medicine Technology: