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Scientists uncover key piece to cancer cell survival puzzle
Date:8/7/2014

ther tumor types," according to Professor Baird.

"Thus, the discovery that Ligase 3 is required for this process is fundamentally important," he adds.

Interestingly, the research was made possible by a chance meeting between Cardiff's Professor Baird and Professor Eric Hendrickson from the University of Minnesota at an international conference.

The pair quickly discovered they were both looking at the role of Ligase 3 in cancer, they decided to collaborate.

"The collaboration paid off as we were able to uncover something that neither one of us could have done on our own," Professor Hendrickson says.

Importantly, additional studies are already underway. In particular, the reliance on Ligase 3 appears, in turn, to be dependent upon the activity of another key DNA repair gene, p53.

"Since p53 is the most commonly mutated gene in human cancer, it now behooves us to discover how these two genes are interacting and to see if we can't use that information to develop synergistic treatment modalities," added Professor Hendrickson.


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Contact: Chris Jones
jonesc83@cardiff.ac.uk
029-208-74731
Cardiff University
Source:Eurekalert

Page: 1 2

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