Navigation Links
Scientists to investigate preventing life-threatening complications in transplant patients
Date:8/20/2012

Scientists from the University of Southampton have received a grant from the blood cancer charity Leukaemia & Lymphoma Research to explore ways of preventing life-threatening side effects in patients receiving bone marrow transplants.

The team, led by Aymen Al-Shamkhani a Professor of Immunology, has received 270,000 for the three-year project to improve transplants, which often offer a last chance of a cure for patients with many different types of blood cancer.

When transplanted, donor bone marrow helps to replenish a healthy blood supply, repairing damage caused by chemotherapy. Among the blood cells transplanted are T-cells, white blood cells crucial to the body's immune system that recognise alien cells and fight infection. In a process called graft-vs-leukaemia (GVL), these new T-cells hunt down any malignant leukaemia cells that have survived chemotherapy.

However, in many cases when the donor and patient are not an exact genetic match, donor T-cells also recognise healthy cells as 'foreign'. The new immune system fights the patient's body in a complication called graft-vs-host disease (GVHD). This occurs in around half of all bone marrow transplants and can be life-threatening and cause long-term health problems.

One way to reduce the chances of developing GVHD is to remove T-cells from the donor bone marrow at the time of the transplant and providing them a later transfusion.

However, delaying the introduction of T-cells reduces the vital GVL effect, creating a high risk of the blood cancer relapsing.

Prof Al-Shamkhani's team will address these problems by investigating ways to stimulate donor T-cells so that they only target the cancerous cells and don't get worn out, thus making the T-cells more effective at fighting the cancer while reducing the chances of GVHD.

Prof Al-Shamkhani said: "Recent research has provided some indication of ways in which GVHD can be prevented, although often the delayed introduction of the T-cells has led to relapse. By gaining a better understanding of the mechanisms of the disease and the way T-cells fight blood cancer, we hope to be able to design treatments that can deliver the best possible chances of survival."

Professor Chris Bunce, Research Director at Leukaemia & Lymphoma Research, said: "GVHD in blood cancer transplants is a major side-effect and often leads to serious health problems, even if the original disease had been destroyed. The potential benefits of this project could go beyond blood cancers, as GVHD can occur in many transplants."


'/>"/>
Contact: Becky Attwood
r.attwood@soton.ac.uk
44-023-805-95457
University of Southampton
Source:Eurekalert

Related medicine news :

1. Scientists solving the mystery of human consciousness
2. Scientists uncover multiple faces of deadly breast cancer
3. Scientists identify major source of cells defense against oxidative stress
4. Scientists tailor cell surface targeting system to hit organelle ZIP codes
5. Scientists rewrite rulebook on breast cancer in landmark global study
6. Warwick scientists uncover how checkpoint proteins bind chromosomes
7. NIH scientists link quickly spreading gene to Asian MRSA epidemic
8. Joslin scientists identify important mechanism that affects the aging process
9. Scripps Research scientists show how memory B cells stay in class to fight different infections
10. Scientists Map Melanomas Genome
11. A*STAR scientists discover switch to boost anti-viral response to fight infectious diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... D.C. (PRWEB) , ... June 25, 2016 , ... ... discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, ... their work on several important health care topics including advance care planning, healthcare ...
(Date:6/25/2016)... ... , ... First Choice Emergency Room , the largest network of independent ... Director of its new Mesquite-Samuell Farm facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits ... terms of the latter, setting the bar too high can result in disappointment, perhaps ... slow progress toward their goal. , Research from PsychTests.com reveals that ...
(Date:6/24/2016)... ... 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out of ... verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
(Date:6/23/2016)... , June 23, 2016 Research ... Devices Global Market - Forecast to 2022" report to ... the treatment method for the patients with kidney failure, it ... excess fluid from the patient,s blood and thus the treatment ... potassium and chloride in balance. Increasing number ...
(Date:6/23/2016)... Research and Markets has announced the ... 2016 - Forecast to 2022" report to their offering. ... up to date financial data derived from varied research sources ... with potential impact on the market during the next five ... comprises of sub markets, regional and country level analysis. The ...
Breaking Medicine Technology: