Navigation Links
Scientists to design drug for chronic pain
Date:8/24/2012

Scientists at the University of Liverpool and the Royal Liverpool University Hospital have been awarded 1.4 million to design a new drug for the treatment of chronic pain.

The project funded by the Medical Research Council (MRC), addresses the long-standing and urgent need for effective therapies for chronic pain which affects around 20% of adults in Europe and the US, and more than eight million adult patients in the UK alone. Medication currently available to treat the condition is effective in only around 40% of sufferers and even these patients often struggle to maintain the balance between adequate pain relief and the adverse effects of current therapies.

The research team is examining compounds which target the glycine receptor, one of the principal inhibitory neuronal receptors in the central nervous system and crucial in the sensation of chronic pain. Through medicinal chemistry, computational methods and experimental testing, scientists successfully identified novel compounds which could be used for the treatment of chronic pain without unwanted sedative effects.

Professor Martin Leuwer, from the University's Department of Molecular and Clinical Pharmacology in the School of Translational Medicine, said: "This is an exciting project that expands our drug discovery portfolio into a new therapeutic area with a huge unmet medical need. Our collaborative team of medicinal chemists, molecular modellers and neurobiologists have made significant advances in this area and this funding provides us with the opportunity to drive the project forward towards an entirely new class of drug for the treatment of chronic pain conditions.

"We're aiming to develop molecules that target the glycine receptor, into a drug that can be administered as a tablet. Our project concept has been shown to work but further improvements are required if we are to reach the goal of generating a drug which is safe, effective and orally viable. Our ultimate aim is to allow chronic pain patients to regain a dramatically improved quality of life."

He added: "In view of the huge numbers of patients worldwide whose lives are wrecked by chronic pain, the fact that current treatment options are clearly insufficient and the dramatic toll on economies caused by millions of lost working hours, our causal treatment option has the potential to have a tremendous beneficial impact on individuals and societies."
'/>"/>

Contact: Kate Mizen
kate.mizen@liv.ac.uk
0044-151-794-2247
University of Liverpool
Source:Eurekalert

Related medicine news :

1. Scientists from UCLA, Israels Technion uncover brains code for pronouncing vowels
2. Scientists ID Cancer-Causing Agent in Smokeless Tobacco
3. UCSB scientists examine effects of manufactured nanoparticles on soybean crops
4. Scientists report promising new direction for cognitive rehabilitation in the elderly
5. Scientists to investigate preventing life-threatening complications in transplant patients
6. Scientists decode TREX which could see new treatments for cancer realized
7. Scientists devise new strategy to destroy multiple myeloma
8. Scientists ID New Gene Regions Linked to Type 2 Diabetes
9. Scientists discover how iron levels and a faulty gene cause bowel cancer
10. Scripps Florida scientists awarded nearly $1.5 million to develop new approaches to treat cancer
11. Scientists ID New Gene Linked to Vision Loss in Infants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... ... have been diagnosed with endometriosis. These women need a treatment plan to not ... comprehensive approach that can help for preservation of fertility and ultimately achieving a ...
(Date:6/25/2016)... Miami, FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton ... Plant City Observer , brings up a new, often overlooked aspect of head lice: ... The closing for fumigation is not a common occurrence, but a necessary one in the ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar ... M.D from the David Geffen School of Medicine at UCLA. He trained in Internal ... complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the ... In terms of the latter, setting the bar too high can result in disappointment, ... just slow progress toward their goal. , Research from PsychTests.com reveals ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)...  MedSource announced today that it has selected ... of choice.  This latest decision demonstrates MedSource,s commitment ... clients by offering a state-of-the-art electronic data capture ... as the EDC platform of choice in exchange ... has long been a preferred EDC platform by ...
(Date:6/23/2016)... 2016  In a startling report released today, National Safety ... lacking a comprehensive, proven plan to eliminate prescription opioid overdoses. ... how states are tackling the worst drug crisis in recorded U.S. ... Kentucky , New Mexico , ... Of the 28 failing states, three – Michigan ...
(Date:6/23/2016)... -- Research and Markets has announced the addition ... to their offering. The ... commercial environment for MedImmune to enter. The US ageing population ... to drive considerable growth for effective anti-influenza medications. The introduction ... considerably, but development is still in its infancy. ...
Breaking Medicine Technology: