Navigation Links
Scientists study serious immune malfunction
Date:5/17/2012

Defects in the gene that encodes the XIAP protein result in a serious immune malfunction. Scientists used biochemical analyses to map the protein's ability to activate vital components of the immune system. Their results have recently been published in Molecular Cell, a journal of international scientific repute.

Researchers at The Novo Nordisk Foundation Center for Protein Research at the University of Copenhagen have mapped how the XIAP protein activates a vital component of the immune defence system, specifically the component that fights bacterial infections in the gastro-intestinal system:

"Our results are an important step on the way to understanding the very serious but fortunately rare genetic immune disorder called X-linked lymphoproliferative syndrome type 2 (XLP2), which affects male children," says Associate Professor Mads Gyrd-Hansen from the The Novo Nordisk Foundation Center for Protein Research, and explains more about the disease:

"The gastro-intestinal system can be viewed as a long tube running through the body, absorbing nutrients and water. The contact surface between the intestinal system and the rest of the body is protected by an efficient immune barrier that confines the bacteria to the intestine. This barrier is not intact in XLP2 patients, who thus lack the necessary bulwark, so to say, between bacteria and body."

The new study published in Molecular Cell shows that genetic mutations found in patients with XLP2 specifically destroy XIAP's ability to attach the signalling protein ubiquitin to other proteins. The attachment process is vital for activating the immune system and therefore for survival.

Important knowledge for leukaemia research

While the results from the study published in Molecular Cell are first and foremost relevant for XLP2 patients, cancer researchers can also benefit from the new discoveries:

"Several pharmaceutical companies have developed drugs to act on IAP proteins, including XIAP, as part of cancer treatment. Several of the drugs are currently being tested in clinical trials for their efficacy in treatment of leukaemia and other forms of cancer. It is therefore essential to know precisely which biological processes in the organism the treatment can potentially affect," continues Mads Gyrd-Hansen.

Mads Gyrd-Hansen and his colleagues at The Novo Nordisk Foundation Center for Protein Research have been collaborating for a good 18 months together with research groups in Germany, the UK and Australia, and the competencies of the individual groups have made it possible to rapidly achieve high-quality results quickly:

"International collaboration has made it possible in a short time to describe detailed molecular processes, to use the descriptions to create mouse models for further tests and thereafter to link the results of these tests to genetic mutations identified in patients."


'/>"/>

Contact: Mads Gyrd-Hansen
mads.gyrd@cpr.ku.dk
01-145-518-00089
University of Copenhagen
Source:Eurekalert

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association ... Featuring a collection of specialty vendors and unique items from across the nation, this ... health and wellness services offered by the VNA. The boutique will be open ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... and Agile Software Development, has been awarded a contract by the Center for ... Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in a ...
(Date:10/12/2017)... ... 12, 2017 , ... Planet Fitness, one of the largest and fastest growing ... open a flagship location in Covington, LA at 401 N. U.S. Highway 190, in ... to Office Depot in the Holiday Square shopping center. Its location allows it to ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about ... intend to develop to enable prevention of a major side effect of chemotherapy ... especially in pediatric patients. For cisplatin, hearing loss is FDA listed on-label as ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned ... Michigan’s 2017 Best and Brightest in Wellness® by Best and Brightest. OnSite Wellness ... on Friday, Oct. 20 from 7:30 a.m. to 2 p.m. at the Henry ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... PROVIDENCE, R.I. , Sept. 25, 2017 /PRNewswire/ ... immunogenicity assessment, vaccine design, and immune-engineering today announced ... focused on the development of personalized therapeutic cancer ... and has provided exclusive access to enabling technologies ... MSc Eng., MBA will lead EpiVax Oncology as ...
(Date:9/22/2017)... Sept. 22, 2017  As the latest Obamacare repeal ... Bill Cassidy (R-LA) and Lindsey Graham ... the medical device industry is in an odd place. ... the 2.3% excise tax on medical device sales passed ... want covered patients, increased visits and hospital customers with ...
(Date:9/19/2017)... , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing a ... targeted tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek , ...
Breaking Medicine Technology: