Navigation Links
Scientists study link between amyloid beta peptide levels and Alzheimer's disease
Date:3/20/2012

The effects of the bacterial endotoxin lipopolysaccharide (LPS) has been found to elevate amyloid beta (Aβ) peptide levels in the brain, leading to short-term deficits in learning.

"We have found that after several injections with LPS toxin, (seven consecutive days of LPS administration) mice showed significant elevation in Aβ levels in their brains," said Michael Chumley, assistant professor of biology at Texas Christian University in Fort Worth. "This elevation corresponds with a decreased ability to learn simple tasks."

Scientists have long thought that inflammation might stimulate the onset of Alzheimer's or other cognitive diseases. It is well known that one of the things that cause inflammation in the brain is Aβ plaques, which are produced in response to inflammation. This leads to a self-perpetuating inflammation, where the product of inflammation leads to more inflammation. Scientists continue to research just how these Aβ plaques cause inflammation that leads to diminished brain function.

"What is unique in our study is that we initiated the inflammation in the body of the animal and not in the brain, and it lead to both an elevation of Aβ in the brain and learning deficits," said Chumley. "Our next step will be to determine if it is the Aβ produced in response to the inflammation that is the cause of the short-term memory problems."

"In over 90% of all Alzheimer's disease cases, the so called sporadic AD, the cause is unknown. It is likely that many factors, including genetic, environmental, etc., play a role in the onset of AD. We believe that peripheral inflammation (inflammation outside of the brain and spinal cord), may also be one of these factors," said Chumley.

This research was published in Journal of Behavioural Brain Research in January 2012.


'/>"/>

Contact: Mike Chumley
m.chumley@tcu.edu
817-257-8777
Dick Jones Communications
Source:Eurekalert

Page: 1

Related medicine news :

1. Scientists measure how energy is spent in martial arts
2. Scientists link 2 cancer-promoting pathways in esophageal cancer
3. Hutchinson Center scientists break through pancreas cancer treatment barrier
4. Sanford-Burnham scientists unravel cancer drugs secret to resistance
5. Scientists develop a software tool for estimating heart disease risk
6. UCLA scientists uncover mechanism for melanoma drug resistance
7. No workout? No worries: Scientists prevent muscle loss in mice, despite disease and inactivity
8. New test can better predict successful IVF embryos, scientists say
9. NIH-supported scientists investigate a newly emerging staph strain
10. Scripps Florida scientists uncover inflammatory circuit that triggers breast cancer
11. UCLA scientists report link between traumatic brain injury, post-traumatic stress disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2017)... ... 22, 2017 , ... Silicon Valley startup Enke Life has ... Their electric toothbrushes aggressively attack oral bacteria by reducing dental plaque and other ... edge Enke technology with a premium timeless design, they want to redefine the ...
(Date:9/22/2017)... ... September 22, 2017 , ... Egg ... life. Although frozen embryos have a slight statistical advantage for live births, frozen ... a wonderful opportunity for women undergoing medical treatment or who are concerned about ...
(Date:9/21/2017)... ... September 21, 2017 , ... Process Capability Indices for ... 3:00 p.m. ET, http://www.fdanews.com/processcapabilityindices      , Quality in device ... of The Quality System Regulation (§820.250), and Devicemakers find themselves staring at a ...
(Date:9/21/2017)... ... September 21, 2017 , ... ... of a new member survey conducted by the International Society of Hair ... from 2014 to 2016 rose 60 percent, with 635,189 procedures performed in 2016. ...
(Date:9/21/2017)... ... 21, 2017 , ... Innovatum will demonstrate capabilities of fully ... Conference 2017 in Chicago, IL on October 17-19, 2017. This unique development addresses ... patient safety. , Microscan , a global technology leader in barcoding, ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... , Sept. 6, 2017 Eli Lilly and ... will present new data for galcanezumab and lasmiditan, two ... the International Headache Society (IHC) taking place Sept. 7-10 ... Lilly will highlight new, long-term data from an open-label ... of galcanezumab (120 mg and 240 mg) for the ...
(Date:9/5/2017)... , Sept. 5, 2017 Oramed Pharmaceuticals Inc. ... ), a clinical-stage pharmaceutical company focused on the development ... has successfully concluded its meeting with the U.S. Food ... oral insulin formulation. ... the regulatory pathway for submission of ORMD-0801, would be ...
(Date:8/29/2017)... , Aug. 29, 2017 ivWatch, LLC, the leading provider ... infiltrations, announced it has been awarded an Innovative Technology contract from ... the country. ... device to aid in the early detection of peripheral IV infiltration ... The Innovative Technology contract ...
Breaking Medicine Technology: