Navigation Links
Scientists study link between amyloid beta peptide levels and Alzheimer's disease
Date:3/20/2012

The effects of the bacterial endotoxin lipopolysaccharide (LPS) has been found to elevate amyloid beta (Aβ) peptide levels in the brain, leading to short-term deficits in learning.

"We have found that after several injections with LPS toxin, (seven consecutive days of LPS administration) mice showed significant elevation in Aβ levels in their brains," said Michael Chumley, assistant professor of biology at Texas Christian University in Fort Worth. "This elevation corresponds with a decreased ability to learn simple tasks."

Scientists have long thought that inflammation might stimulate the onset of Alzheimer's or other cognitive diseases. It is well known that one of the things that cause inflammation in the brain is Aβ plaques, which are produced in response to inflammation. This leads to a self-perpetuating inflammation, where the product of inflammation leads to more inflammation. Scientists continue to research just how these Aβ plaques cause inflammation that leads to diminished brain function.

"What is unique in our study is that we initiated the inflammation in the body of the animal and not in the brain, and it lead to both an elevation of Aβ in the brain and learning deficits," said Chumley. "Our next step will be to determine if it is the Aβ produced in response to the inflammation that is the cause of the short-term memory problems."

"In over 90% of all Alzheimer's disease cases, the so called sporadic AD, the cause is unknown. It is likely that many factors, including genetic, environmental, etc., play a role in the onset of AD. We believe that peripheral inflammation (inflammation outside of the brain and spinal cord), may also be one of these factors," said Chumley.

This research was published in Journal of Behavioural Brain Research in January 2012.


'/>"/>

Contact: Mike Chumley
m.chumley@tcu.edu
817-257-8777
Dick Jones Communications
Source:Eurekalert

Page: 1

Related medicine news :

1. Scientists measure how energy is spent in martial arts
2. Scientists link 2 cancer-promoting pathways in esophageal cancer
3. Hutchinson Center scientists break through pancreas cancer treatment barrier
4. Sanford-Burnham scientists unravel cancer drugs secret to resistance
5. Scientists develop a software tool for estimating heart disease risk
6. UCLA scientists uncover mechanism for melanoma drug resistance
7. No workout? No worries: Scientists prevent muscle loss in mice, despite disease and inactivity
8. New test can better predict successful IVF embryos, scientists say
9. NIH-supported scientists investigate a newly emerging staph strain
10. Scripps Florida scientists uncover inflammatory circuit that triggers breast cancer
11. UCLA scientists report link between traumatic brain injury, post-traumatic stress disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2016)... ... , ... After a year and a half of planning the Multiple Pathways of Recovery ... Pathways of Recovery Conference was held May 2 -4, 2016 at the Mystic Marriott ... together to explore the many pathways individuals use to get into and sustain their recovery. ...
(Date:5/27/2016)... ... 2016 , ... Two director-level employees of Horizon Blue Cross Blue Shield of ... 2016 honorees. The award recognizes businesswomen who excel in their fields and who ... the MLTSS (Managed Long-Term Services and Supports) Program at Horizon NJ Health and Theresa ...
(Date:5/27/2016)... NY (PRWEB) , ... May 27, 2016 , ... This ... of a stroke, which we as a society can control and change. , As ... occurs nearly every 40 seconds within the United States. Plus, with an estimated 129,000 ...
(Date:5/27/2016)... ... May 27, 2016 , ... Aimed ... by inspiring human interest stories, courtesy of leaders in the nursing and health ... the industry, from leading advocates and associations—namely Jones & Bartlett Learning. , Jones ...
(Date:5/26/2016)... ... May 26, 2016 , ... Despite last week’s media reports hinting at ... company to wait until March 2017 for an interest rate increase, according to Rajeev ... of Business. , “The Federal Open Market Committee (FOMC) dot charts are of interest ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... CAMBRIDGE, England , May 25, 2016 /PRNewswire/ ... genomics company employing the precision of circulating tumour ... oncology, today announces the appointment of Professor ... will provide medical leadership across the clinical development ... that Inivata,s products help deliver significant improvements in ...
(Date:5/24/2016)... 24, 2016 Cirujanos holandeses han ... a los médicos a compartir sus mejores prácticas por ... mundial. Profesionales médicos de Europa, África, Asia ... a la aplicación, que combina la transmisión en vivo ... seguro. Educación   "Imagine un médico ...
(Date:5/24/2016)... May 24, 2016  Diana Russell suffers from a ... from the inside out.  This disease has put her ... her children and grandchildren to leave her home.  Because ... family cannot haul the wheelchair.  So if there is ... and Diana is left to wait for the bus. ...
Breaking Medicine Technology: