Navigation Links
Scientists strike blow in superbugs struggle
Date:12/5/2007

Scientists from The University of Manchester have pioneered new ways of tweaking the molecular structure of antibiotics an innovation that could be crucial in the fight against powerful super bugs.

The work, led by chemical biologist Dr Jason Micklefield in collaboration with geneticist Professor Colin Smith, is published online today (Wednesday 5 December 2007) and will appear in next issue of the Journal of the American Chemical Society.

Using funding from the UKs Biotechnology and Biological Sciences Research Council (BBSRC), scientists working in The School of Chemistry and the Manchester Interdisciplinary Biocentre have paved the way for the development of new types of antibiotics capable of fighting increasingly resistant bacteria.

Micklefield, Smith and colleagues were the first to engineer the biosynthesis of lipopeptide antibiotics of this class back in 2002.

They have now developed methodologies for altering the structure of these antibiotics, such as mutating, adding and deleting components.

This innovation provides access to thousands of lipopeptide variants that cannot be produced easily in any other way.

Dr Micklefield said: The results from this work are essential in the development of the next generation of lipopeptide antibiotics, which are critical to combat emerging super bugs that have acquired resistance to other antibiotics.

The potent activity of this class of antibiotics against pathogens that are resistant to all current antibiotic treatments makes them one of the most important groups of antibiotics available.

Our work relies on interdisciplinary chemical-biology, spanning chemistry through to molecular genetics. It follows the tradition of pioneering work in natural product biosynthesis and engineering that has come out of the UK.

Scientists in Manchester have been doing work on calcium dependant antibiotics (CDA), which belong to the same family of ac
'/>"/>

Contact: Alex Waddington
alex.waddington@manchester.ac.uk
01-163-063-983
University of Manchester
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... July 11, 2014 As reported by ... For Cocaine: Are Genetics To Blame (6/30), Indino Downey ... cocaine and paraphernalia to smoke it with. His father, ... that his son inherited from him may have something ... made the news during the 1980s and 1990s for ...
(Date:7/11/2014)... Los Angeles, CA (PRWEB) July 11, 2014 ... Kevin Sands today announces that he uses mini and ... these treatments offer the defining feature that distinguishes dental ... of teeth in addition to the crowns. This alone ... dental implants also offer advantages related to comfort, ...
(Date:7/11/2014)... FRIDAY, July 11, 2014 (HealthDay News) -- Polio is ... in places like Afghanistan, Nigeria and Pakistan. Giving vaccinated ... boost their immunity and help eradicate the highly infectious ... vaccine is highly effective, immunity wanes as early as ... still be infected and contribute to the spread of ...
(Date:7/11/2014)... For breast cancer patients, the era of personalized medicine ... advances by USC Stem Cell researcher Min Yu and ... , In a July 11 study in Science ... breast cancer cells circulating through the blood streams of ... the "seeds" of metastasis, which travel to and establish ...
(Date:7/11/2014)... Jupiter, FL (PRWEB) July 11, 2014 ... airing on RFD-TV, next Tuesday, July 15, 2014, at ... explores Sunbelt's line of proprietary products, which are designed ... agricultural crops. Audiences will learn how these products help ... the environment in which it is grown. , The ...
Breaking Medicine News(10 mins):Health News:Roberty Downey's Son Arrested For Cocaine 2Health News:Dental Implant Dentist, Kevin Sands DDS, Now Uses Mini and Full Mouth Implants to Replace Missing Teeth 2Health News:Researchers Assess New Way to Boost Polio Immunity 2Health News:New Episode of American Farmer Featuring Sunbelt, UniSouth Genetics, and Michigan Milk Producers Association Airing on RFD-TV 2
... The upcoming 25th Anniversary EAU Congress in Barcelona from April ... biggest meetings in recent years with around 12,044 participants already ... one of the biggest international urology meetings in the world ... of the most highly attended and, perhaps, the most extensive ...
... ... fueled by latest release of enterprise business performance management solution , ... Natick, MA (PRWEB) April 9, 2010 ... reporting solutions for small to mid-sized companies today announced an extraordinary 51% increase ...
... at 3 linked to behavior changes at age 5, ... children when they,re 3 seems to lead to more ... into account the child,s initial level of aggression. ... to backfire, new research suggests. , "We all ...
... ... super charged positive attitude? Well now many can download JNL,s iPhone application onto one of ... production for the past few month, making sure that her iPhone went above and beyond ... ...
... ... health care than other nations. Low back pain is the number two most common reason ... other spinal issues will now be able to see, touch and thereby better understand common ... Issaquah, ...
... finds that Hispanics live in areas with more ... cancer screening. Published early online in CANCER ... Society, the study indicates that differences in areas, ... Hispanics are less likely to undergo colorectal cancer ...
Cached Medicine News:Health News:Anniversary EAU Congress in Barcelona tops attendance registrations 2Health News:Centage Corporation Reports 51% Growth in Revenue for Q1 over Same Period as Last Year 2Health News:Centage Corporation Reports 51% Growth in Revenue for Q1 over Same Period as Last Year 3Health News:Spanking May Make a Child More Aggressive 2Health News:Spanking May Make a Child More Aggressive 3Health News:International Fitness Bikini Model Turn Bega-Brand Mogul & Celebrity Jennifer Nicole Lee Launches the JNL iPhone App 2Health News:International Fitness Bikini Model Turn Bega-Brand Mogul & Celebrity Jennifer Nicole Lee Launches the JNL iPhone App 3Health News:International Fitness Bikini Model Turn Bega-Brand Mogul & Celebrity Jennifer Nicole Lee Launches the JNL iPhone App 4Health News:Latest Resource From Dynamic Disc Designs Helps Physicians Educate Patients 2Health News:Latest Resource From Dynamic Disc Designs Helps Physicians Educate Patients 3Health News:Hispanics live in areas with limited capacity for colorectal cancer screening 2
(Date:1/15/2014)... Sono-Tek Corporation (OTC BB: SOTK) today announced sales of  ... to sales of $2,202,000 for the prior year period, an ... also shown growth over the preceding quarter,s sales, continuing a ... year. Markets that experienced sales increases over the prior year ...
(Date:1/15/2014)... 2014 As health officials across the Midwest warn against ... in Michigan will offer free diagnostic ... Meijer pharmacists to administer tests and, in some cases, fill ... participating in the study. The Grand ...
(Date:1/15/2014)... , Jan. 15, 2014 Massachusetts General Hospital ... AMGN ) announced today that they have ... validate new therapeutic targets and develop novel therapies ... that affects millions worldwide. The MGH-Broad-Amgen collaboration brings ...
Breaking Medicine Technology:Sono-Tek Announces Third Quarter Results 2Sono-Tek Announces Third Quarter Results 3Sono-Tek Announces Third Quarter Results 4Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4
... is a semi-rigid system intended for ... Slim-LOC is based on the comprehensive, ... market technology. The Slim-LOC system offers ... Reduced width (16 mm), low profile ...
... Osmium is a cervical plate system ... spine. The implant provides for the ... the bone transplant has consolidated. Optimized ... and bicortical fixation. Maximum purchase also ...
... is designed to meet the clinical challenges ... attached locking mechanism and the choice of ... variable angle screws for ease of implantation ... plate system allows the surgeon the versatility ...
... system is the lowest profile plate clinically ... integrated lock mechanism, which is designed to ... appreciate the narrow width, which decreases the ... system also offers easy to use instrumentation ...
Medicine Products: