Navigation Links
Scientists solve structure of gene regulator that plays key role in cancer
Date:2/13/2008

(PHILADELPHIA) Scientists at The Wistar Institute have collaborated on a major advance in understanding a gene regulator that contributes to some of the deadliest cancers in humans. The culmination of 10 years work, their research paves the way for the development of new cancer therapies.

During much of its lifetime, the DNA that resides in each of our cells exists in an inactive form, stored inside densely knotted structures in the cell nucleus. There, the DNA is wound spool-like around proteins called histones, which bind to and restrict the DNAs activity. For a cell to activate a gene, many proteins, called transcription factors, work in concert to separate DNA from the histones. One family of transcription factors are enzymes known as HATs, or histone acetyltransferases, which transfer acetate groups onto the histones.

Wistar scientists, collaborating with researchers at the Johns Hopkins University School of Medicine, have made a major advance in the understanding of the structure and function of a key HAT enzyme called p300/CBP.

Unlike most HATs, which regulate the expression of only a few genes, p300/CBP is involved in the activation of a wide variety of genes. In addition, aberrant p300/CBP activity contributes to pancreatic, colon, and lung cancer among the deadliest cancers in humans as well as gastric and thyroid cancer and some leukemias. In addition to acting as an oncoprotein by promoting tumors, p300/CBP also can suppress tumors.

These unusual properties have made p300/CBP one of the most studied enzymes in the HAT family, and a target for developing new anti-cancer drugs, says Ronen Marmorstein, Ph.D., a professor in the Gene Expression and Regulation Program at Wistar and a senior author and corresponding author on the study. Philip A. Cole at Johns Hopkins is also a senior author and corresponding author.

Its unusual to have a HAT thats so implicated in cancer, and even more unusual to have one
'/>"/>

Contact: Abbey Porter
aporter@wistar.org
215-898-3943
The Wistar Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. VEGF Neutralization Can Damage Brain Vessels, Say Schepens Eye Research Institute Scientists
2. VEGF neutralization can damage brain vessels, say Schepens Eye Research Institute scientists
3. Precious Time - Scientists discover how long heart failure patients can expect to live
4. UCLA stem cell scientists reprogram human skin cells into embryonic stem cells
5. Scientists Reprogram Human Skin Cells Into Embryonic Stem Cells
6. Scientists from Europe, Israel and the US develop robotic rats to aid in rescue missions
7. Childrens Hospital scientists identify possible target for prevention and treatment of pneumonia
8. NIAID scientists identify new cellular receptor for HIV
9. ECNP launches research grant for young scientists
10. Scientists confirm new virus responsible for deaths of transplant recipients in Australia
11. Bonn scientists simulate dinosaur digestion in the lab
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... FL (PRWEB) , ... July 31, 2015 , ... Like ... enlargement techniques have also been advanced, upgraded, made more effective and less intrusive and ... of Loria Medical Penile Enlargement Center. Dr. Loria currently stands as the only ...
(Date:7/31/2015)... ... July 31, 2015 , ... Florida Hospital ... catheter that was developed for targeted delivery of fluids to selected sites in ... at Florida Hospital Tampa with the device that provides direct, local delivery of ...
(Date:7/31/2015)... N.Y. (PRWEB) , ... July 31, 2015 , ... ... is proud to announce that their latest designer handbag line will be named ... become an Internet sensation as the first globally recognized model with Down syndrome, ...
(Date:7/31/2015)... ... July 31, 2015 , ... According to WFLA on July ... heroin use and eventual overdoses. Thricefold deaths have held steady over the last “couple ... the Sarasota heroin epidemic, which was spurred by the crackdown of prescription painkillers. Many ...
(Date:7/31/2015)... ... 31, 2015 , ... New Energy Works Timberframers invites the public to join ... 15th, 2015 from 9am – 12pm. Timber frame raisings are special, celebrating ... community as the culmination of months of effort, planning, fundraising, and dreaming takes shape. ...
Breaking Medicine News(10 mins):Health News:Loria Medical Penile Enlargement Center to Expand, Offering Practice Partnership to Doctors 2Health News:Florida Hospital Tampa Expands Treatment Options for Patients with Pancreatic Cancer Using New Catheter Technology 2Health News:Florida Hospital Tampa Expands Treatment Options for Patients with Pancreatic Cancer Using New Catheter Technology 3Health News:Florida Hospital Tampa Expands Treatment Options for Patients with Pancreatic Cancer Using New Catheter Technology 4Health News:everMaya to Launch Madeline Stuart Handbag Line 2Health News:everMaya to Launch Madeline Stuart Handbag Line 3Health News:Sarasota Sufferers Increased Heroin Overdoses and Deaths 2Health News:Sarasota Sufferers Increased Heroin Overdoses and Deaths 3Health News:Timber Frame Raising: Granary District Stage Amphitheater Timber Frame Hand-Raising by New Energy Works Timberframers 2Health News:Timber Frame Raising: Granary District Stage Amphitheater Timber Frame Hand-Raising by New Energy Works Timberframers 3
... levels raised risk of disease , , MONDAY, July 28 (HealthDay ... shed light on her risk for breast cancer. , ... (BMD) predicts a greater likelihood of developing breast cancer, independent ... model. , The two measurements together might be used in ...
... Healthcare,s annual compensation issue reports healthy pay raises ... for top ... "recession,proof" reputation remains intact as its top executives continue to ... published today., "One sign that any industry is in ...
... , The European Union has launched the ... ) a project with the aim to measure and ... Trials (2001/20/EC) in all areas or clinical research. Apart ... of the different stakeholders: Commercial Sponsors, Non-Commercial Sponsors, Ethics ...
... Talking to them like children brings out more resistance, ... Alzheimer,s patients may often become upset and even act ... to converse with them, a new,study shows. , Researchers ... people with moderate Alzheimer,s found that the residents often ...
... the radio address by President Bush to the Nation:, ... a,vital program that is saving lives across the developing world ... I thank members of,Congress from both sides of the aisle ... I will be honored to sign it into law next,week., ...
... Anthony Shih,M.D., M.P.H., has rejoined IPRO as ... Planning, after a two-year stint at The ... U.S. health system performance,where he directed the ... Efficiency., (Logo: http://www.newscom.com/cgi-bin/prnh/20080725/DC28791LOGO ), ...
Cached Medicine News:Health News:Bone Density Predicts Chances of Breast Cancer 2Health News:Healthcare Executives Well-Rewarded for Their Work 2Health News:Alzheimer's Patients React Poorly to 'Elderspeak' 2Health News:Alzheimer's Patients React Poorly to 'Elderspeak' 3Health News:Radio Address by President Bush to the Nation 2Health News:Radio Address by President Bush to the Nation 3Health News:IPRO Welcomes Back Anthony Shih as Chief Quality Officer, Strategic Planning Lead 2
(Date:7/30/2015)... 2015  Growth of the U.S. nonprescription market is ... prescription users to the OTC market. Due to an ... Rx-to-OTC switch activity over the next five years with ... new brands entering the market into existing categories. ... years (even those with low to moderate likelihood), the ...
(Date:7/30/2015)... OSAKA, Japan , July 30, 2015 /PRNewswire/ ... completion of the study to fulfill the post-marketing ... from the Pan European Multi-Database Bladder Cancer ... multi-database retrospective matched cohort study, conducted in four ... (pioglitazone HCI) with up to 10 years of ...
(Date:7/30/2015)... , July 30, 2015   Sentrian , ... all preventable hospitalization, recently received confirmation from the ... Patient Intelligence (RPI) solution meets the definition of ... to exercise "Enforcement Discretion." The ... to further FDA regulatory requirements at this time" ...
Breaking Medicine Technology:Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 2Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 3Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 2Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 3Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 4Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 5Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 6FDA Clears Way for Commercial Marketing of Sentrian Remote Patient Intelligence Solution 2FDA Clears Way for Commercial Marketing of Sentrian Remote Patient Intelligence Solution 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: