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Scientists solve mystery of polyketide drug formation
Date:4/1/2008

volutionally select polyketides that could be used for arthritis or diabetes treatment, Tsai said. But we can coax the bacteria to do precisely that, if we can control the ring formation in the polyketides.

Prior to this study, it was not known how nature controls the polyketide ring shape, which is essential for antibiotic and anti-cancer properties.

By using molecular cloning and chemical biology techniques, Tsai and her scientific team discovered that the aromatase/cyclase enzyme has a pocket that shapes the polyketide, promoting a unique ring pattern.

Said Tsai: We hope this will lead to the development of new drugs in such areas as cancer therapeutics, obesity treatment and stem cell research.


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Contact: Jennifer Fitzenberger
jfitzen@uci.edu
949-824-3969
University of California - Irvine
Source:Eurekalert

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