Navigation Links
Scientists show 'swamp gas' protects blood vessels from complications of diabetes
Date:8/2/2011

221.10.254.64

GALVESTON, Texas Hydrogen sulfide is a foul-smelling gas with an odor resembling that of rotten eggs. Sometimes called "swamp gas," this toxic substance is generally associated with decaying vegetation, sewers and noxious industrial emissions. And as odd as it may seem it also plays a critical role in protecting blood vessels from the complications of diabetes, according to a new study from the University of Texas Medical Branch at Galveston.

In the last few years, work from several laboratories has shown that hydrogen sulfide is produced by the body in small amounts, and that this gas plays important roles in the circulatory system. In their new paper, published in the online early edition of the Proceedings of the National Academy of Sciences, the UTMB researchers describe experiments with human endothelial cells (cells from the innermost layer of blood vessels) and diabetic rats that demonstrate the importance of hydrogen sulfide levels in determining whether diabetes will lead to blood vessel complications.

Dr. Szabo's team started by exposing endothelial cells to sugar at a concentration that mimicked a level found in the blood vessels of someone with diabetes. "Upon exposure to such high sugar levels, the cells started to produce increasing amounts of highly reactive toxic free radicals, and as a consequence, they began to die," said Dr. Csaba Szabo, a UTMB professor and the paper's lead author. "Low hydrogen sulfide levels accelerated this process, while constant replacement of hydrogen sulfide protected the cells against the toxic effects of high sugar."

The researchers went on to show that diabetic rats have lower levels of hydrogen sulfide in their circulatory systems than other animals. Furthermore, the team showed that treating diabetic rats for a month with hydrogen sulfide improved the function of their blood vessels.

"The loss of endothelial cell function in diabetes is a first step that leads to many complications, such as eye disease, heart disease, kidney disease, foot disease and others," Szabo said. "The observation that hydrogen sulfide can control an early checkpoint in all of these processes may open the door for new therapies."


'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Related medicine news :

1. Scientists receive funding boost to further research into disease mechanisms of Alzheimer’s
2. Scientists ID Gene Linked to Syndrome Behind Elephant Man Disease
3. Scientists developing new therapy for HER2-positive breast cancer
4. UT Southwestern scientists discover new pathway to potential therapies for advanced prostate cancer
5. Scientists Close in on Origins of Psoriasis, Eczema
6. Hebrew U. scientists identify molecular basis for DNA breakage
7. Scientists Spot Possible Target in Ovarian Cancer
8. 7 in 1 blow: Scientists discover DNA regions influencing prostate cancer risk
9. Gold nanoparticles bring scientists closer to a treatment for cancer
10. Scientists identify order of mutations that lead to cancer
11. Scientists discover new molecular pathway involved in wound-healing and temperature sensation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... , ... October 13, 2017 , ... Many families have ... many long-term care insurance companies have a waiver for care if the client has ... period, when the family pays for care, is often waived, so the benefits from ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Ellevate Network, ... in business to advocate for action towards gender equality at their inaugural Summit in ... around the globe, and reached a social audience of over 3 million. To watch ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer ... one of the most popular and least understood books in the Holy Scriptures, Revelation. ... descriptions that have baffled scholars for centuries. Many have tossed it off as mere ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader ... been awarded a contract by the Center for Medicare and Medicaid Services (CMS). ... the enterprise use of Agile methodologies in a consistent and high value manner ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian ... On The Brink” is the creation of published author, William Nowers. Captain Nowers ... a WWII veteran, he spent thirty years in the Navy. Following his career ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... -- Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided an ... Puerto Rico , where the company ... Following a comprehensive onsite assessment, ... damage, temporary loss of power and minimal water damage ... operations have resumed, and the company expects to return ...
(Date:10/10/2017)... --  West Pharmaceutical Services, Inc. (NYSE: WST), a ... today shared the results of a study highlighting the ... administration of polio vaccines. The study results were presented ... by Dr. Ondrej Mach , Clinical Trials and ... and recently published in the journal Vaccine. i ...
(Date:10/5/2017)... 2017  In response to the nationwide opioid ... Surgeons (AAOMS) released prescribing recommendations that urge ibuprofen ... as a first-line therapy to manage a patient,s ... Recognizing the value and importance of ... Prescribing: Acute and Postoperative Pain Management" stresses that ...
Breaking Medicine Technology: