Navigation Links
Scientists show 'swamp gas' protects blood vessels from complications of diabetes
Date:8/2/2011

221.10.254.64

GALVESTON, Texas Hydrogen sulfide is a foul-smelling gas with an odor resembling that of rotten eggs. Sometimes called "swamp gas," this toxic substance is generally associated with decaying vegetation, sewers and noxious industrial emissions. And as odd as it may seem it also plays a critical role in protecting blood vessels from the complications of diabetes, according to a new study from the University of Texas Medical Branch at Galveston.

In the last few years, work from several laboratories has shown that hydrogen sulfide is produced by the body in small amounts, and that this gas plays important roles in the circulatory system. In their new paper, published in the online early edition of the Proceedings of the National Academy of Sciences, the UTMB researchers describe experiments with human endothelial cells (cells from the innermost layer of blood vessels) and diabetic rats that demonstrate the importance of hydrogen sulfide levels in determining whether diabetes will lead to blood vessel complications.

Dr. Szabo's team started by exposing endothelial cells to sugar at a concentration that mimicked a level found in the blood vessels of someone with diabetes. "Upon exposure to such high sugar levels, the cells started to produce increasing amounts of highly reactive toxic free radicals, and as a consequence, they began to die," said Dr. Csaba Szabo, a UTMB professor and the paper's lead author. "Low hydrogen sulfide levels accelerated this process, while constant replacement of hydrogen sulfide protected the cells against the toxic effects of high sugar."

The researchers went on to show that diabetic rats have lower levels of hydrogen sulfide in their circulatory systems than other animals. Furthermore, the team showed that treating diabetic rats for a month with hydrogen sulfide improved the function of their blood vessels.

"The loss of endothelial cell function in diabetes is a first step that leads to many complications, such as eye disease, heart disease, kidney disease, foot disease and others," Szabo said. "The observation that hydrogen sulfide can control an early checkpoint in all of these processes may open the door for new therapies."


'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Related medicine news :

1. Scientists receive funding boost to further research into disease mechanisms of Alzheimer’s
2. Scientists ID Gene Linked to Syndrome Behind Elephant Man Disease
3. Scientists developing new therapy for HER2-positive breast cancer
4. UT Southwestern scientists discover new pathway to potential therapies for advanced prostate cancer
5. Scientists Close in on Origins of Psoriasis, Eczema
6. Hebrew U. scientists identify molecular basis for DNA breakage
7. Scientists Spot Possible Target in Ovarian Cancer
8. 7 in 1 blow: Scientists discover DNA regions influencing prostate cancer risk
9. Gold nanoparticles bring scientists closer to a treatment for cancer
10. Scientists identify order of mutations that lead to cancer
11. Scientists discover new molecular pathway involved in wound-healing and temperature sensation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2016)... ... May 28, 2016 , ... May 26, 2016- In search of the K. ... theme event of “K Warriors” on June 4, 2016 at Ashbury Hotel and Suites ... is sponsored and hosted by Shaolin Institute and sanctioned by KSF (Kungfu Sanda Federation), ...
(Date:5/27/2016)... Columbia, SC (PRWEB) , ... May 27, 2016 , ... ... launched a line of classic American timber frame barn kits, which can be found ... are inspired by historic American barn plans, and they highlight the craftsmanship of ...
(Date:5/27/2016)... ... 2016 , ... With over 60 percent of acute stroke survivors being left ... to aid in the rehabilitation process has steadily increased. Ekso Bionics had been working ... due to stroke. , Ekso Bionics has now received clearance from the U.S. Food ...
(Date:5/27/2016)... Texas (PRWEB) , ... May 27, 2016 , ... ... satisfying Army body fat composition regulations. This is the first time that Coolsculpting ... normally screened at least every six months to ensure they meet the prescribed body-fat ...
(Date:5/27/2016)... ... May 27, 2016 , ... With a team ... and food industries. Aside from its GMP accreditation, Validation Center is also a ... certified products, services and staff. , Validation Center is ISO17025 accredited and only ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... NORTH CHESTERFIELD, Va. , May 25, 2016 ... commercially-available next-generation sequencing test for wounds and infections. ... fungi, ALL parasites, and select viruses. The test ... infected area. David G. ... advanced molecular testing to facilitate wound healing: "We ...
(Date:5/25/2016)... PUNE, India , May 25, 2016 /PRNewswire/ ... Pipeline Review, H1 2016"market research report that provides ... complete with comparative analysis at various stages, therapeutics ... route of administration (RoA) and molecule type, along ... releases. It also reviews key players involved in ...
(Date:5/24/2016)...   , Study met ... bowel cleansing and superiority in , ... of the ascending colon   ... Norgine B.V. today announced new positive data from the phase ... preparation) versus standard 2 litre PEG with ascorbate. The study met ...
Breaking Medicine Technology: