Navigation Links
Scientists show how molecular switch helps pancreatic cancer beat drugs
Date:1/28/2010

Researchers at the Moores Cancer Center at the University of California, San Diego, have found one reason that pancreatic cancer tumors are so difficult to treat with drugs. They have shown how a molecular switch steps up pancreatic cancer cell survival as well as resistance to a standard chemotherapy drug, and have identified alternate routes cancer cells take to avoid the effects of the therapy.

The findings, by a group led by Andrew M. Lowy, MD, professor of surgery and chief of surgical oncology at the UCSD School of Medicine and the Moores UCSD Cancer Center, are reported online and will appear February 1 in the journal Cancer Research. The study provides new insights into pancreatic cancer development and new potential drug targets and treatment strategies against the disease.

"To understand how to treat pancreatic cancer tumors, we need to better understand their circuitry and behavior," Lowy said.

Pancreatic cancer is a particularly deadly cancer, fast-moving and difficult to detect early. It's estimated that more than 35,000 people died from pancreatic cancer last year in the United States.

RON is a signaling protein known as a tyrosine kinase, essentially a switch that turns on various activities in cells. Previous work in Lowy's lab showed that RON is overexpressed in a majority of precancerous and pancreatic cancer cells, and could also help cells resist dying. The researchers wanted to find out what role, if any, RON played in pancreatic cancer development and progression.

In a series of experiments, the researchers showed that RON sends signals that regulate the activity of genes that help tumors cells survive, "implying RON is a potent survival signal for pancreatic cancer cells," Lowy said.

To see the effects of reducing or blocking RON activity, the team shut down RON expression in pancreatic cancer cells using a molecular technique called "gene silencing," and then used those cel
'/>"/>

Contact: Steve Benowitz
sbenowitz@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2015)... ... August 04, 2015 , ... ... and reproductive health and rights in Indonesia for a select group of U.S.-based ... of sites in Indonesia and attend the International Conference on Family Planning in ...
(Date:8/4/2015)... Angeles, California (PRWEB) , ... August 04, 2015 ... ... drawer slides to Los Angeles commercial customers. Finding reliable hardware can be ... unfortunate liabilities. When putting an office together or designing a new facility, ...
(Date:8/4/2015)... (PRWEB) , ... August 04, 2015 , ... ... the industry. , Worldwide Power Products is expanding its reach in Texas. Effective ... the Alpine Power Systems North Texas generator division. With the North Texas ...
(Date:8/4/2015)... ... August 04, 2015 , ... Many men are confused about the safety ... is standing up as a voice of authority for men seeking accurate information about ... with special experience and expertise in the safe and effective treatment of low testosterone. ...
(Date:8/4/2015)... ... August 04, 2015 , ... Increasingly, patients are researching online ... physician. In an effort to share more and better information with these savvy ... publicly share patient satisfaction ratings and comments about its doctors and advanced practice ...
Breaking Medicine News(10 mins):Health News:UN Foundation Announces Press Fellowship to Indonesia with Focus on Women’s Health and Rights 2Health News:Ryadon, Inc. is Now Offering their Ball Bearing Drawer Slides to Los Angeles, CA Commercial Customers 2Health News:Ryadon, Inc. is Now Offering their Ball Bearing Drawer Slides to Los Angeles, CA Commercial Customers 3Health News:Ryadon, Inc. is Now Offering their Ball Bearing Drawer Slides to Los Angeles, CA Commercial Customers 4Health News:North Texas Acquisition Press Release 2Health News:New Video from Renew Man™ Raises Awareness of the Right Way to Correct Low Testosterone 2Health News:New Video from Renew Man™ Raises Awareness of the Right Way to Correct Low Testosterone 3Health News:UPMC 1st in Pa. to Share Provider Ratings 2Health News:UPMC 1st in Pa. to Share Provider Ratings 3
... at Tasks, Memory, Everyday Life, SAN FRANCISCO, Nov. ... and other cognitive abilities of older adults, according to,researchers ... of America, a gathering of 3500 aging experts held ... the University of Southern California Andrus,Gerontology Center in Los ...
... for ... Hill-Rom, BATESVILLE, Ind., ... Hill-Rom subsidiary has,selected Singapore as the site for its Asia-Pacific Innovation Center. ... research,& development (R&D) projects for global applications and will become a,center of ...
... November 19, 2007 A pilot study ... found that narrow band imaging (NBI) colonoscopy used ... identify flat dysplastic lesions. The research appears in ... peer-reviewed scientific journal of the American Society for ...
... St. Louis, Nov. 18, 2007 A multinational team of ... system can stop the growth of a cancerous tumor without ... to use the immune system to eradicate cancers, a technique ... this approach exists: When the cancer can,t be killed with ...
... raised peoples, test scores, researchers say , SUNDAY, Nov. ... boost brainpower, new research suggests. , A U.S. team ... a day improves memory and test scores. , They ... traditional kinds of mental exercise in boosting memory and ...
... growing healthcare ... look under the covers of hospital costs and, efficiencies using more ... ... Nov. 18 A new benchmarking study was,launched today to measure the cost ...
Cached Medicine News:Health News:Brain Exercises Sharpen Memory in Older Adults 2Health News:Brain Exercises Sharpen Memory in Older Adults 3Health News:Hill-Rom Announces Singapore Will Be Site for Asia-Pacific Innovation Center 2Health News:Hill-Rom Announces Singapore Will Be Site for Asia-Pacific Innovation Center 3Health News:Hill-Rom Announces Singapore Will Be Site for Asia-Pacific Innovation Center 4Health News:Hill-Rom Announces Singapore Will Be Site for Asia-Pacific Innovation Center 5Health News:Narrow band imaging colonoscopy identifies flat dysplastic lesions in ulcerative colitis patients 2Health News:Narrow band imaging colonoscopy identifies flat dysplastic lesions in ulcerative colitis patients 3Health News:Immune system can drive cancers into dormant state 2Health News:Immune system can drive cancers into dormant state 3Health News:Immune system can drive cancers into dormant state 4Health News:Talking With Others May Make You Smarter 2Health News:Global Health Support Service Benchmark Study to Combat Growing Healthcare Costs and Prepare for Likely Health Care Reforms 2
(Date:8/4/2015)... Second Quarter 2015 Highlights: , Net Revenue increased to ... Net earnings attributable to Team Health Holdings, Inc. ("Net earnings") ... net earnings per share of $0.39; Adjusted EPS of $0.70 ... 2015 Outlook: , Projected 2015 net revenue ... EBITDA margin remains between 10.5% and 11.0% ...
(Date:8/4/2015)... , Aug. 4, 2015 Among 1,000 U.S. ... yet only half of consumers surveyed are aware of ... ever used use them, according to findings from a ... community service partnership focused on improving the health and ... online survey polled 1,000 men and women, ages 21 ...
(Date:8/4/2015)... Aug. 4, 2015  Ironshore Pharmaceuticals & Development, ... Health, a company specializing in personalized medicine, to ... trial, designed to evaluate the safety and efficacy ... treat Attention-deficit/hyperactivity disorder (ADHD). This is Restore,s second ... Health originally partnered with Ironshore in 2014 and ...
Breaking Medicine Technology:Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 2Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 3Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 4Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 5Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 6Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 7Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 8Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 9Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 10Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 11Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 12Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 13Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 14Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 15Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 16Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 17Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 18Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 19Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 20Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 21Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 22Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 23Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 24Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 25Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 26Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 27Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 28Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 29Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 30Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 31Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 32Team Health Holdings, Inc. Announces Second Quarter 2015 Financial Results 33New Study Finds Consumers are Leaving Money at the Pharmacy 2New Study Finds Consumers are Leaving Money at the Pharmacy 3Restore Health Secures Another Clinical Trial with Ironshore Pharmaceuticals & Development 2
... centration of the flap and provides a spatula ... The corneal marker has a pararadial mark that ... flap after treatment. The spatula may be used ... it back into place following laser treatment. The ...
Flat curved 1 mm spatula blade 30 mm long with marks at 5 mm, 6 mm and 7 mm from tip, polished finish and round knurled handle. Most popular size or model....
6 mm wide by 15 mm long blade with three grooves. 2 mm wide by 31 mm blade with last 7 mm angle tip. Flat serrated handle with polished finish. Most popular size or model....
Short handled spatula for use through the side port stab incision. The malleable silver 0.5 mm tip can be shaped to the surgeon's preference for maximum control. Round serrated handle....
Medicine Products: